Comment on "Deuterium--tritium fusion reactors without external fusion breeding" by Eliezer et al

Inclusion of inverse Compton effects in the calculation of deuterium-deuterium burn under the extreme conditions considered by Eliezer et al. [Phys. Lett. A 243 (1998) 298] are shown to decrease the maximum burn temperature from about 300 keV to only 100--150 keV. This decrease is such that tritium breeding by the DD --> T + p reaction is not sufficient to replace the small amount of tritium that is initially added to the deuterium plasma in order to trigger ignition at less than 10 keV.Comment: 6 pages, 1 tabl

Cornelius Lanczos's derivation of the usual action integral of classical electrodynamics

The usual action integral of classical electrodynamics is derived starting from Lanczos's electrodynamics -- a pure field theory in which charged particles are identified with singularities of the homogeneous Maxwell's equations interpreted as a generalization of the Cauchy-Riemann regularity conditions from complex to biquaternion functions of four complex variables. It is shown that contrary to the usual theory based on the inhomogeneous Maxwell's equations, in which charged particles are identified with the sources, there is no divergence in the self-interaction so that the mass is finite, and that the only approximation made in the derivation are the usual conditions required for the internal consistency of classical electrodynamics. Moreover, it is found that the radius of the boundary surface enclosing a singularity interpreted as an electron is on the same order as that of the hypothetical "bag" confining the quarks in a hadron, so that Lanczos's electrodynamics is engaging the reconsideration of many fundamental concepts related to the nature of elementary particles.Comment: 16 pages. Final version to be published in "Foundations of Physics

Realizations of the Lie superalgebra q(2) and applications

The Lie superalgebra q(2) and its class of irreducible representations V_p of dimension 2p (p being a positive integer) are considered. The action of the q(2) generators on a basis of V_p is given explicitly, and from here two realizations of q(2) are determined. The q(2) generators are realized as differential operators in one variable x, and the basis vectors of V_p as 2-arrays of polynomials in x. Following such realizations, it is observed that the Hamiltonian of certain physical models can be written in terms of the q(2) generators. In particular, the models given here as an example are the sphaleron model, the Moszkowski model and the Jaynes-Cummings model. For each of these, it is shown how the q(2) realization of the Hamiltonian is helpful in determining the spectrum.Comment: LaTeX file, 15 pages. (further references added, minor changes in section 5

Clock-dependent chromatin topology modulates circadian transcription and behavior.

The circadian clock in animals orchestrates widespread oscillatory gene expression programs, which underlie 24-h rhythms in behavior and physiology. Several studies have shown the possible roles of transcription factors and chromatin marks in controlling cyclic gene expression. However, how daily active enhancers modulate rhythmic gene transcription in mammalian tissues is not known. Using circular chromosome conformation capture (4C) combined with sequencing (4C-seq), we discovered oscillatory promoter-enhancer interactions along the 24-h cycle in the mouse liver and kidney. Rhythms in chromatin interactions were abolished in arrhythmic <i>Bmal1</i> knockout mice. Deleting a contacted intronic enhancer element in the <i>Cryptochrome 1</i> ( <i>Cry1</i> ) gene was sufficient to compromise the rhythmic chromatin contacts in tissues. Moreover, the deletion reduced the daily dynamics of <i>Cry1</i> transcriptional burst frequency and, remarkably, shortened the circadian period of locomotor activity rhythms. Our results establish oscillating and clock-controlled promoter-enhancer looping as a regulatory layer underlying circadian transcription and behavior

Maxwell Fields and Shear-Free Null Geodesic Congruences

We study and report on the class of vacuum Maxwell fields in Minkowski space that possess a non-degenerate, diverging, principle null vector field (null eigenvector field of the Maxwell tensor) that is tangent to a shear-free null geodesics congruence. These congruences can be either surface forming (the tangent vectors proportional to gradients) or not, i.e., the twisting congruences. In the non-twisting case, the associated Maxwell fields are precisely the Lienard-Wiechert fields, i.e., those Maxwell fields arising from an electric monopole moving on an arbitrary worldline. The null geodesic congruence is given by the generators of the light-cones with apex on the world-line. The twisting case is much richer, more interesting and far more complicated. In a twisting subcase, where our main interests lie, it can be given the following strange interpretation. If we allow the real Minkowski space to be complexified so that the real Minkowski coordinates x^a take complex values, i.e., x^a => z^a=x^a+iy^a with complex metric g=eta_abdz^adz^b, the real vacuum Maxwell equations can be extended into the complex and rewritten as curlW =iWdot, divW with W =E+iB. This subcase of Maxwell fields can then be extended into the complex so as to have as source, a complex analytic world-line, i.e., to now become complex Lienard-Wiechart fields. When viewed as real fields on the real Minkowski space, z^a=x^a, they possess a real principle null vector that is shear-free but twisting and diverging. The twist is a measure of how far the complex world-line is from the real 'slice'. Most Maxwell fields in this subcase are asymptotically flat with a time-varying set of electric and magnetic moments, all depending on the complex displacements and the complex velocities.Comment: 3

Finding Homogeneity in Heterogeneity—A New Approach to Quantifying Landscape Mosaics Developed for the Lao PDR

A key challenge for land change science in general and research on swidden agriculture in particular, is linking land cover information to human–environment interactions over larger spatial areas. In Lao PDR, a country facing rapid and multi-level land change processes, this hinders informed policy- and decision-making. Crucial information on land use types and people involved is still lacking. This article proposes an alternative approach for the description of landscape mosaics. Instead of analyzing local land use combinations, we studied land cover mosaics at a meso-level of spatial scale and interpreted these in terms of human–environmental interactions. These landscape mosaics were then overlaid with population census data. Results showed that swidden agricultural landscapes, involving 17% of the population, dominate 29% of the country, while permanent agricultural landscapes involve 74% of the population in 29% of the territory. Forests still form an important component of these landscape mosaics

An applied methodology for stakeholder identification in transdisciplinary research

In this paper we present a novel methodology for identifying stakeholders for the purpose of engaging with them in transdisciplinary, sustainability research projects. In transdisciplinary research, it is important to identify a range of stakeholders prior to the problem-focussed stages of research. Early engagement with diverse stakeholders creates space for them to influence the research process, including problem definition, from the start. However, current stakeholder analysis approaches ignore this initial identification process, or position it within the subsequent content-focussed stages of research. Our methodology was designed as part of a research project into a range of soil threats in seventeen case study locations throughout Europe. Our methodology was designed to be systematic across all sites. It is based on a snowball sampling approach that can be implemented by researchers with no prior experience of stakeholder research, and without requiring significant financial or time resources. It therefore fosters transdisciplinarity by empowering physical scientists to identify stakeholders and understand their roles. We describe the design process and outcomes, and consider their applicability to other research projects. Our methodology therefore consists of a two-phase process of design and implementation of an identification questionnaire. By explicitly including a design phase into the process, it is possible to tailor our methodology to other research projects

Difficult tracheal intubation in neonates and infants. NEonate and Children audiT of Anaesthesia pRactice IN Europe (NECTARINE): a prospective European multicentre observational study

Background: Neonates and infants are susceptible to hypoxaemia in the perioperative period. The aim of this study was to analyse interventions related to anaesthesia tracheal intubations in this European cohort and identify their clinical consequences. Methods: We performed a secondary analysis of tracheal intubations of the European multicentre observational trial (NEonate and Children audiT of Anaesthesia pRactice IN Europe [NECTARINE]) in neonates and small infants with difficult tracheal intubation. The primary endpoint was the incidence of difficult intubation and the related complications. The secondary endpoints were the risk factors for severe hypoxaemia attributed to difficult airway management, and 30 and 90 day outcomes. Results: Tracheal intubation was planned in 4683 procedures. Difficult tracheal intubation, defined as two failed attempts of direct laryngoscopy, occurred in 266 children (271 procedures) with an incidence (95% confidence interval [CI]) of 5.8% (95% CI, 5.1e6.5). Bradycardia occurred in 8% of the cases with difficult intubation, whereas a significant decrease in oxygen saturation (SpO2<90% for 60 s) was reported in 40%. No associated risk factors could be identified among comorbidities, surgical, or anaesthesia management. Using propensity scoring to adjust for confounders, difficult anaesthesia tracheal intubation did not lead to an increase in 30 and 90 day morbidity or mortality. Conclusions: The results of the present study demonstrate a high incidence of difficult tracheal intubation in children less than 60 weeks post-conceptual age commonly resulting in severe hypoxaemia. Reassuringly, the morbidity and mortality at 30 and 90 days was not increased by the occurrence of a difficult intubation event. Clinical trial registration: NCT02350348

Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE)

Background: Neonates and infants requiring anaesthesia are at risk of physiological instability and complications, but triggers for peri-anaesthetic interventions and associations with subsequent outcome are unknown. Methods: This prospective, observational study recruited patients up to 60 weeks' postmenstrual age undergoing anaesthesia for surgical or diagnostic procedures from 165 centres in 31 European countries between March 2016 and January 2017. The primary aim was to identify thresholds of pre-determined physiological variables that triggered a medical intervention. The secondary aims were to evaluate morbidities, mortality at 30 and 90 days, or both, and associations with critical events. Results: Infants (n=5609) born at mean (standard deviation [SD]) 36.2 (4.4) weeks postmenstrual age (35.7% preterm) underwent 6542 procedures within 63 (48) days of birth. Critical event(s) requiring intervention occurred in 35.2% of cases, mainly hypotension (>30% decrease in blood pressure) or reduced oxygenation (SpO2 <85%). Postmenstrual age influenced the incidence and thresholds for intervention. Risk of critical events was increased by prior neonatal medical conditions, congenital anomalies, or both (relative risk [RR]=1.16; 95% confidence interval [CI], 1.04–1.28) and in those requiring preoperative intensive support (RR=1.27; 95% CI, 1.15–1.41). Additional complications occurred in 16.3% of patients by 30 days, and overall 90-day mortality was 3.2% (95% CI, 2.7–3.7%). Co-occurrence of intraoperative hypotension, hypoxaemia, and anaemia was associated with increased risk of morbidity (RR=3.56; 95% CI, 1.64–7.71) and mortality (RR=19.80; 95% CI, 5.87–66.7). Conclusions: Variability in physiological thresholds that triggered an intervention, and the impact of poor tissue oxygenation on patient's outcome, highlight the need for more standardised perioperative management guidelines for neonates and infants. Clinical trial registration: NCT02350348