4,113 research outputs found
Low-thrust solar electric propulsion navigation simulation program
An interplanetary low-thrust, solar electric propulsion mission simulation program suitable for navigation studies is presented. The mathematical models for trajectory simulation, error compensation, and tracking motion are described. The languages, input-output procedures, and subroutines are included
Acylsulfonamide safety-catch linker : promise and limitations for solid-phase oligosaccharide synthesis
Safety-catch linkers are useful for solid-phase oligosaccharide synthesis as they are orthogonal to many common protective groups. A new acylsulfonamide safety-catch linker was designed, synthesized and employed during glycosylations using an automated carbohydrate synthesizer. The analysis of the cleavage products revealed shortcomings for oligosaccharide synthesis
Odyssey: a semi-automated pipeline for phasing, imputation, and analysis of genome-wide genetic data
BACKGROUND:
Genome imputation, admixture resolution and genome-wide association analyses are timely and computationally intensive processes with many composite and requisite steps. Analysis time increases further when building and installing the run programs required for these analyses. For scientists that may not be as versed in programing language, but want to perform these operations hands on, there is a lengthy learning curve to utilize the vast number of programs available for these analyses.
RESULTS:
In an effort to streamline the entire process with easy-to-use steps for scientists working with big data, the Odyssey pipeline was developed. Odyssey is a simplified, efficient, semi-automated genome-wide imputation and analysis pipeline, which prepares raw genetic data, performs pre-imputation quality control, phasing, imputation, post-imputation quality control, population stratification analysis, and genome-wide association with statistical data analysis, including result visualization. Odyssey is a pipeline that integrates programs such as PLINK, SHAPEIT, Eagle, IMPUTE, Minimac, and several R packages, to create a seamless, easy-to-use, and modular workflow controlled via a single user-friendly configuration file. Odyssey was built with compatibility in mind, and thus utilizes the Singularity container solution, which can be run on Linux, MacOS, and Windows platforms. It is also easily scalable from a simple desktop to a High-Performance System (HPS).
CONCLUSION:
Odyssey facilitates efficient and fast genome-wide association analysis automation and can go from raw genetic data to genome: phenome association visualization and analyses results in 3-8 h on average, depending on the input data, choice of programs within the pipeline and available computer resources. Odyssey was built to be flexible, portable, compatible, scalable, and easy to setup. Biologists less familiar with programing can now work hands on with their own big data using this easy-to-use pipeline
Optimal control of linear time delay systems
Obtaining optimal control for linear time varying system with time dela
ERTS-1 applications to Minnesota land use mapping
Land use class definitions that can be operationally employed with ERTS-1 imagery are being developed with the cooperation of personnel from several state, regional, and federal agencies with land management responsibilities within the state and the University of Minnesota. Investigations of urban, extractive, forest, and wetlands areas indicate that it is feasible to subdivide each of these classes into several sub-classes with the use of ERTS-1 images from one or more time periods
Six-body Light-Front Tamm-Dancoff approximation and wave functions for the massive Schwinger model
The spectrum of the massive Schwinger model in the strong coupling region is
obtained by using the light-front Tamm-Dancoff (LFTD) approximation up to
including six-body states. We numerically confirm that the two-meson bound
state has a negligibly small six-body component. Emphasis is on the usefulness
of the information about states (wave functions). It is used for identifying
the three-meson bound state among the states below the three-meson threshold.
We also show that the two-meson bound state is well described by the wave
function of the relative motion.Comment: 19 pages, RevTeX, 7 figures are available upon request; Minor errors
have been corrected; Final version to appear in Phys.Rev.
Estimating the Probability of Failure and Associated Risk of the California Bay Delta Levee System
Recent events in New Orleans have shown the magnitude of life loss and property damage that can occur due to the failure of man-made levees. The California Bay Delta and Sacramento levee systems in California pose a similar or greater level of risk to life and property. In order to effectively mitigate the hazard associated with levee failure a systematic evaluation of risk must be carried out. This paper presents preliminary research into the risk associated with the California Bay Delta. A comprehensive list of failure modes for man-made levees is presented. Preliminary empirical data on the temporal frequency of failure and the consequences of failure in the Bay Delta has been compiled. Also presented is the frequency of high water conditions, frequency of strong ground shaking, and a discussion of possible correlation of failure with these loading conditions. Based on preliminary empirical data, the distribution of the risk function is estimated using Monte Carlo simulations. The general objectives of this paper are to present an approach to levee risk analysis for the California Bay Delta, stimulate discussion, outline the data gaps that exist, and push for continued research on mitigating this hazard
Simulation of 3D Porous Media Flows with Application to Polymer Electrolyte Fuel Cells
A 3D lattice Boltzmann (LB) model with twenty-seven discrete velocities is presented and used for the simulation of three-dimensional porous media flows. Its accuracy in combination with the half-way bounce back boundary condition is assessed. Characteristic properties of the gas diffusion layers that are used in polymer electrolyte fuel cells can be determined with this model. Simulation in samples that have been obtained via X-ray tomographic microscopy, allows to estimate the values of permeability and relative effective diffusivity. Furthermore, the computational LB results are compared with the results of other numerical tools, as well as with experimental value
Renormal-order improvement of the Schwinger mass
The massive Schwinger model may be analysed by a perturbation expansion in
the fermion mass. However, the results of this mass perturbation theory are
sensible only for sufficiently small fermion mass. By performing a
renormal-ordering, we arrive at a chiral perturbation expansion where the
expansion parameter remains small even for large fermion mass. We use this
renormal-ordered chiral perturbation theory for a computation of the Schwinger
mass and compare our results with lattice computations.Comment: Latex file, 13 pages, 3 figures, needed macro: psbox.te
Calculation of production and decay of radioisotopes for future irradiation experiments and ion beam facilities
Abstract.: The design of future radioactive ion beam (RIB) facilites requires the forecast of radio isotope inventory after irradiation. At CERN - ISOLDE, we developed a software that estimates the activity of irradiated materials as a function of time dedicated to radioactive waste management. This tool can also be used for licensing procedures, planning of irradiation experiments and the estimation of yield
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