819 research outputs found

    The crystal structures of some coordination compounds of beryllium and indium

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    PIN5 Patient and Clinician Perceived Benefit of Early Consumption of Famciclovir for the Treatment of Herpes Outbreaks

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    Personality, density and habitat drive the dispersal of invasive crayfish

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    There is increasing evidence that personality traits may drive dispersal patterns of animals, including invasive species. We investigated, using the widespread signal crayfish Pacifastacus leniusculus as a model invasive species, whether effects of personality traits on dispersal were independent of, or affected by, other factors including population density, habitat, crayfish size, sex and limb loss, along an invasion gradient. Behavioural traits (boldness, activity, exploration, willingness to climb) of 310 individually marked signal crayfish were measured at fully-established, newly-established and invasion front sites of two upland streams. After a period at liberty, recaptured crayfish were reassessed for behavioural traits (newly-established, invasion front). Dispersal distance and direction of crayfish movement, local population density, fine-scale habitat characteristics and crayfish size, sex and limb loss were also measured. Individual crayfish exhibited consistency in behavioural traits over time which formed a behavioural syndrome. Dispersal was both positively and negatively affected by personality traits, positively by local population density and negatively by refuge availability. No effect of size, sex and limb loss was recorded. Personality played a role in promoting dispersal but population density and local habitat complexity were also important determinants. Predicting biological invasion in animals is likely to require better integration of these processes

    PRS53 Further Developments of the Asthma Life Impact Scale (ALIS)

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    Portuguese validation of the Cambridge pulmonary hypertension outcome review (CAMPHOR) questionnaire

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    BACKGROUND: Patients with pulmonary arterial hypertension (PAH) and other forms of precapillary pulmonary hypertension (PH) have impaired quality of life (QoL). The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) is a PH-specific patient-reported outcome measure that assesses symptoms, activity limitations and QoL. It was originally developed in UK-English. The main objective of this study was to create an adaptation of the CAMPHOR suitable for a Portuguese-speaking population. METHODS: A multi-step approach was followed: bilingual and lay panel translation; cognitive debriefing interviews; and psychometric testing in repeated postal surveys (2 weeks apart) including assessment of internal consistency, reproducibility and validity. The Nottingham Health Profile (NHP) questionnaire was used as a comparator instrument to test convergent validity. RESULTS: The CAMPHOR was translated without difficulty by the two panels. Cognitive debriefing interviews showed the questionnaire was easily understood and considered relevant to patients' experience with their illness. Psychometric evaluation was performed with 50 PAH patients (47 ± 14 years, 37 women). Cronbach's alpha coefficients showed good internal consistency for the three CAMPHOR scales [Symptoms = 0.95; Activities = 0.93 and QoL = 0.94]. Test-retest coefficients showed that all scales had excellent reliability (Symptoms = 0.94; Activities = 0.89 and QoL = 0.93), indicating low levels of random measurement error. The CAMPHOR correlated as expected with the NHP. The magnitude of correlations followed a similar pattern to those in the original development study. The CAMPHOR also exhibited evidence of known group validity in its ability to distinguish between self-reported severity and general health groups. CONCLUSIONS: A valid and reliable version of the CAMPHOR questionnaire for the European Portuguese-speaking population was developed and is recommended for use.info:eu-repo/semantics/publishedVersio

    Two-Camera Acquisition and Tracking of a Flying Target

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    A method and apparatus have been developed to solve the problem of automated acquisition and tracking, from a location on the ground, of a luminous moving target in the sky. The method involves the use of two electronic cameras: (1) a stationary camera having a wide field of view, positioned and oriented to image the entire sky; and (2) a camera that has a much narrower field of view (a few degrees wide) and is mounted on a two-axis gimbal. The wide-field-of-view stationary camera is used to initially identify the target against the background sky. So that the approximate position of the target can be determined, pixel locations on the image-detector plane in the stationary camera are calibrated with respect to azimuth and elevation. The approximate target position is used to initially aim the gimballed narrow-field-of-view camera in the approximate direction of the target. Next, the narrow-field-of view camera locks onto the target image, and thereafter the gimbals are actuated as needed to maintain lock and thereby track the target with precision greater than that attainable by use of the stationary camera

    Differential transport and local translation of cytoskeletal, injury-response, and neurodegeneration protein mRNAs in axons

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    Recent studies have begun to focus on the signals that regulate axonal protein synthesis and the functional significance of localized protein synthesis. However, identification of proteins that are synthesized in mammalian axons has been mainly based on predictions. Here,weusedaxonspurifiedfromculturesofinjury-conditionedadultdorsalrootganglion(DRG)neuronsandproteomicsmethodology to identify axonally synthesized proteins. Reverse transcription (RT)-PCR from axonal preparations was used to confirm that the mRNA for each identified protein extended into the DRG axons. Proteins and the encoding mRNAs for the cytoskeletal proteins �-actin, peripherin, vimentin, �-tropomyosin 3, and cofilin 1 were present in the axonal preparations. In addition to the cytoskeletal elements, several heat shock proteins (HSP27, HSP60, HSP70, grp75, �B crystallin), resident endoplasmic reticulum (ER) proteins (calreticulin, grp78/BiP, ERp29), proteins associated with neurodegenerative diseases (ubiquitin C-terminal hydrolase L1, rat ortholog of human DJ-1/Park7, �-synuclein, superoxide dismutase 1), anti-oxidant proteins (peroxiredoxins 1 and 6), and metabolic proteins (e.g., phosphoglycerate kinase 1 (PGK 1), � enolase, aldolase C/Zebrin II) were included among the axonally synthesized proteins. Detection of the mRNAs encoding each of the axonally synthesized proteins identified by mass spectrometry in the axonal compartment indicates that th

    Seismogenic deformation field in the Mojave block and implications for tectonics of the eastern California shear zone

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    From the aftershocks of the 1992 Landers earthquake, we infer the orientation of the principal strain rate axes (d_1 > d_2 > d_3; d_1 lengthening), their relative magnitude, and the relative spin of fault blocks by using a micropolar continuum model to invert the seismic P and T axes. The seismogenic deformation is consistent with the geodetic measurements of the coseismic displacement and with the secular deformation of the central Mojave block. Regionally, the aftershock data define two major domains within the central Mojave block: (1) the western Mojave block, including the San Bernardino Mountains and the epicentral area of the Big Bear earthquake, which is characterized by E-W d_1 (lengthening) and N-S d_3 (shortening); and (2) the central Mojave block, including the Landers surface rupture zone, which is characterized by NW-SE d_1 and NE-SW d_3. Inversion for the principal strain axes of geodetically measured coseismic displacements across the Big Bear and Landers seismogenic zones gives results similar to the aftershock inversions for those areas, indicating that the aftershocks accommodate a deformation similar to the main rupture and do not reflect elastic rebound or residual stresses. The background seismicity for 1981 to 1991 shows the same characteristic d_1 and d_3 orientations for the two domains, indicating that the secular seismogenic strain has the same regional geometry as the 1992 coseismic deformation. The micropolar inversion also provides values of the relative vorticity parameter W, which reflects a difference between the vorticity of a shearing continuum and the vorticity of fault-bounded blocks rotating within tabular seismogenic shear zones. The observed fault geometry along the Kickapoo fault suggests a pinned-block model for the local block rotation that is consistent with the values of W obtained from our inversions. We interpret the regional NW-SE orientation of d_1 in the central Mojave block to be characteristic of the dextral eastern California shear zone, which transfers approximately 22% of the Pacific-North American plate motion from the San Andreas system to the Walker Lane Belt in eastern California. Our results and geodetic determinations of the secular shear strain in the central Mojave block indicate that the locus of NW dextral shear generally lies between the San Bernardino Mountains and the Pisgah fault

    Koinonia

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    College Student IssuesCampus Suicide: Lessons Learned, Caryn Grimstead, Bob Neideck, Ann Snow, and Skip Trudeau Conference SpotlightOne Church Many Tribes: Following Jesus the Way God Made You, Richard Twiss Pursuing the Pearl, Ken Fong Residence Life & BeyondBuilding Inclusive Communities in the Residence Hall, Stephen J. Pasiciel Faculty Involvement in Student Development: Teaching Does Not End in the Classroom, Neil Friesland FeaturesThe President\u27s Corner Editor\u27s Disk ACSD Ballot NEW COLUMN: Thinking Theologically, Todd Ream My Senior Year; A Reflection on the First Four Years, Adela Huffordhttps://pillars.taylor.edu/acsd_koinonia/1020/thumbnail.jp
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