Effect of flux-dependent Friedel oscillations upon the effective transmission of an interacting nano-system

We consider a nano-system connected to measurement probes via non interacting leads. When the electrons interact inside the nano-system, the coefficient |ts(E_F)|^2 describing its effective transmission at the Fermi energy E_F ceases to be local. This effect of electron-electron interactions upon |ts(E_F)|^2 is studied using a one dimensional model of spinless fermions and the Hartree-Fock approximation. The non locality of |ts(E_F)|^2 is due to the coupling between the Hartree and Fock corrections inside the nano-system and the scatterers outside the nano-system via long range Friedel oscillations. Using this phenomenon, one can vary |ts(E_F)|^2 by an Aharonov-Bohm flux threading a ring which is attached to one lead at a distance Lc from the nano-system. For small distances Lc, the variation of the quantum conductance induced by this non local effect can exceed 0.1 (e^2/h)

Peso Acceptance Patterns in El Paso

This paper examines the acceptance of peso payments, or currency substitution reverse dollarization, by U.S retail firms near the international border with Mexico. Survey data are drawn from a stratified random sample of 586 retailers located in El Paso, Texas, situated across the border from Ciudad Juarez, Chihuahua, Mexico. Approximately 13 percent of the participant firms accept Mexican pesos in exchange for goods and services. Empirical results indicate that factors such as a firm’s percentage of Spanish speaking employees and distance to the nearest international bridge significantly influence the decision to accept or reject Mexican pesos.Currency Substitution; Mexican Peso; Border Economics; Probit Models

Metal contaminants promote degradation of lipid/DNA complexes during lyophilization

AbstractOxidation reactions represent an important degradation pathway of nucleic acid-based pharmaceuticals. To evaluate the role of metal contamination and chelating agents in the formation of reactive oxygen species (ROS) during lyophilization, ROS generation and the stability of lipid/DNA complexes were investigated. Trehalose-containing formulations were lyophilized with different levels of transition metals. ROS generation was examined by adding proxyl fluorescamine to the formulations prior to freeze-drying. Results show that ROS were generated during lyophilization, and both supercoil content and transfection rates decreased as the levels of metal-induced ROS increased. The experiments incorporating chelators demonstrated that some of these agents (e.g., DTPA, desferal) clearly suppress ROS generation, while others (e.g., EDTA) enhance ROS. Surprisingly, there was not a strong correlation of ROS generated in the presence of chelators with the maintenance of supercoil content. In this study, we demonstrated the adverse effects of the presence of metals (especially Fe2+) in nonviral vector formulations. While some chelators attenuate ROS generation and preserve DNA integrity, the effects of these additives on vector stability during lyophilization are difficult to predict. Further study is needed to develop potent formulation strategies that inhibit ROS generation and DNA degradation during lyophilization and storage

The Economics of Regulations on Hen Housing in California

Beginning January 1, 2015, conventional cage housing for egg-laying hens is scheduled to be prohibited in California. We consider the economic implications of the new hen housing regulations on the California shell egg industry. Our data show that egg production is more costly using noncage systems than conventional cages. The main result of the new regulations will be a drastic reduction in the number of eggs produced in California, a large increase in egg shipments from out of state, little if any change in hen housing for eggs consumed in California, and little change in egg prices in California.animal welfare regulation, hen housing, egg supply, egg prices, egg costs of production, Agribusiness, Agricultural and Food Policy, Agricultural Finance, Consumer/Household Economics, Farm Management, Livestock Production/Industries, Production Economics, Productivity Analysis, Q11, Q18,

LTP Requires a Unique Postsynaptic SNARE Fusion Machinery

SummaryMembrane fusion during exocytosis is mediated by assemblies of SNARE (soluble NSF-attachment protein receptor) and SM (Sec1/Munc18-like) proteins. The SNARE/SM proteins involved in vesicle fusion during neurotransmitter release are well understood, whereas little is known about the protein machinery that mediates activity-dependent AMPA receptor (AMPAR) exocytosis during long-term potentiation (LTP). Using direct measurements of LTP in acute hippocampal slices and an in vitro LTP model of stimulated AMPAR exocytosis, we demonstrate that the Q-SNARE proteins syntaxin-3 and SNAP-47 are required for regulated AMPAR exocytosis during LTP but not for constitutive basal AMPAR exocytosis. In contrast, the R-SNARE protein synaptobrevin-2/VAMP2 contributes to both regulated and constitutive AMPAR exocytosis. Both the central complexin-binding and the N-terminal Munc18-binding sites of syntaxin-3 are essential for its postsynaptic role in LTP. Thus, postsynaptic exocytosis of AMPARs during LTP is mediated by a unique fusion machinery that is distinct from that used during presynaptic neurotransmitter release