The Effects of Hormonal Therapy and Exercise on Bone Turnover in Postmenopausal Women: A Randomised Double-Blind Pilot Study

Abstract Introduction: Hormone replacement therapy (HRT) and walking were investigated independently and in combination, to determine which treatment provided most effect on bone turnover in postmenopausal women. Methods: Using a randomised double-blind pilot study, 10 subjects received HRT (transdermal estradiol, 50 μg/day and oral MPA 5 mg/day) and 12 received placebo for 20 weeks. Following a baseline period of treatment, both groups undertook a graduated walking regimen, which increased in intensity, duration and frequency parameters from weeks 8–20. Measurements of aerobic capacity, female sex hormones, bone formation markers [osteocalcin (OC) and bone alkaline phosphatase (BAP)] and bone resorption markers [deoxypyridinoline (DPD) and pyridinoline (PYR)] were measured at baseline (T1), week 8 (T2) and week 20 (T3). Results: Age, time of postmenopause, weight or body mass index were no different between each groups. The HRT group had significantly higher estradiol levels compared with the placebo group at T2 and T3. FSH and LH levels were significantly reduced following HRT. DPD and PYR were significantly reduced from baseline levels at T2 and T3 with HRT. No significant changes occurred in OC or BAP levels with either HRT or walking. Walking did not change bone turnover markers in either the HRT or placebo group. Conclusion: HRT reduces bone resorption, however, walking alone at the intensity and duration prescribed, or the combination of HRT and walking, provided no additional benefit after menopause. Therefore, HRT, but not walking is an effective treatment in reducing bone turnover in postmenopause women.</jats:p

Hrvatska liturgijska pjesmarica: Pjevajte Gospodu pjesmu novu (III. popravljeno i dopunjeno izdanje)

Bananas have enormous health benefits as a food for both animals and humans. They have been used as a complimentary medicine to treat pathological conditions since ancient times. Recently, there has been increased interest in the scientific validity of the beneficial effects of bananas in alleviating and treating disease conditions including, ulcers, infections, diabetes, diarrhea, colitis and blood pressure. Herein, we write on the potential therapeutic and functional benefits of certain species of bananas when consumed green as well as considering the properties of extracts from the non-fruit parts of the plant. We conclude that green bananas appear to deliver an array of health and therapeutic benefit

Glucagon Receptor Signaling and Glucagon Resistance

Hundred years after the discovery of glucagon, its biology remains enigmatic. Accurate measurement of glucagon has been essential for uncovering its pathological hypersecretion that underlies various metabolic diseases including not only diabetes and liver diseases but also cancers (glucagonomas). The suggested key role of glucagon in the development of diabetes has been termed the bihormonal hypothesis. However, studying tissue-specific knockout of the glucagon receptor has revealed that the physiological role of glucagon may extend beyond blood-glucose regulation. Decades ago, animal and human studies reported an important role of glucagon in amino acid metabolism through ureagenesis. Using modern technologies such as metabolomic profiling, knowledge about the effects of glucagon on amino acid metabolism has been expanded and the mechanisms involved further delineated. Glucagon receptor antagonists have indirectly put focus on glucagon&rsquo;s potential role in lipid metabolism, as individuals treated with these antagonists showed dyslipidemia and increased hepatic fat. One emerging field in glucagon biology now seems to include the concept of hepatic glucagon resistance. Here, we discuss the roles of glucagon in glucose homeostasis, amino acid metabolism, and lipid metabolism and present speculations on the molecular pathways causing and associating with postulated hepatic glucagon resistance

Urinary copper, biochemical marker for diagnostics and biomonitoring of patients with Wilson's disease

Introduction: Wilson's disease is an autosomal recessive trait in which copper metabolism is impaired due to its deposition in several organs of the central nervous system, liver, kidneys and cornea (greenish-brown ring pigment or Kayser-Fleischer ring). The cause of the disease is a mutation in the ATP7B gene, located on chromosome 13, which is responsible for the enzyme synthesis that ensures the transfer of copper from the liver to other organs in the body. Abstract objectives: The main objective of the abstract is to monitor the content of copper in 24h urine in patients with Wilson's disease, who are already registered and are treated at the Clinical Center "Mother Teresa" in Skopje. Material and methods: This is a retrospective study that includes diagnosed and treated patients with Wilson's disease in the period from 2020 to 2021 year. The laboratory examination of the copper content in 24 hour urine was performed at the PHI University Institute of Clinical Biochemistry in Skopje, at the Clinical Center "Mother Teresa" using atomic absorption with a PinAAcle 900F spectrometer. Results: Laboratory tests results of patients with Wilson's disease indicate low serum concentration of both copper and ceruloplasmin and increased copper content >100μg in 24h urine. Conclusion: Biochemical tests and early laboratory diagnostics for copper content in 24h urine is significantly important for monitoring and further treatment of patients with Wilson's disease, especially for preventing life-threatening situations and prolonging the life of this group of patients

Some results of a radon survey in 207 Serbian schools

In this paper the results of radon concentration measurements performed in 207 schools in 7 communities of Southern Serbia are presented. The annual radon concentration varied from 17 Bqm-3 to 428 Bq m-3 with a median value of 96 Bq m-3. The arithmetic mean (AM) of the 207 annual averages was 118 Bq m-3 with a standard deviation (SD) of 78 Bq m-3. The best distribution fitting of radon concentration by log-normal function was obtained. The log-normal parameters are the following: geometric mean (GM) = Bq m-3, geometric standard deviation (GSD) = 1.9. In addition, a spatial distribution of the indoor radon concentration over the investigated areas is observed.JRC.E.8-Nuclear securit

EFFECTIVE DOSE FOR REAL POPULATION EXPOSED TO INDOOR RADON IN DWELLINGS OF THE FORMER URANIUM MINE AREA KALNA (EASTERN SERBIA)

This paper deals with calculated effective doses that members of real population received from radon gas and its short lived progeny during air inhalation in their dwellings at field site Kalna in Eastern Serbia. There are two crucial parameters in effective dose calculation: Dose Conversion Factor (DCF) for particular subjects (including real gender, age and physical activity level) and indoor concentration of radon and its short lived progeny in field area. According to the results of indoor radon measurements in the area of former uranium mine, Kalna, the effective dose for this real population was estimated by using the dosimetric lung model, developed by authors according ICRP Publication 66. Authentic software was developed for determination of effective dose per unit inhaled activity of radon progeny, DCF expressed in unit [mSv/WLM]. The results, obtained according to ICRP 66 dosimeter lung model, were compared with results calculated according to ICRP Publication 65. The dosimetric results were, also, compared and discussed with epidemiological approach data, according to UNSCEAR

Relationship between Type-D personality, physical activity behaviour and climacteric symptoms.

A number of factors have been identified which might influence the variation observed in climacteric symptoms in peri- and post-menopausal women. We examined the role of the distressed or Type-D personality and mode of physical activity or exercise on the climacteric symptoms experienced by peri- or post-menopausal women

SCMR expert consensus statement for cardiovascular magnetic resonance of patients with a cardiac implantable electronic device

Cardiovascular magnetic resonance (CMR) is a proven imaging modality for informing diagnosis and prognosis, guiding therapeutic decisions, and risk stratifying surgical intervention. Patients with a cardiac implantable electronic device (CIED) would be expected to derive particular benefit from CMR given high prevalence of cardiomyopathy and arrhythmia. While several guidelines have been published over the last 16 years, it is important to recognize that both the CIED and CMR technologies, as well as our knowledge in MR safety, have evolved rapidly during that period. Given increasing utilization of CIED over the past decades, there is an unmet need to establish a consensus statement that integrates latest evidence concerning MR safety and CIED and CMR technologies. While experienced centers currently perform CMR in CIED patients, broad availability of CMR in this population is lacking, partially due to limited availability of resources for programming devices and appropriate monitoring, but also related to knowledge gaps regarding the risk-benefit ratio of CMR in this growing population. To address the knowledge gaps, this SCMR Expert Consensus Statement integrates consensus guidelines, primary data, and opinions from experts across disparate fields towards the shared goal of informing evidenced-based decision-making regarding the risk-benefit ratio of CMR for patients with CIEDs