“Mad as Hell”: The Corruption of Personal Humanity in Network through Satire

A film has the power to connect to its viewers through dark or absurd humor, revealing truths we may not want to face. My paper explores how Network shows the corruption of different types of people through satire

"Nested and Overlapping Regimes in the Transatlantic Banana Trade Dispute"

The decade long trans-Atlantic banana dispute was not a traditional trade conflict stemming from antagonistic producers’ interests. Instead, this article argues that the banana dispute is one of the most complex illustrations of the legal and political difficulties created by the nesting and overlapping of international institutions and commitments. The contested Europe-wide banana policy was an artifact of nesting--the fruit of efforts to reconcile the single market with Lomé obligations which then ran afoul of WTO rules. Using counter-factual analysis, this article explores how the nesting of international commitments contributed to creating the dispute, provided forum shopping opportunities which themselves complicated the options of decisionmakers, and hindered resolution of what would otherwise be a pretty straightforward trade dispute. We then draw out implications from this case for the EU, an institution increasingly nested within multilateral mechanisms, and for the issue of the nesting of international institutions in general

Sedimentological constraints on the late Silurian history of the Highland Boundary Fault, Scotland : Implications for Midland Valley Basin development

Peer reviewedPostprin

G protein-coupled receptor signalling in astrocytes in health and disease: A focus on metabotropic glutamate receptors

Work published over the past 10–15 years has caused the neuroscience community to engage in a process of constant re-evaluation of the roles of glial cells in the mammalian central nervous system. Recent emerging evidence suggests that, in addition to carrying out various homeostatic functions within the CNS, astrocytes can also engage in a two-way dialogue with neurons. Astrocytes possess many of the receptors, and some of the ion channels, present in neurons endowing them with an ability to sense and respond to an array of neuronal signals. In addition, an expanding number of small molecules and proteins have been shown to be released by astrocytes in both health and disease. In this commentary we will highlight advances in our understanding of G protein-coupled receptor signalling in astrocytes, with a particular emphasis on metabotropic glutamate (mGlu) receptors. Discussion will focus on the major mGlu receptors expressed in astrocytes, mGlu3 and mGlu5, how these receptors can influence different aspects of astrocyte physiology, and how signalling by these G protein-coupled receptors might change under pathophysiological circumstances

Bayesian Analysis of ODE's: solver optimal accuracy and Bayes factors

In most relevant cases in the Bayesian analysis of ODE inverse problems, a numerical solver needs to be used. Therefore, we cannot work with the exact theoretical posterior distribution but only with an approximate posterior deriving from the error in the numerical solver. To compare a numerical and the theoretical posterior distributions we propose to use Bayes Factors (BF), considering both of them as models for the data at hand. We prove that the theoretical vs a numerical posterior BF tends to 1, in the same order (of the step size used) as the numerical forward map solver does. For higher order solvers (eg. Runge-Kutta) the Bayes Factor is already nearly 1 for step sizes that would take far less computational effort. Considerable CPU time may be saved by using coarser solvers that nevertheless produce practically error free posteriors. Two examples are presented where nearly 90% CPU time is saved while all inference results are identical to using a solver with a much finer time step.Comment: 28 pages, 6 figure

A study of nano-particle based silane consolidants for Globigerina limestone

This STEPS funded study focuses on the application of hybrid and nanoparticle loaded hybrid silane consolidants for the treatment of 'Franka' type Globigerina Limestone. Consolidants act by gluing the deteriorated stone material to the underlying healthy stone (Dukes, 1972; Gutt, 1973; Alessandrini et al., 1975; Garrod, 2001). The consolidants evaluated in this work were a laboratory prepared hybrid silane based on a mixture of tetraethylorthosilicate (TEOS) and 3-(glycidoxypropyl) trimethoxysilane (GPTMS), the same hybrid consolidant loaded with silica nanoparticles and GPTMS-modified silica nanoparticles. In addition, a consolidant based on the hydrolysis product of TEOS was also tested. Prepared consolidants were applied to Globigerina Limestone test blocks by complete immersion. Untreated stone block were used as benchmarks. Following application of the consolidants, half of the treated limestone blocks were subjected to accelerated weathering. Non-weathered and weathered limestone blocks were then characterised by optical and electron microscopy and the stone colour before and after treatment with consolidants was assessed by a colorimetric technique. The pore size distribution before and after application of the different consolidant treatments was assessed by Mercury Intrusion Porosimetry. A water absorption by capillarity technique was also carried out to assess how the water uptake rate into the limestone alters with the different treatments. The mechanical properties of the consolidated limestone blocks were assessed by resistance to sodium sulfate crystallisation. Microscopy observations showed that the consolidants penetrated the stone to different extents depending on the consolidant and the method of application. The hybrid consolidant on its own led to yellowing of the limestone but the addition of nanoparticles to the hybrid (modified or not) appeared to help restore the original colour of the stone. The porosity of the limestone was only marginally affected by the different treatments but the somewhat hydrophobic nature of the consolidants led to a disruption in the capillary flow of water into the limestone.peer-reviewe

Attentional capture by entirely irrelevant distractors

Studies of attentional capture often question whether an irrelevant distractor will capture attention or be successfully ignored (e.g., Folk & Remington, 1998). Here we establish a new measure of attentional capture by distractors that are entirely irrelevant to the task in terms of visual appearance, meaning, and location (colourful cartoon figures presented in the periphery while subjects perform a central letter-search task). The presence of such a distractor significantly increased search RTs, suggesting it captured attention despite its task-irrelevance. Such attentional capture was found regardless of whether the search target was a singleton or not, and for both frequent and infrequent distractors, as well as for meaningful and meaningless distractor stimuli, although the cost was greater for infrequent and meaningful distractors. These results establish stimulus-driven capture by entirely irrelevant distractors and thus provide a demonstration of attentional capture that is more akin to distraction by irrelevant stimuli in daily life

Where do uncertainties reside within environmental risk assessments? Expert opinion on uncertainty distributions for pesticide risks to surface water organisms

A reliable characterisation of uncertainties can aid uncertainty identification during environmental risk assessments (ERAs). However, typologies can be implemented inconsistently, causing uncertainties to go unidentified. We present an approach based on nine structured elicitations, in which subject-matter experts, for pesticide risks to surface water organisms, validate and assess three dimensions of uncertainty: its level (the severity of uncertainty, ranging from determinism to ignorance); nature (whether the uncertainty is epistemic or aleatory); and location (the data source or area in which the uncertainty arises). Risk characterisation contains the highest median levels of uncertainty, associated with estimating, aggregating and evaluating the magnitude of risks. Regarding the locations in which uncertainty is manifest, data uncertainty is dominant in problem formulation, exposure assessment and effects assessment. The comprehensive description of uncertainty described will enable risk analysts to prioritise the required phases, groups of tasks, or individual tasks within a risk analysis according to the highest levels of uncertainty, the potential for uncertainty to be reduced or quantified, or the types of location-based uncertainty, thus aiding uncertainty prioritisation during environmental risk assessments. In turn, it is expected to inform investment in uncertainty reduction or targeted risk management action

Did GW170817 harbor a pulsar?

If the progenitor of GW170817 harbored a pulsar, then a Poynting flux dominated bow-shock cavity would have been expected to form around the traveling binary. The characteristic size of this evacuated region depends strongly on the spin-down evolution of the pulsar companion, which in turn depends on the merging timescale of the system. If this evacuated region is able to grow to a sufficiently large scale, then the deceleration of the jet, and thus the onset of the afterglow, would be noticeably delayed. The first detection of afterglow emission, which was uncovered 9.2 days after the $\gamma$-ray burst trigger, can thus be used to constrain the size of a pre-existing pulsar-wind cavity. We use this information, together with a model of the jet to place limits on the presence of a pulsar in GW170817 and discuss the derived constraints in the context of the observed double neutron star binary population. We find that the majority of Galactic systems that are close enough to merge within a Hubble time would have carved a discernibly large pulsar-wind cavity, inconsistent with the onset timescale of the X-ray afterglow of GW170817. Conversely, the recently detected system J1913+1102, which host a low-luminosity pulsar, provides a congruous Milky Way analog of GW170817's progenitor model. This study highlights the potential of the proposed observational test for gaining insight into the origin of double neutron star binaries, in particular if the properties of Galactic systems are representative of the overall merging population.Comment: Accepted for publication in ApJL, 6 pages, 5 figure