911 research outputs found
Isolation of host-range variants of mouse mammary tumor viruses that efficiently infect cells in vitro
Host-range variants of mouse mammary tumor virus (MMTV) have been isolated that have the ability to productively infect cells in vitro with high efficiency (at multiplicities of infection ≤1) and with extremely short latent periods to the production of de novo virus (as short as 4 days after infection). These variants of the highly oncogenic MMTV of RIII, C3H, and GR mice were obtained by serial virus passage in feline cells. The resultant variant stocks react in group-specific radioimmunoassays for the MMTV major external glycoprotein (gp52) and major internal protein (p28), possess a protein profile similar to that of wild-type MMTV, and contain a virion-associated DNA polymerase with a magnesium cation preference. Addition of dexamethasone and insulin to culture media enhances the titer of de novo MMTV to levels of approximately 10(10) particles per 75-cm(2) flask (containing 5 × 10(6) cells) per 24 hr. Variant stocks exhibit no evidence of contamination with either murine or feline type C retroviruses, as assayed by various techniques. The variants of MMTV derived from C3H and RIII mice exhibit differential host ranges that include the ability to productively infect feline, canine, bat, mink, murine, and human cells. Use of these MMTV host-range variants now facilitates the study of the complete replicative cycle of MMTV as well as an elucidation of the interaction of MMTV with various hormones, physical or chemical carcinogens, and tumor promoters in the initiation and promotion of mammary neoplasia
Si-compatible candidates for high-K dielectrics with the Pbnm perovskite structure
We analyze both experimentally (where possible) and theoretically from
first-principles the dielectric tensor components and crystal structure of five
classes of Pbnm perovskites. All of these materials are believed to be stable
on silicon and are therefore promising candidates for high-K dielectrics. We
also analyze the structure of these materials with various simple models,
decompose the lattice contribution to the dielectric tensor into force constant
matrix eigenmode contributions, explore a peculiar correlation between
structural and dielectric anisotropies in these compounds and give phonon
frequencies and infrared activities of those modes that are infrared-active. We
find that CaZrO_3, SrZrO_3, LaHoO_3, and LaYO_3 are among the most promising
candidates for high-K dielectrics among the compounds we considered.Comment: 17 pages, 9 figures, 4 tables. Supplementary information:
http://link.aps.org/supplemental/10.1103/PhysRevB.82.064101 or
http://www.physics.rutgers.edu/~sinisa/highk/supp.pd
Quantifying electronic correlation strength in a complex oxide: a combined DMFT and ARPES study of LaNiO
The electronic correlation strength is a basic quantity that characterizes
the physical properties of materials such as transition metal oxides.
Determining correlation strengths requires both precise definitions and a
careful comparison between experiment and theory. In this paper we define the
correlation strength via the magnitude of the electron self-energy near the
Fermi level. For the case of LaNiO, we obtain both the experimental and
theoretical mass enhancements by considering high resolution
angle-resolved photoemission spectroscopy (ARPES) measurements and density
functional + dynamical mean field theory (DFT + DMFT) calculations. We use
valence-band photoemission data to constrain the free parameters in the theory,
and demonstrate a quantitative agreement between the experiment and theory when
both the realistic crystal structure and strong electronic correlations are
taken into account. These results provide a benchmark for the accuracy of the
DFT+DMFT theoretical approach, and can serve as a test case when considering
other complex materials. By establishing the level of accuracy of the theory,
this work also will enable better quantitative predictions when engineering new
emergent properties in nickelate heterostructures.Comment: 10 pages, 5 figure
Doping evolution and polar surface reconstruction of the infinite-layer cuprate SrLaCuO
We use angle-resolved photoemission spectroscopy to study the doping
evolution of infinite-layer SrLaCuO thin films grown by
molecular-beam epitaxy. At low doping, the material exhibits a dispersive lower
Hubbard band typical of the superconducting cuprate parent compounds. As
carriers are added to the system, a continuous evolution from charge-transfer
insulator to superconductor is observed, with the initial lower Hubbard band
pinned well below the Fermi level and the development of a coherent low-energy
band with electron doping. This two-component spectral function emphasizes the
important role that strong local correlations play even at relatively high
doping levels. Electron diffraction probes reveal a surface
reconstruction of the material at low doping levels. Using a number of simple
assumptions, we develop a model of this reconstruction based on the polar
nature of the infinite-layer structure. Finally, we provide evidence for a
thickness-controlled transition in ultrathin films of SrCuO grown on
nonpolar SrTiO, highlighting the diverse structural changes that can occur
in polar complex oxide thin films
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