Conceptual Dependency and the Clausal Structure of Discourse

Wetensch. publicatieFaculteit der Lettere

Functionele elementen in een cognitief perspectief

Wetensch. publicatieFaculteit der Lettere

Modelling socio-technical transition patterns and pathways

We report on research that is developing a simulation model for assessing systemic innovations, or 'transitions', of societal systems towards a more sustainable development. Our overall aim is to outline design principles for models that can offer new insights into tackling persistent problems in large-scale systems, such as the European road transport system or the regional management of water resources. The systemic nature of these problems is associated with them being complex, uncertain and cutting across a number of sectors, and indicates a need for radical technological and behavioural solutions that address changes at the systems level rather than offering incremental changes within sub-systems. Model design is inspired by recent research into transitions, an emerging paradigm which provides a framework for tackling persistent problems. We use concepts from the literature on transitions to develop a prototype of a generic 'transition model'. Our prototype aims to capture different types of transition pathways, using historical examples such as the transition from horse-drawn carriages to cars or that from sailing ships to steam ships. The model combines agent-based modelling techniques and system dynamics, and includes interactions of individual agents and sub-systems, as well as cumulative effects on system structures. We show success in simulating different historical transition pathways by adapting the model's parameters and rules for each example. Finally, we discuss the improvements necessary for systematically exploring and detailing transition pathways in empirical case-study applications to current and future transitions such as the transition to a sustainable transport system in Europe

Participatory modelling for the integrated sustainability assessment of water: The World Cellular Model and the MATISSE project

This paper describes the participatory process of developing and implementing a prototype model aimed at supporting the Integrated Sustainability Assessment of water resources and policy options at different scales. The model - called the World Cellular Model (WCM) focuses on the representation of agents’ behaviours and their systemic relationships with their environment. This is achieved by examining the interests, motives, cultural beliefs and structural resources that drive agents’ actions with regard to the use of stocks and flows of water, by looking at the impact of such water behaviours on the environment and on the natural ecosystems at different scales, and by examining in a coevolutionary way the impact of such environmental changes on the behaviours of agents. The WC model takes a ‘total system’, multi-scale, agent perspective. That is, agents operate in a single interrelated system in which each individual or collective agent responds to the availability and use of a set of stocks and flows of rules and/or institutions (S), energy and resources (E), information and knowledge (I) that in turn provokes environmental change (C) or impact on the social ecological system. . This model is being developed together with the use of participatory Integrated Assessment focus groups (IA-fgs) with real stakeholders to get insights about agents’ behaviours and the possible architecture of the model so as to increase its socio-ecological robustness and policy relevance. Our research is part of the EU funded project Matisse (Methods and Tools for Integrated Sustainability Assessment)

Dysregulated signaling, proliferation and apoptosis impact on the pathogenesis of TCRγδ+ T cell large granular lymphocyte leukemia

TCRγδ+ T-LGL leukemia is a rare form of chronic mature T cell disorders in elderly, which is generally characterized by a persisten

miR-181a is a novel player in the STAT3-mediated survival network of TCRαβ+ CD8+ T large granular lymphocyte leukemia

T-LGL cells arise as a consequence of chronic antigenic stimulation and inflammation and thrive because of constitutive activation of the STAT3 and ERK pathway. Notably, in 40% of patients, constitutive STAT3 activation is due to STAT3 activating mutations, whereas in 60% this is unknown. As miRNAs are amongst the most potent regulators in health and disease, we hypothesized that aberrant miRNA expression could contribute to dysregulation of these pathways. miRNA sequencing in T-LGL leukemia cases and aged-matched healthy control TEMRA cells revealed overexpression of miR-181a. Furthermore, geneset enrichment analysis (GSEA) of downregulated targets of miR-181a implicated involvement in regulating STAT3 and ERK1/2 pathways. Flow cytometric analyses showed increased SOCS3+ and DUSP6+ T-LGL cells upon miR-181a inhibition. In addition, miR-181a-transfected human CD8+ T cells showed increased basal STAT3 and ERK1/2 phosphorylation. By using TL1, a human T-LGL cell line, we could show that miR-181a is an actor in T-LGL leukemia, driving STAT3 activation by SOCS3 inhibition and ERK1/2 phosphorylation by DUSP6 inhibition and verified this mechanism in an independent cell line. In addition, miR-181a inhibition resulted in a higher sensitivity to FAS-mediated apoptosis. Collectively, our data show that miR-181a could be the missing link to explain why STAT3-unmutated patients show hyperactive STAT3

Modelling societal transitions with agent transformation

Transition models explain long-term and large-scale processes fundamentally changing the structure of a societal system. Our concern is that most transition models are too static. Although they capture a move of focus from static equilibria to transitions between dynamic equilibria, they are still rooted in an "equilibriumist" approach. Improvement is possible with agent-based models that give attention to endogenous system processes called "transformation processes". These models can render far more dynamic pictures of societal systems in transition, and are no longer remote from descriptions in the emerging transition literature

Modelización participativa para la evaluación integrada de la sostenibilidad de los recursos hídricos: el Modelo del Mundo Celular y el Proyecto Matisse

El presente trabajo describe el proceso participativo vinculado al desarrollo y la implementación del prototipo de un modelo que tiene como principal objetivo servir de soporte durante el procesos de Evaluación Integrada de la Sostenibilidad (EIS) de diferentes opciones políticas de gestión de los recursos hídricos a diferentes niveles de acción. El modelo – llamado el Modelo del Mundo Celular (MMC) – se centra en la representación del comportamiento de los agentes respecto a sus relaciones sistemáticas con el medio ambiente. Esto se consigue principalmente mediante el análisis tres aspectos. En primer lugar, se analizan los intereses, motivaciones, creencias culturales y otras condiciones estructurales que condicionan la conducta de los agentes en el usos de las reservas y flujos de agua. Segundo, mediante el estudio a diferentes escalas del impacto sobre los ecosistemas naturales y el medio ambiente en general del comportamiento de los usuarios. Por último, se realiza de forma co-evolutiva el análisis del impacto de esos cambios ambientales en el comportamiento de los agentes. El MCM utiliza una perspectiva integrada, multi-escalar y basada en agentes. Los agentes operan en un único sistema interrelacionado en el cual cada individuo o agente colectivo responde a su disponibilidad y uso de un conjunto de reservas y flujos de reglas sociales e instituciones (S), energía y recursos (E) información y conocimiento (I), que a su vez provocan impactos y cambios (C) en el sistema socio-ecológico. Este modelo se está desarrollando conjuntamente con Grupos de Discusión como parte de un proceso de Evaluación Integrada participativa. En el proceso de participación intervienen actores reales involucrados en la gestión del agua que aportan su conocimiento sobre el comportamiento de los agentes y la posible arquitectura del modelo para incrementar su robustez social y su relevancia política. Nuestra investigación forma parte del proyecto MATISSE (Methods and Tools for Integrated Sustainability Assessment)financiado por la Unión Europea.This paper describes the participatory process of developing and implementing a prototype model. This model is aimed at supporting integrated sustainability assessment (ISA) of policy options for managing water resources at different levels of action. The model is called the World Cellular Model (WCM). It represents agents’ behaviour in terms of their systemic relationships with the environment. This is achieved by examining three aspects. Firstly, we analyse the interests, motives, cultural beliefs and other structural conditions that drive agents’ actions with regard to their use of reserves and flows of water. Secondly, we examine different levels of the impact of agents’ behaviour on the environment and on natural ecosystems. Thirdly, we analyse in a coevolutionary way the impact of such environmental changes on the behaviour of agents. The WCM uses an integrated, multi-scale, agent-based perspective. Agents operate in a single interrelated system in which each individual or collective agent responds to the availability and use of a set of reserves and flows of social rules and/or institutions (S), energy and resources (E), information and knowledge (I) that in turn provokes environmental change (C) or impact on the social ecological system. This model is being developed with the collaboration of discussion groups, as part of a participatory integrated assessment process. Groups include people who are involved in water management. These group members have insight into agents’ behaviour and the possible architecture of the model. Their contributions can help to increase the model’s socio-ecological robustness and policy relevance. Our research is part of the EU-funded project MATISSE (Methods and Tools for Integrated Sustainability Assessment)

Modelización participativa para la evaluación integrada de la sostenibilidad de los recursos hídricos : el modelo del mundo celular y el proyecto matisse

El presente trabajo describe el proceso participativo vinculado al desarrollo y la implementación del prototipo de un modelo que tiene como principal objetivo servir de soporte durante el procesos de Evaluación Integrada de la Sostenibilidad (EIS) de diferentes opciones políticas de gestión de los recursos hídricos a diferentes niveles de acción. El modelo - llamado el Modelo del Mundo Celular (MMC) - se centra en la representación del comportamiento de los agentes respecto a sus relaciones sistemáticas con el medio ambiente. Esto se consigue principalmente mediante el análisis tres aspectos. En primer lugar, se analizan los intereses, motivaciones, creencias culturales y otras condiciones estructurales que condicionan la conducta de los agentes en el usos de las reservas y flujos de agua. Segundo, mediante el estudio a diferentes escalas del impacto sobre los ecosistemas naturales y el medio ambiente en general del comportamiento de los usuarios. Por último, se realiza de forma co-evolutiva el análisis del impacto de esos cambios ambientales en el comportamiento de los agentes. El MCM utiliza una perspectiva integradamulti-escalar y basada en agentes. Los agentes operan en un único sistema interrelacionado en el cual cada individuo o agente colectivo responde a su disponibilidad y uso de un conjunto de reservas y flujos de reglas sociales e instituciones (S), energía y recursos (E) información y conocimiento (I), que a su vez provocan impactos y cambios (C) en el sistema socio-ecológico. Este modelo se está desarrollando conjuntamente con Grupos de Discusión como parte de un proceso de Evaluación Integrada participativa. En el proceso de participación intervienen actores reales involucrados en la gestión del agua que aportan su conocimiento sobre el comportamiento de los agentes y la posible arquitectura del modelo para incrementar su robustez social y su relevancia política. Nuestra investigación forma parte del proyecto MATISSE (Methods and Tools for Integrated Sustainability Assessment) financiado por la Unión Europea