Small world characteristics of FLOSS distributions

Over the years, Free/Libre Open Source Software (FLOSS) distributions have become more and more complex and recent versions contain tens of thousands of packages. This has made it impossible to do quality control by hand. Instead, distribution editors must look to automated methods to ensure the quality of their distributions. In the present paper, we present some insights into the general structure of FLOSS distributions. We notably show that such distributions have the characteristics of a small world network: there are only a few important packages, and many less important packages. Identifying the important packages can help editors focus their efforts on parts of the distribution where errors will have important consequences

Collapse of the Cooper pair phase coherence length at a superconductor to insulator transition

We present investigations of the superconductor to insulator transition (SIT) of uniform a-Bi films using a technique sensitive to Cooper pair phase coherence. The films are perforated with a nanohoneycomb array of holes to form a multiply connected geometry and subjected to a perpendicular magnetic field. Film magnetoresistances on the superconducting side of the SIT oscillate with a period dictated by the superconducting flux quantum and the areal hole density. The oscillations disappear close to the SIT critical point to leave a monotonically rising magnetoresistance that persists in the insulating phase. These observations indicate that the Cooper pair phase coherence length, which is infinite in the superconducting phase, collapses to a value less than the interhole spacing at this SIT. This behavior is inconsistent with the gradual reduction of the phase coherence length expected for a bosonic, phase fluctuation driven SIT. This result starkly contrasts with previous observations of oscillations persisting in the insulating phase of other films implying that there must be at least two distinct classes of disorder tuned SITs

Modular classes of Poisson-Nijenhuis Lie algebroids

The modular vector field of a Poisson-Nijenhuis Lie algebroid $A$ is defined and we prove that, in case of non-degeneracy, this vector field defines a hierarchy of bi-Hamiltonian $A$-vector fields. This hierarchy covers an integrable hierarchy on the base manifold, which may not have a Poisson-Nijenhuis structure.Comment: To appear in Letters in Mathematical Physic

Optical and Near Infrared Study of the Cepheus E outflow, a very low excitation object

We present images and spectra of the Cepheus E (Cep E) region at both optical and infrared wavelengths. Only the brightest region of the southern lobe of the Cep E outflow reveals optical emission, suggesting that the extinction close to the outflow source plays an important r\^ole in the observed difference between the optical and IR morphologies. Cep E is a unique object since it provides a link between the spectroscopic properties of the optical Herbig-Haro (HH) objects and those of deeply embedded outflows.Comment: Accepted Astron. J., 8 files: paper, tables plus 6 figure

A reporter for amyloid precursor protein γ-secretase activity in Drosophila

A key event in the pathogenesis of Alzheimer's disease (AD) is the deposition of senile plaques consisting largely of a peptide known as β-amyloid (Aβ) that is derived from the amyloid precursor protein (APP). A proteolytic activity called γ-secretase cleaves APP in the transmembrane domain and is required for Aβ generation. Aberrant γ-secretase cleavage of APP underlies the majority of early onset, familial AD. γ-Secretase resides in a large multi-protein complex, of which Presenilin, Nicastrin, APH-1 and PEN-2 are four essential components. Thus, identifying components and pathways by which the γ-secretase activity is regulated is crucial to understanding the mechanisms underlying AD pathogenesis, and may provide new diagnostic tools and therapeutic targets. Here we describe the generation of Drosophila that act as living reporters of γ-secretase activity in the fly eye. In these reporter flies the size of the eye correlates with the level of endogenous γ-secretase activity, and is very sensitive to the levels of three genes required for APP γ-secretase activity, presenilin, nicastrin and aph-1. Thus, these flies provide a sensitized system with which to identify other components of the γ-secretase complex and regulators of its activity. We have used these flies to carry out a screen for mutations that suppress γ-secretase activity and have identified a small chromosomal region that contains a gene or genes whose products may promote γ-secretase activity

System and market failures: the unavailability of magnesium sulphate for the treatment of eclampsia and pre-eclampsia in Mozambique and Zimbabwe.

Low cost and effective drugs, such as magnesium sulphate, need to be included in initiatives to improve access to essential medicines in Afric

Clinical, histological and prognostic features of a novel nail-bed lesion of cats: 41 cases

There is a distinct subset of lesions arising on the digits of cats, located at or close to the nail-bed epithelium, which are typically composed of proliferative fibroblast-like cells, multinucleate giant cells and areas of osseous metaplasia, but currently there is no published literature detailing the clinical or histological features of these lesions. This study identified 41 such cases from two large commercial diagnostic laboratories and assessed various histological and clinical features; 22 cases had additional follow-up data available