Internal screening and dielectric engineering in magic-angle twisted bilayer graphene

Magic-angle twisted bilayer graphene (MA-tBLG) has appeared as a tunable testing ground to investigate the conspiracy of electronic interactions, band structure, and lattice degrees of freedom to yield exotic quantum many-body ground states in a two-dimensional Dirac material framework. While the impact of external parameters such as doping or magnetic field can be conveniently modified and analyzed, the all-surface nature of the quasi-2D electron gas combined with its intricate internal properties pose a challenging task to characterize the quintessential nature of the different insulating and superconducting states found in experiments. We analyze the interplay of internal screening and dielectric environment on the intrinsic electronic interaction profile of MA-tBLG. We find that interlayer coupling generically enhances the internal screening. The influence of the dielectric environment on the effective interaction strength depends decisively on the electronic state of MA-tBLG. Thus, we propose the experimental tailoring of the dielectric environment, e.g. by varying the capping layer composition and thickness, as a promising pursuit to provide further evidence for resolving the hidden nature of the quantum many-body states in MA-tBLG.Comment: 9 pages, 3 figures, supplemental material included (8 figures

IL7RA haplotype-associated alterations in cellular immune function and gene expression patterns in multiple sclerosis

Interleukin-7 receptor alpha (IL7RA) is among the top listed candidate genes influencing the risk to develop multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Soluble IL-7RA (sIL-7RA) protein and mRNA levels vary among the four common IL7RA haplotypes. Here we show and confirm that protective haplotype carriers have three times lower sIL-7RA serum levels than the other three haplotypes. High sIL-7RA concentrations significantly decrease IL-7-mediated STAT5 phosphorylation in CD4(+) T cells. Transcriptome analysis of unstimulated and stimulated CD4(+) T cells of MS patients carrying the different IL7RA haplotypes revealed complex and overlapping patterns in genes participating in cytokine signaling networks, apoptosis, cell cycle progression and cell differentiation. Our findings indicate that genetic variants of IL7RA result in haplotype-associated differential responsiveness to immunological stimuli that influence MS susceptibility not exclusively by varying levels of sIL-7RA

Intrauterine instillation of diluted seminal plasma at oocyte pick-up does not increase the IVF pregnancy rate: a double-blind, placebo controlled, randomized study

STUDY QUESTION Does intrauterine application of diluted seminal plasma (SP) at the time of ovum pick-up improve the pregnancy rate by ≥14% in IVF treatment? SUMMARY ANSWER Intrauterine instillation of diluted SP at the time of ovum pick-up is unlikely to increase the pregnancy rate by ≥14% in IVF. WHAT IS KNOWN ALREADY SP modulates endometrial function, and sexual intercourse around the time of embryo transfer has been suggested to increase the likelihood of pregnancy. A previous randomized double-blind pilot study demonstrated a strong trend towards increased pregnancy rates following the intracervical application of undiluted SP. As this study was not conclusive and as the finding could have been confounded by sexual intercourse, the intrauterine application of diluted SP was investigated in the present trial. STUDY DESIGN, SIZE, DURATION A single-centre, prospective, double-blind, placebo-controlled, randomized, superiority trial on women undergoing IVF was conducted from April 2007 until February 2012 at the University Department of Gynaecological Endocrinology and Reproductive Medicine, Heidelberg, Germany. PARTICIPANTS/MATERIALS, SETTING, METHODS The study was powered to detect an 14% increase in the clinical pregnancy rate and two sequential tests were planned using the Pocock spending function. At the first interim analysis, 279 women had been randomly assigned to intrauterine diluted SP (20% SP in saline from the patients' partner) (n = 138) or placebo (n = 141) at the time of ovum pick-up. MAIN RESULTS AND THE ROLE OF CHANCE The clinical pregnancy rate per randomized patient was 37/138 (26.8%) in the SP group and 41/141 (29.1%) in the placebo group (difference: −2.3%, 95% confidence interval of the difference: −12.7 to +8.2%; P = 0.69). The live birth rate per randomized patient was 28/138 (20.3%) in the SP group and 33/141 (23.4%) in the placebo group (difference: −3.1%, 95% confidence interval of the difference: −12.7 to +6.6%; P = 0.56). It was decided to terminate the trial due to futility at the first interim analysis, at a conditional power of 62%. LIMITATIONS, REASONS FOR CAUTION The confidence interval of the difference remains wide, thus clinically relevant differences cannot reliably be excluded based on this single study. WIDER IMPLICATIONS OF THE FINDINGS The results of this study cast doubt on the validity of the concept that SP increases endometrial receptivity and thus implantation in humans. STUDY FUNDING/COMPETING INTEREST(S) Funding was provided by the department's own research facilities. TRIAL REGISTRATION NUMBER DRKS0000461

Observation Needs for Climate Services and Research

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The helium atom in a strong magnetic field

We investigate the electronic structure of the helium atom in a magnetic field b etween B=0 and B=100a.u. The atom is treated as a nonrelativistic system with two interactin g electrons and a fixed nucleus. Scaling laws are provided connecting the fixed-nucleus Hamiltonia n to the one for the case of finite nuclear mass. Respecting the symmetries of the electronic Ham iltonian in the presence of a magnetic field, we represent this Hamiltonian as a matrix with res pect to a two-particle basis composed of one-particle states of a Gaussian basis set. The corresponding generalized eigenvalue problem is solved numerically, providing in the present paper results for vanish ing magnetic quantum number M=0 and even or odd z-parity, each for both singlet and triplet spin symmetry. Total electronic energies of the ground state and the first few excitations in each su bspace as well as their one-electron ionization energies are presented as a function of the magnetic fie ld, and their behaviour is discussed. Energy values for electromagnetic transitions within the M=0 sub space are shown, and a complete table of wavelengths at all the detected stationary points with respect to their field dependence is given, thereby providing a basis for a comparison with observed ab sorption spectra of magnetic white dwarfs.Comment: 21 pages, 4 Figures, acc.f.publ.in J.Phys.