The onset of solar cycle 24: What global acoustic modes are telling us

We study the response of the low-degree, solar p-mode frequencies to the unusually extended minimum of solar surface activity since 2007. A total of 4768 days of observations collected by the space-based, Sun-as-a-star helioseismic GOLF instrument are analyzed. A multi-step iterative maximum-likelihood fitting method is applied to subseries of 365 days and 91.25 days to extract the p-mode parameters. Temporal variations of the l=0, 1, and 2 p-mode frequencies are then obtained from April 1996 to May 2009. While the p-mode frequency shifts are closely correlated with solar surface activity proxies during the past solar cycles, the frequency shifts of the l=0 and l=2 modes show an increase from the second half of 2007, when no significant surface activity is observable. On the other hand, the l=1 modes follow the general decreasing trend of the solar surface activity. The different behaviours between the l=0 and l=2 modes and the l=1 modes can be interpreted as different geometrical responses to the spatial distribution of the solar magnetic field beneath the surface of the Sun. The analysis of the low-degree, solar p-mode frequency shifts indicates that the solar activity cycle 24 started late 2007, despite the absence of activity on the solar surface.Comment: To be accepted by A&A (with minor revisions), 4 pages, 3 figures, 1 tabl

Automation on the generation of genome scale metabolic models

Background: Nowadays, the reconstruction of genome scale metabolic models is a non-automatized and interactive process based on decision taking. This lengthy process usually requires a full year of one person's work in order to satisfactory collect, analyze and validate the list of all metabolic reactions present in a specific organism. In order to write this list, one manually has to go through a huge amount of genomic, metabolomic and physiological information. Currently, there is no optimal algorithm that allows one to automatically go through all this information and generate the models taking into account probabilistic criteria of unicity and completeness that a biologist would consider. Results: This work presents the automation of a methodology for the reconstruction of genome scale metabolic models for any organism. The methodology that follows is the automatized version of the steps implemented manually for the reconstruction of the genome scale metabolic model of a photosynthetic organism, {\it Synechocystis sp. PCC6803}. The steps for the reconstruction are implemented in a computational platform (COPABI) that generates the models from the probabilistic algorithms that have been developed. Conclusions: For validation of the developed algorithm robustness, the metabolic models of several organisms generated by the platform have been studied together with published models that have been manually curated. Network properties of the models like connectivity and average shortest mean path of the different models have been compared and analyzed.Comment: 24 pages, 2 figures, 2 table

The current status of hepatic transplantation at the University of Pittsburgh.

Tacrolimus is a more potent and satisfactory immunosuppressant than CyA for combination therapy with prednisone. In randomized trials comparing the 2 drugs, the ability of tacrolimus to rescue intractably rejecting grafts on the competing CyA arm allowed equalization of patient and graft survival on both arms when the intent-to-treat analytic methodology was applied. The ability of tacrolimus to systematically rescue the treatment failures of CyA suggested, as a matter of common sense, that it is the preferred baseline drug for hepatic transplantation. This conclusion was supported by analysis of secondary end points, including the ability to prevent rejection. Hepatic-intestinal, multivisceral and isolated intestinal transplantation became feasible on a practical basis only after the advent of tacrolimus. Nevertheless, better management strategies must be devised before intestinal transplantation, alone or with other abdominal viscera, will meet its potential. One such strategy is based on the discovery of the presence of previously unsuspected, low-level donor leukocyte chimerism in long-surviving allograft recipients. We believe that this chimerism is the essential explanation for the feasibility of organ transplantation and a link to the acquired neonatal tolerance demonstrated by Billingham, Brent and Medawar (32). The hematolymphopoietic chimerism in organ recipients explains why weaning to a drug-free state in selected long-term survivors is frequently feasible and particularly if the allograft is a liver. Weaning should never be attempted without a stepwise protocol and careful monitoring of graft function. Recognition of the natural chimerism that develops after whole organ transplantation has led to efforts to augment it with perioperative donor BM infusion. This procedure has been shown to be free of significant complications (including GVHD) in all kinds of whole organ recipients, including those given intestine. The prospects of clinical xenotransplantation must be evaluated in the same context of chimerism as that delineated for allotransplantation with the discovery of spontaneous chimerism. Before addressing chimerism-related questions in xenotransplantation, the additional barrier of the complement activation syndromes that cause hyperacute rejection will have to be surmounted. Although measures to effectively transplant xenografts have so far eluded us, the availability of the more potent drug, tacrolimus, and recognition of the seminal basis of allograft (or xenograft) acceptance via chimerism has inserted an element of reality into the largely wishful thinking that has been evident in discussions about the future of xenotransplantation

Quantum critical dynamics of a S = 1/2 antiferromagnetic Heisenberg chain studied by 13C-NMR spectroscopy

We present a 13C-NMR study of the magnetic field driven transition to complete polarization of the S=1/2 antiferromagnetic Heisenberg chain system copper pyrazine dinitrate Cu(C_4H_4N_2)(NO_3)_2 (CuPzN). The static local magnetization as well as the low-frequency spin dynamics, probed via the nuclear spin-lattice relaxation rate 1/T_1, were explored from the low to the high field limit and at temperatures from the quantum regime (k_B T << J) up to the classical regime (k_B T >> J). The experimental data show very good agreement with quantum Monte Carlo calculations over the complete range of parameters investigated. Close to the critical field, as derived from static experiments, a pronounced maximum in 1/T_1 is found which we interpret as the finite-temperature manifestation of a diverging density of zero-energy magnetic excitations at the field-driven quantum critical point.Comment: 5 pages, 4 figure

Detection of periodic signatures in the solar power spectrum. On the track of l=1 gravity modes

In the present work we show robust indications of the existence of g modes in the Sun using 10 years of GOLF data. The present analysis is based on the exploitation of the collective properties of the predicted low-frequency (25 to 140 microHz) g modes: their asymptotic nature, which implies a quasi equidistant separation of their periods for a given angular degree (l). The Power Spectrum (PS) of the Power Spectrum Density (PSD), reveals a significant structure indicating the presence of features (peaks) in the PSD with near equidistant periods corresponding to l=1 modes in the range n=-4 to n=-26. The study of its statistical significance of this feature was fully undertaken and complemented with Monte Carlo simulations. This structure has a confidence level better than 99.86% not to be due to pure noise. Furthermore, a detailed study of this structure suggests that the gravity modes have a much more complex structure than the one initially expected (line-widths, magnetic splittings...). Compared to the latest solar models, the obtained results tend to favor a solar core rotating significantly faster than the rest of the radiative zone. In the framework of the Phoebus group, we have also applied the same methodology to other helioseismology instruments on board SoHO and ground based networks.Comment: Proceedings of the SOHO-18/GONG2006/HELAS I: Beyond the spherical Su