16,389 research outputs found
Reaction of O/1D/ with N2O
Reaction of excited oxygen with nitrous oxide 1 yielding nitrogen and oxyge
PriPeARL: A Framework for Privacy-Preserving Analytics and Reporting at LinkedIn
Preserving privacy of users is a key requirement of web-scale analytics and
reporting applications, and has witnessed a renewed focus in light of recent
data breaches and new regulations such as GDPR. We focus on the problem of
computing robust, reliable analytics in a privacy-preserving manner, while
satisfying product requirements. We present PriPeARL, a framework for
privacy-preserving analytics and reporting, inspired by differential privacy.
We describe the overall design and architecture, and the key modeling
components, focusing on the unique challenges associated with privacy,
coverage, utility, and consistency. We perform an experimental study in the
context of ads analytics and reporting at LinkedIn, thereby demonstrating the
tradeoffs between privacy and utility needs, and the applicability of
privacy-preserving mechanisms to real-world data. We also highlight the lessons
learned from the production deployment of our system at LinkedIn.Comment: Conference information: ACM International Conference on Information
and Knowledge Management (CIKM 2018
The chameleon groups of Richard J. Thompson: automorphisms and dynamics
The automorphism groups of several of Thompson's countable groups of
piecewise linear homeomorphisms of the line and circle are computed and it is
shown that the outer automorphism groups of these groups are relatively small.
These results can be interpreted as stability results for certain structures of
PL functions on the circle. Machinery is developed to relate the structures on
the circle to corresponding structures on the line
Tidal Evolution of Close-in Extra-Solar Planets
The distribution of eccentricities e of extra-solar planets with semi-major
axes a > 0.2 AU is very uniform, and values for e are relatively large,
averaging 0.3 and broadly distributed up to near 1. For a < 0.2 AU,
eccentricities are much smaller (most e < 0.2), a characteristic widely
attributed to damping by tides after the planets formed and the protoplanetary
gas disk dissipated. Most previous estimates of the tidal damping considered
the tides raised on the planets, but ignored the tides raised on the stars.
Most also assumed specific values for the planets' poorly constrained tidal
dissipation parameter Qp. Perhaps most important, in many studies, the strongly
coupled evolution between e and a was ignored. We have now integrated the
coupled tidal evolution equations for e and a over the estimated age of each
planet, and confirmed that the distribution of initial e values of close-in
planets matches that of the general population for reasonable Q values, with
the best fits for stellar and planetary Q being ~10^5.5 and ~10^6.5,
respectively. The accompanying evolution of a values shows most close-in
planets had significantly larger a at the start of tidal migration. The earlier
gas disk migration did not bring all planets to their current orbits. The
current small values of a were only reached gradually due to tides over the
lifetimes of the planets. These results may have important implications for
planet formation models, atmospheric models of "hot Jupiters", and the success
of transit surveys.Comment: accepted to Ap
Molecular determinants of drug-specific sensitivity for epidermal growth factor receptor (EGFR) exon 19 and 20 mutants in non-small cell lung cancer.
We hypothesized that aberrations activating epidermal growth factor receptor (EGFR) via dimerization would be more sensitive to anti-dimerization agents (e.g., cetuximab). EGFR exon 19 abnormalities (L747_A750del; deletes amino acids LREA) respond to reversible EGFR kinase inhibitors (TKIs). Exon 20 in-frame insertions and/or duplications (codons 767 to 774) and T790M mutations are clinically resistant to reversible/some irreversible TKIs. Their impact on protein function/therapeutic actionability are not fully elucidated.In our study, the index patient with non-small cell lung cancer (NSCLC) harbored EGFR D770_P772del_insKG (exon 20). A twenty patient trial (NSCLC cohort) (cetuximab-based regimen) included two participants with EGFR TKI-resistant mutations ((i) exon 20 D770>GY; and (ii) exon 19 LREA plus exon 20 T790M mutations). Structural modeling predicted that EGFR exon 20 anomalies (D770_P772del_insKG and D770>GY), but not T790M mutations, stabilize the active dimer configuration by increasing the interaction between the kinase domains, hence sensitizing to an agent preventing dimerization. Consistent with predictions, the two patients harboring D770_P772del_insKG and D770>GY, respectively, responded to an EGFR antibody (cetuximab)-based regimen; the T790M-bearing patient showed no response to cetuximab combined with erlotinib. In silico modeling merits investigation of its ability to optimize therapeutic selection based on structural/functional implications of different aberrations within the same gene
Molecular and mass spectroscopic analysis of isotopically labeled organic residues
Experimental studies aimed at understanding the evolution of complex organic molecules on interstellar grains were performed. The photolysis of frozen gas mixtures of various compositions containing H2O, CO, NH3, and CH4 was studied. These species were chosen because of their astrophysical importance as deducted from observational as well as theoretical studies of ice mantles on interstellar grains. These ultraviolet photolyzed ices were warmed up in order to produce refractory organic molecules like the ones formed in molecular clouds when the icy mantles are being irradiated and warmed up either by a nearby stellar source or impulsive heating. The laboratory studies give estimates of the efficiency of production of such organic material under interstellar conditions. It is shown that the gradual carbonization of organic mantles in the diffuse cloud phase leads to higher and higher visual absorptivity - yellow residues become brown in the laboratory. The obtained results can be applied to explaining the organic components of comets and their relevance to the origin of life
P02-05. All-trans retinoic acid during vaccination increases Ag-specific CD8 T cell homing to mucosal sites and improves recall responses to vaginal challenge
Synchronized flow and wide moving jams from balanced vehicular traffic
Recently we proposed an extension to the traffic model of Aw, Rascle and
Greenberg. The extended traffic model can be written as a hyperbolic system of
balance laws and numerically reproduces the reverse shape of the
fundamental diagram of traffic flow. In the current work we analyze the steady
state solutions of the new model and their stability properties. In addition to
the equilibrium flow curve the trivial steady state solutions form two
additional branches in the flow-density diagram. We show that the
characteristic structure excludes parts of these branches resulting in the
reverse shape of the flow-density relation. The upper branch is
metastable against the formation of synchronized flow for intermediate
densities and unstable for high densities, whereas the lower branch is unstable
for intermediate densities and metastable for high densities. Moreover, the
model can reproduce the typical speed of the downstream front of wide moving
jams. It further reproduces a constant outflow from wide moving jams, which is
far below the maximum free flow. Applying the model to simulate traffic flow at
a bottleneck we observe a general pattern with wide moving jams traveling
through the bottleneck.Comment: 10 pages, 12 figure
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