Resonances in 19Ne with relevance to the astrophysically important 18F(p,{\alpha})15O reaction

The most intense gamma-ray line observable from novae is likely to be from positron annihilation associated with the decay of 18F. The uncertainty in the destruction rate of this nucleus through the 18F(p,{\alpha})15O reaction presents a limit to interpretation of any future observed gamma-ray flux. Direct measurements of the cross section of both this reaction and the 18F(p,p)18F reaction have been performed between center of mass energies of 0.5 and 1.9 MeV. Simultaneous fits to both data sets with the R-Matrix formalism reveal several resonances, with the inferred parameters of populated states in 19Ne in general agreement with previous measurements. Of particular interest, extra strength has been observed above ECM \sim1.3 MeV in the 18F(p,p)18F reaction and between 1.3-1.7 MeV in the 18F(p,{\alpha})15O reaction. This is well described by a broad 1/2+ state, consistent with both a recent theoretical prediction and an inelastic scattering measurement. The astrophysical implications of a broad sub-threshold partner to this state are discussed.Comment: 7 pages, 4 figures, 2 table

Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells

Pyruvate kinase deficiency (PKD) is a rare erythroid metabolic disease caused by mutations in the PKLR gene. Erythrocytes from PKD patients show an energetic imbalance causing chronic non-spherocytic hemolytic anemia, as pyruvate kinase defects impair ATP production in erythrocytes. We generated PKD induced pluripotent stem cells (PKDiPSCs) from peripheral blood mononuclear cells (PB-MNCs) of PKD patients by non-integrative Sendai viral vectors. PKDiPSCs were gene edited to integrate a partial codon-optimized R-type pyruvate kinase cDNA in the second intron of the PKLR gene by TALEN-mediated homologous recombination (HR). Notably, we found allele specificity of HR led by the presence of a single-nucleotide polymorphism. High numbers of erythroid cells derived from gene-edited PKDiPSCs showed correction of the energetic imbalance, providing an approach to correct metabolic erythroid diseases and demonstrating the practicality of this approach to generate the large cell numbers required for comprehensive biochemical and metabolic erythroid analyses.info:eu-repo/semantics/publishedVersio

Survey and analysis of vegetation and hydrological change in English dune slack habitats

This report details work conducted under a Memorandum of Agreement (MoA) between Natural England and the Centre for Ecology and Hydrology and British Geological Survey, initiating a programme of linked vegetation and hydrological studies. As stated in the MoA, the overall aim of this collaboration is ‘To improve the conservation status of dune wetlands of European importance and the condition of the dune wetland features of sand dune SSSIs identified in Appendix 1, through a major improvement in understanding of dune ecohydrological functioning.’ In consultation with Natural England, nine sites were selected for survey of the dune wetland component in the summer of 2012, aiming to partially repeat the Sand Dune Survey of Great Britain (SDGB) in the late 1980s. The selected sites hold 77% of the English dune wetland resource. At each site, all dune wetlands were mapped, with the exception of the three sites on the Sefton Coast, where the majority of the core area was mapped but not satellite areas. For each site the geological setting, surface topography, surface water features, climatic setting and land cover were assessed and the most important hydrological processes identified

Fiscal developments and financial stress : a threshold VAR analysis

We use a threshold VAR analysis to study the linkages between changes in the debt ratio, economic activity and financial stress within different financial regimes. We use quarterly data for the US, the UK, Germany and Italy, for the period 1980:4– 2014:1, encompassing macro, fiscal and financial variables, and use nonlinear impulse responses allowing for endogenous regime-switches in response to structural shocks. The results show that output reacts mostly positively to an increase in the debt ratio in both financial stress regimes; however, the differences in estimated multipliers across regimes are relatively small. Furthermore, a financial stress shock has a negative effect on output and worsens the fiscal situation. The large time-variation and the estimated nonlinear impulse responses suggest that the size of the fiscal multipliers was higher than average in the 2008–2009 crisis.info:eu-repo/semantics/publishedVersio

Fiscal Multipliers and Public Debt Dynamics in Consolidations

The success of a consolidation in reducing the debt ratio depends crucially on the value of the multiplier, which measures the impact of consolidation on growth, and on the reaction of sovereign yields to such a consolidation. We present a theoretical framework that formalizes the re spo nse of the public debt ratio to fiscal consolidations in relation to the value of fiscal multipliers, the starting debt level and the cyclical elasticity of the budget balance. We also assess the role of markets confidence to fiscal consolidations under al ternative scenarios. We find that with high levels of public debt and sizeable fiscal multipliers , debt ratios are likely to increase in the short term in response to fiscal consolidations. Hence, the typical horizon for a consolidation during crises episo des to reduce the debt ratio is two - three years , although this horizon depends critically on the size and persistence of fiscal multipliers and the reaction of financial markets. Anyway, such undesired debt responses are mainly short - lived. This effect is very unlikely in non - crisis times, as it requires a number of conditions difficult to observe at the same time , especially high fiscal multipliers