5,897 research outputs found
Resolving Architectural Mismatches of COTS Through Architectural Reconciliation
The integration of COTS components into a system under development entails architectural mismatches. These have been tackled, so far, at the component level, through component adaptation techniques, but they also must be tackled at an architectural level of abstraction. In this paper we propose an approach for resolving architectural mismatches, with the aid of architectural reconciliation. The approach consists of designing and subsequently reconciling two architectural models, one that is forward-engineered from the requirements and another that is reverse-engineered from the COTS-based implementation. The final reconciled model is optimally adapted both to the requirements and to the actual COTS-based implementation. The contribution of this paper lies in the application of architectural reconciliation in the context of COTS-based software development. Architectural modeling is based upon the UML 2.0 standard, while the reconciliation is performed by transforming the two models, with the help of architectural design decisions.
Ground-based detection of a cloud of methanol from Enceladus: When is a biomarker not a biomarker?
Saturn's moon Enceladus has vents emerging from a sub-surface ocean, offering
unique probes into the liquid environment. These vents drain into the larger
neutral torus in orbit around Saturn. We present a methanol (CH3OH) detection
observed with IRAM 30-m from 2008 along the line-of-sight through Saturn's
E-ring. Additionally, we also present supporting observations from the Herschel
public archive of water (ortho-H2O; 1669.9 GHz) from 2012 at a similar
elongation and line-of-sight. The CH3OH 5(1,1)-4(1,1) transition was detected
at 5.9 sigma confidence. The line has 0.43 km/s width and is offset by +8.1
km/s in the moon's reference frame. Radiative transfer models allow for gas
cloud dimensions from 1750 km up to the telescope beam diameter ~73000 km.
Taking into account the CH3OH lifetime against solar photodissociation and the
redshifted line velocity, there are two possible explanations for the CH3OH
emission: methanol is primarily a secondary product of chemical interactions
within the neutral torus that (1) spreads outward throughout the E-ring or (2)
originates from a compact, confined gas cloud lagging Enceladus by several
km/s. We find either scenario to be consistent with significant redshifted H2O
emission (4 sigma) measured from the Herschel public archive. The measured
CH3OH:H2O abundance (> 0.5 per cent) significantly exceeds the observed
abundance in the direct vicinity of the vents (~0.01 per cent), suggesting
CH3OH is likely chemically processed within the gas cloud with methane (CH4) as
its parent species.Comment: 16 pages, 4 figures, accepted for publication in the International
Journal of Astrobiology (IJA
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Up and away: ontogenic transference as a pathway for aerial dispersal of microplastics
Microplastics (MPs) are ubiquitous pollutants found in marine, freshwater and terrestrial ecosystems. With so many MPs in aquatic systems it is inevitable that they will be ingested by aquatic organisms, and be transferred up through the food chain. However, to date, no study has considered whether MPs can be transmitted by means of ontogenic transference i.e. between life stages that utilise different habitats. Here, we determine whether fluorescent polystyrene beads could transfer between Culex mosquito life stages and, particularly, could move into the flying adult stage. We show for the first time that MPs can be transferred ontogenically from a feeding (larva) into a non-feeding (pupa) life stage and subsequently into the adult terrestrial life stage. However, transference is dependent on particle size, with smaller 2 ”m MPs transferring readily into pupae and adult stages, whilst 15 ”m MPs transferred at a significantly reduced rate. Microplastics appear to accumulate in the Malpighian tubule renal excretion system. The transfer of MPs to the adults represents a potential aerial pathway to contamination of new environments. Thus, any organism that feeds on terrestrial life phases of freshwater insects could be impacted by MPs found in aquatic ecosystems
Fracture toughness of the cancellous bone of FNF femoral heads in relation to its microarchitecture
This study considers the relationship between microarchitecture and mechanical properties for cancellous bone specimens collected from a cohort of patients who had suffered fractured necks of femur. OP
is an acute skeletal condition with huge socioeconomic impact [1] and it is associated with changes in both bone quantity and quality [2], which affect greatly the strength and toughness of the tissue [3].Support was provided by the EPSRC (EP/K020196: Point-ofCare High Accuracy Fracture Risk Prediction), the UK Department of Transport under the BOSCOS (Bone Scanning for Occupant Safety) project, and approved by Gloucester and Cheltenham NHS Trust hospitals under ethical consent (BOSCOS â Mr. Curwen CI REC ref 01/179G)
Chandra Observations of Extended X-ray Emission in Arp 220
We resolve the extended X-ray emission from the prototypical ultraluminous
infrared galaxy Arp 220. Extended, faint edge-brightened, soft X-ray lobes
outside the optical galaxy are observed to a distance of 10 to 15 kpc on each
side of the nuclear region. Bright plumes inside the optical isophotes coincide
with the optical line emission and extend 11 kpc from end to end across the
nucleus. The data for the plumes cannot be fit by a single temperature plasma,
and display a range of temperatures from 0.2 to 1 keV. The plumes emerge from
bright, diffuse circumnuclear emission in the inner 3 kpc centered on the
Halpha peak, which is displaced from the radio nuclei. There is a close
morphological correspondence between the Halpha and soft X-ray emission on all
spatial scales. We interpret the plumes as a starburst-driven superwind, and
discuss two interpretations of the emission from the lobes in the context of
simulations of the merger dynamics of Arp 220.Comment: Accepted for publication in ApJ; see also astro-ph/0208477 (Paper 1
Excitations in confined helium
We design models for helium in matrices like aerogel, Vycor or Geltech from a
manifestly microscopic point of view. For that purpose, we calculate the
dynamic structure function of 4He on Si substrates and between two Si walls as
a function of energy, momentum transfer, and the scattering angle. The
angle--averaged results are in good agreement with the neutron scattering data;
the remaining differences can be attributed to the simplified model used here
for the complex pore structure of the materials. A focus of the present work is
the detailed identification of coexisting layer modes and bulk--like
excitations, and, in the case of thick films, ripplon excitations. Involving
essentially two--dimensional motion of atoms, the layer modes are sensitive to
the scattering angle.Comment: Phys. Rev. B (2003, in press
Identification of new reference genes for the normalisation of canine osteoarthritic joint tissue transcripts from microarray data
<p>Abstract</p> <p>Background</p> <p>Real-time reverse transcriptase quantitative polymerase chain reaction (real-time RT-qPCR) is the most accurate measure of gene expression in biological systems. The comparison of different samples requires the transformation of data through a process called normalisation. Reference or housekeeping genes are candidate genes which are selected on the basis of constitutive expression across samples, and allow the quantification of changes in gene expression. At present, no reference gene has been identified for any organism which is universally optimal for use across different tissue types or disease situations. We used microarray data to identify new reference genes generated from total RNA isolated from normal and osteoarthritic canine articular tissues (bone, ligament, cartilage, synovium and fat). RT-qPCR assays were designed and applied to each different articular tissue. Reference gene expression stability and ranking was compared using three different mathematical algorithms.</p> <p>Results</p> <p>Twelve new potential reference genes were identified from microarray data. One gene (mitochondrial ribosomal protein S7 [<it>MRPS7</it>]) was stably expressed in all five of the articular tissues evaluated. One gene HIRA interacting protein 5 isoform 2 [<it>HIRP5</it>]) was stably expressed in four of the tissues evaluated. A commonly used reference gene glyceraldehyde-3-phosphate dehydrogenase (<it>GAPDH</it>) was not stably expressed in any of the tissues evaluated. Most consistent agreement between rank ordering of reference genes was observed between <it>Bestkeeper©</it> and geNorm, although each method tended to agree on the identity of the most stably expressed genes and the least stably expressed genes for each tissue. New reference genes identified using microarray data normalised in a conventional manner were more stable than those identified by microarray data normalised by using a real-time RT-qPCR methodology.</p> <p>Conclusion</p> <p>Microarray data normalised by a conventional manner can be filtered using a simple stepwise procedure to identify new reference genes, some of which will demonstrate good measures of stability. Mitochondrial ribosomal protein S7 is a new reference gene worthy of investigation in other canine tissues and diseases. Different methods of reference gene stability assessment will generally agree on the most and least stably expressed genes, when co-regulation is not present.</p
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