Picosecond fluctuating protein energy landscape mapped by pressure–temperature molecular dynamics simulation

Microscopic statistical pressure fluctuations can, in principle, lead to corresponding fluctuations in the shape of a protein energy landscape. To examine this, nanosecond molecular dynamics simulations of lysozyme are performed covering a range of temperatures and pressures. The well known dynamical transition with temperature is found to be pressure-independent, indicating that the effective energy barriers separating conformational substates are not significantly influenced by pressure. In contrast, vibrations within substates stiffen with pressure, due to increased curvature of the local harmonic potential in which the atoms vibrate. The application of pressure is also shown to selectively increase the damping of the anharmonic, low-frequency collective modes in the protein, leaving the more local modes relatively unaffected. The critical damping frequency, i.e., the frequency at which energy is most efficiently dissipated, increases linearly with pressure. The results suggest that an invariant description of protein energy landscapes should be subsumed by a fluctuating picture and that this may have repercussions in, for example, mechanisms of energy dissipation accompanying functional, structural, and chemical relaxation

Palaeotethys-related sediments of the Karaburun Peninsula, western Turkey: constraints on provenance and stratigraphy from detrital zircon geochronology

Detrital zircon U–Pb geochronology of 15 Late Palaeozoic to Early Mesozoic siliciclastic sandstones from the Karaburun Peninsula in western Turkey determines maximum sedimentation ages, identifies possible source areas, and anchors the study area within the Palaeotethyan realm. Siliciclastic sandstones yielded ages from Triassic to Archean with major input from Palaeozoic to Neoproterozoic sources and very few Mesoproterozoic zircons. The youngest age groups set the new limit of the maximum depositional ages to Late Carboniferous–Early Permian for the Küçükbahçe and Dikendağı formations. Detrital zircons from Triassic sandstones are mainly Neoproterozoic and Palaeozoic in age. Zircons from the Scythian–Anisian Gerence Formation are predominantly Devonian and Carboniferous in age, while also Permian and Triassic zircon grains occur in the Carnian–Rhaetian Güvercinlik Formation. According to the zircon age populations and the data available from possible source regions, the Karaburun siliciclastic sediments, with the exception of two samples from the Dikendağı Formation, record sediment supply from units located at the southern margin of Eurasia during Late Palaeozoic and Early Mesozoic times. This interpretation is in agreement with palaeotectonic reconstructions for the closely related Greek islands of Chios and Inousses. The presence of Devonian accompanied by Carboniferous zircons in some of the Karaburun samples reveals similarities with Karakaya Complex sandstones of the Sakarya Zone in NW Turkey

Modeling of electrons and photons beams of linear (planar) accelerator Elekta Synergy in modelling system PLUNC

The article presents the experience of creating a model of beam in the non-commercial 3D Plan-UNC radiation treatment planning system (PLUNC). The results of dosimetry for electron and photon beams of the Elekta Synergy linear accelerator are presented

Evolution of the Palaeotethys in the Eastern Mediterranean: A multi-method approach to unravel the age, provenance and tectonic setting of the Upper Palaeozoic Konya Complex and its Mesozoic cover sequence (south-central Turkey)

Thirteen siliciclastic sediments from the Upper Palaeozoic Konya Complex and its Mesozoic cover were studied by a multi-method approach combining thin-section petrography, bulk-rock geochemistry, mineral chemistry of rutile, and U–Pb geochronology of detrital zircons. Provenance sensitive data of samples from the Upper Palaeozoic Halıcı Formation indicate sediment supply from mainly low- to medium-grade metamorphosed sedimentary rocks of felsic character, while contribution from volcanic rocks was rare. The detrital zircon record of sediments from the Halıcı Formation documents sediment supply from different sources and excludes a similar provenance. Some samples show great similarities with Palaeozoic sandstones from the cover sequence of the Saharan Metacraton and the Arabian–Nubian Shield, while the other samples indicate a provenance that must be sought in units with a southern Eurasian affinity. The upper limit for sediment deposition in the Halıcı Formation is mostly constrained by Early Palaeozoic zircon populations, however, sediment accumulation in Pennsylvanian–Cisuralian time is more likely, contemporaneously with the Upper Palaeozoic succession on the Karaburun Peninsula (western Turkey). The provenance of sediments from the Upper Triassic Ardıçlı Formation remains enigmatic, but the source should be sought nonetheless in units close to the depositional site. In any case, detrital zircon age spectra and compositional data exclude recycling of underlying rock units (i.e. Halıcı Formation). Overall, our new provenance data reveal great similarities between the Konya Complex and comparable units (Chios, Karaburun) but also highlight distinct differences in terms of sediment composition and provenance

Technology Evaluation for Environmental Risk Mitigation Compendium

The Technology Evaluation for Environmental Risk Mitigation (TEERM) Principal Center and its predecessor organization the Acquisition Pollution Prevention Program (AP2) supported the National Aeronautics and Space Administration (NASA) in identifying technology solutions to risks and costs to NASA programs driven by environmental regulations and requirements. TEERM researched the commercial and government marketplace to locate viable and available technologies that met NASAs needs. TEERM focused on addressing environmentally-driven risks of direct concern to NASA programs and facilities, including hazardous materials in NASA operations and materials that became obsolescent because of environmental regulations. TEERM projects aimed to reduce cost; ensure the health and safety of people, assets, and the environment; promote efficiency; and minimize duplication. Major TEERM and AP2 projects focused on waste minimization and hazardous waste treatment, recycling, corrosion prevention and control, solvent and ozone depleting substances substitution, and aqueous based cleaners. In 2017, NASA made the decision to terminate the TEERM Principal Center. This Compendium Report documents TEERM and AP2 project successes. The Compendium Report traces the evolution of TEERM based on evolving risks and requirements for NASA and its relationship to the Space Shuttle Program, the United States Department of Defense, the European Space Agency, and other public and private stakeholders. This Compendium Report also documents project details from Project Summaries and Joint Test Plans and describes project stakeholders and collaborative effort results

A Spin Modulated Telescope to Make Two Dimensional CMB Maps

We describe the HEMT Advanced Cosmic Microwave Explorer (HACME), a balloon borne experiment designed to measure sub-degree scale Cosmic Microwave Background anisotropy over hundreds of square degrees, using a unique two dimensional scanning strategy. A spinning flat mirror that is canted relative to its spin axis modulates the direction of beam response in a nearly elliptical path on the sky. The experiment was successfully flown in February of 1996, achieving near laboratory performance for several hours at float altitude. A map free of instrumental systematic effects is produced for a 3.5 hour observation of 630 square degrees, resulting in a flat band power upper limit of (l(l+1)C_l/2 pi)^0.5 < 77 microK at l = 38 (95% confidence). The experiment design, flight operations and data, including atmospheric effects and noise performance, are discussed.Comment: 4 pages, 3 figure