Redescription of Caprella hirsuta Mayec 1890 (Crustacea, Amphipoda, Caprellidea) from the Strait of Gibraltar

Caprella hirsuta Mayer, 1890 is redescribed based on specimens collected from the Strait of Gibraltar (Southern Spain-Northern Africa) during a study of the amphipod fauna from these coasts. Careful examination of these caprellids revealed differences with the previous descriptions, mainly the structure of gnathopod 2, pereopods and abdomen. Key words: Crustacea, Amphipoda, Caprellidea, Caprella hirsuta, Strait of Gibraltar, Redescription.Caprella hirsuta Mayer, 1890 is redescribed based on specimens collected from the Strait of Gibraltar (Southern Spain-Northern Africa) during a study of the amphipod fauna from these coasts. Careful examination of these caprellids revealed differences with the previous descriptions, mainly the structure of gnathopod 2, pereopods and abdomen. Key words: Crustacea, Amphipoda, Caprellidea, Caprella hirsuta, Strait of Gibraltar, Redescription.Caprella hirsuta Mayer, 1890 is redescribed based on specimens collected from the Strait of Gibraltar (Southern Spain-Northern Africa) during a study of the amphipod fauna from these coasts. Careful examination of these caprellids revealed differences with the previous descriptions, mainly the structure of gnathopod 2, pereopods and abdomen. Key words: Crustacea, Amphipoda, Caprellidea, Caprella hirsuta, Strait of Gibraltar, Redescription

Cambios ontogenéticos e intraespecíficos observados en la rádula de Polycera aurantiomarginata García and Bobo, 1984 (Gastropoda Opisthobranchia)

Polycera aurantiomarginata García and Bobo 1984 has a stable population in the intertidal area of El Portil beach (Huelva, SW Spain). This fact allowed specimens of different sizes to be collected from March 2001 to December 2003. In this paper, the ontogenetic variations of the radula of P. aurantiomarginata are studied. The radulae of 141 specimens were examined, 138 from El Portil and 3 from La Herradura (Granada, SE Spain). Specimens of 1.5-2 mm in length lack the typical radula described for P. aurantiomarginata. They have the so called pre-radula whose teeth are different in size and shape from the typical radula of the adults. In the specimens of 3 and 4 mm the pre-radula coexists with the characteristic radula, which is the single structure present in the specimens larger than 4 mm. The following features of the radula are included in this study: radular length, number of teeth rows and length of the outer lateral teeth. According to the three measured variables, the affinities among specimens without a pre-radula were established through cluster analysis, which defined three different groups (4-10 mm, 11-22 mm and 23-48 mm). Correlations between specimen length and radula length, number of rows and mean length of outer lateral teeth were significant. Feeding strategies could be related to the different morphology of the radula established by the Cluster analysis.Polycera aurantiomarginata García y Bobo, 1984 muestra una población estable y en la localidad de El Portil (Huelva, SW de España), lo que ha permitido la recolección, desde marzo de 2001 hasta diciembre de 2003, de un alto número de ejemplares de todos los tamaños. En el presente estudio se ha extraído la rádula de 141 animales, 138 recogidos en la zona intermareal de El Portil y 3 en La Herradura (Granada). Los tamaños de los animales han oscilado entre 1.5 mm y 48 mm. Se ha podido observar en los individuos de entre 1.5 y 2 mm la existencia de una pre-rádula cuyos dientes son morfológicamente diferentes a los de la rádula de los individuos mayores; sin embargo, en los ejemplares de 3 y 4 mm esta pre-rádula coexiste con la rádula típica, siendo esta estructura la única presente en individuos de longitud igual o mayor a 4 mm. A cada una de las rádulas extraídas, tanto con pre-rádula o sin ella, se le ha medido la longitud total de la cinta, la longitud del diente lateral externo y el número de filas de dientes. Considerando los tres parámetros medidos, las afinidades entre los ejemplares sin pre-rádula se establecieron a partir de análisis de Cluster, que definieron tres grupos distintos (4-10 mm, 11-22 mm y 23-48 mm). Las correlaciones existentes entre la longitud de los individuos y la longitud de la rádula, el número de filas y la longitud media de los dientes fueron significativas. Las diferencias morfológicas reconocidas en los grupos considerados podrían estar relacionadas con distintas estrategias alimentarias.

Approach to the Lower Pliocene marine-continental correlation from southern Spain. The micrommamal site of Alhaurín el Grande-1 (Málaga Basin, Betic Cordillera, Spain)

A new micromammal site at Alhaurín el Grande (Málaga, southern Spain) located above early Pliocene marine deposits allows an approach to the marine-continental correlation for this age. The early Pliocene marine filling throughout the Málaga Basin is developed in three transgressive-regressive sequences (Pl-1, Pl-2, and Pl-3 units) bounded by discontinuities. At the top of the intermediate sequence Pl-2, peaty sediments have yielded fossils of Rodentia, Lagomorpha, Insectivora, and Crocodylia. The presence of Cricetus barrieri Mein & Michaux, 1970 in combination with murids, both of primitive morphology, such as Apodemus gudrunae Van de Weerd, 1976, and more advanced forms (i.e. Occitanomys brailloni Michaux, 1969 and Stephanomys donnezani cordii Ruiz Bustos, 1986), points to an early Ruscinian age (MN 14 biozone). Based on the planktonic foraminifers, the biostratigraphic data indicate that marine sediments just below the micromammal beds belong to the MPl-2 biozone of the early Zanclean. Available paleomagnetic data from the marine sediments show that the micromammal bed must be located between the normal geomagnetic subchron C3n3n (4.89-4.80 Ma) and the subchron C3n2n (4.63-4.49 Ma), limiting the age of this site to the late part of the early Zanclean

Speckle reduction in double-pass retinal images using variable-focus lenses

Speckle arises in double-pass images when coherent light is scattered by the retina. Since this noise degrades the images that are used to characterize the eye, there is special attention in reducing speckle when working with instruments based on retina reflections. In this work, we present a method for speckle reduction in double-pass retinal images by producing minor periodic variations in the vergence of the beam entering the eye with a variable-focus lens during image recording. Measurements in an artificial and a real eye following the implementation of the method corroborate the speckle reduction

Caprellids (Crustacea: Amphipoda: Caprellidae) from shallow waters of the Caribbean coast of Venezuela

AbstractThe caprellidean fauna of Venezuela is investigated. Twenty-seven stations in shallow waters of the states Falcón, Carabobo, Aragua, Anzoátegui, Sucre and Nueva Esparta were sampled, and the caprellids were sorted and identified. A total of 3984 specimens were identified; 12 species in eight genera are reported. Two species, Caprella penantis Leach, 1814 and Paracaprella digitimanus Quitete, 1971, are new records for Venezuelan waters. The electronic supplement to this paper includes illustrations and a key to all caprellid species known from Venezuela, as well as comments on their distribution and ecology

Submarine cartographic methodology for managing and conserving littoral areas: Mapping the benthic communities of the northern coast of the Straits of Gibraltar

The cartography of benthic communities is, today, essential to promoting adequate strategies for the use, management and conservation of littoral areas, especially if they are large protected zones. In each zone, cartography is necessary to elaborate a management zoning map, depending on the ecological value of the different benthic communities established and on the local geographical distribution. The methodology used in the elaboration of a map including the benthic communities of the Straits of Gibraltar (0-30 m depth; 40 km of littoral extension), in spite of the complexity of these kinds of objectives, represents an approach to the cartography of the submarine sessile biota of large littoral zones of protected areas. The present study combines physical data (bathymetry and type of substrate), collected using acoustic techniques, and biological data (benthic communities), collected during an intensive sampling programme using scuba (hard bottom: image analysis) and dredging (soft bottom: granulometry and benthic fauna). The information has been geoindexed to be inserted, as different layers, into a Geographic Information System (GIS).La cartografía de las comunidades bentónicas es esencial, actualmente, para promover actuaciones eficientes de uso, gestión y conservación de las zonas litorales, especialmente en el ámbito de grandes espacios litorales protegidos. En cada uno de éstos, la cartografía resulta determinante para la elaboración de un mapa de zonificación de usos, condicionado, en gran medida, por los distintos valores ecológicos que puedan asignarse a las diferentes comunidades bentónicas establecidas y a sus distribuciones geográficas locales. La metodología utilizada en la elaboración del mapa de las comunidades bentónicas del estrecho de Gibraltar (en el intervalo batimétrico 0-30 m y de 40 km de extensión litoral aproximada), dada la complejidad que reviste este tipo de objetivos, supone una aproximación a la cartografía de la biota sésil sumergida, en tramos litorales amplios contenidos en áreas protegidas. Se han combinado, mediante superposición de información, datos físicos de batimetría y tipos de fondo, obtenidos mediante técnicas acústicas y convenientemente cartografiados, con datos biológicos de las comunidades bentónicas, obtenidos en campaña intensiva de buceo científico (con la toma de imágenes en sustrato duro, para su ulterior análisis) y mediante dragado (con registros de granulometría y fauna endobentónica en sustrato blando). La información ha sido georreferenciada adecuadamente para su introducción, como capas independientes, en un sistema de información geográfica (SIG).Instituto Español de Oceanografí

Tissue response to dental implants with platform switching

La evolución en los diseños de los sistemas de implantes y en la configuración de los pilares protési- cos ha desarrollado el concepto de plataforma reducida que comprende la colocación de un pilar más estrecho que la plataforma del implante para aumentar su distancia de la interfase hueso-implante. La plataforma reducida es considerada un factor importante para preservar la estabilidad del hueso crestal y de los tejidos blandos y asegurar el éxito de los implantes dentales a largo plazo. La plataforma redu- cida reduce las fuerzas oclusales y la contaminación bacteriana en la interfase entre el hueso crestal y el implante. Los estudios experimentales en animales y clínicos en pacientes muestran su eficacia para prevenir la pérdida ósea y de los tejidos blandos periimplantarios Conclusiones. La introducción de la plataforma reducida constituye un importante campo en la investi- gación experimental en implantología oral y en el tratamiento clínico con implantes para mantener los tejidos periimplantarios.The evolution of designs of implant systems and abutments configurations has developed the concept of platform-switching that involves the connection of a narrower abutment to the platform implant to allow horizontal distance of the interface bone-implant. Platform-switching is considered an important factor to preserve the stability of crestal bone and soft tissue ensuring the success of dental implants in the long-term follow-up. Platform-switching reduces the forces of occlusal loading and bacterial conta- mination in the interface between the crestal bone and the implant. Experimental studies in animals and clinical studies in patients showed that implants with platform-switching have demonstrated the effecti- veness to prevent peri-implant bone loss and subsequent soft tissue loss. Conclusions. The platform-switching constitute an important field for research of experimental implant dentistry and clinical implant treatment in the maintenance of peri-implant tissue

Olaparib in combination with pegylated liposomal doxorubicin for platinum-resistant ovarian cancer regardless of BRCA status: a GEICO phase II trial (ROLANDO study)

Inhibidor de PARP; Olaparib; Càncer d'ovari recurrent resistent al platíInhibidor de PARP; Olaparib; Cáncer de ovario recurrente resistente al platinoPARP inhibitor; Olaparib; Platinum-resistant recurrent ovarian cancerBackground There is limited evidence for the benefit of olaparib in platinum-resistant ovarian cancer (PROC) patients with BRCA wild-type tumors. This study investigated whether this combination of a DNA-damaging chemotherapy plus olaparib is effective in PROC regardless BRCA status. Patients and methods Patients with high-grade serous or endometrioid ovarian carcinoma and one previous PROC recurrence were enrolled regardless of BRCA status. Patients with ≤4 previous lines (up to 5 in BRCA-mut) with at least one previous platinum-sensitive relapse were included; primary PROC was allowed only in case of BRCA-mut. Patients initially received six cycles of olaparib 300 mg b.i.d. (biduum) + intravenous pegylated liposomal doxorubicin (PLD) 40 mg/m2 (PLD40) every 28 days, followed by maintenance with olaparib 300 mg b.i.d. until progression or toxicity. The PLD dose was reduced to 30 mg/m2 (PLD30) due to toxicity. The primary endpoint was progression-free survival (PFS) at 6 months (6m-PFS) by RECIST version 1.1. A proportion of 40% 6m-PFS or more was considered of clinical interest. Results From 2017 to 2020, 31 PROC patients were included. BRCA mutations were present in 16%. The median of previous lines was 2 (range 1-5). The overall disease control rate was 77% (partial response rate of 29% and stable disease rate of 48%). After a median follow-up of 10 months, the 6m-PFS and median PFS were 47% and 5.8 months, respectively. Grade ≥3 treatment-related adverse events occurred in 74% of patients, with neutropenia/anemia being the most frequent. With PLD30 serious AEs were less frequent than with PLD40 (21% versus 47%, respectively); moreover, PLD30 was associated with less PLD delays (32% versus 38%) and reductions (16% versus 22%). Conclusions The PLD–olaparib combination has shown significant activity in PROC regardless of BRCA status. PLD at 30 mg/m2 is better tolerated in the combination.This work was supported by Grupo Español de Investigación en Cáncer de Ovario (GEICO) (no grant number). AstraZeneca provided olaparib and awarded a grant to GEICO (no grant number) to pay the costs of the study but did not take part in the conduct of the current clinical trial or in the analysis and interpretation of the results. Pegylated ribosomal doxorubicin was provided by the sites according to local standard procedures

Complex regional pain syndrome (CRPS), a review

Complex regional pain syndrome is a chronic and painful condition that affects the quality of life of patients. It is usually triggered by a traumatic event of the soft tissues involving the nervous tissue. Although the factors that cause the syndrome are varied and not well known, different etiopathologic concepts have been proposed to explain the presence of this syndrome, such as autonomic dysfunction and changes in CNS plasticity, among others. The patient characteristically presents pain, sensory abnormalities, vasomotor disturbances in the skin, edema, changes in sweating, and motor alterations. The pain is associated with changes in the autonomic nervous system and has a distal predominance. Since there is no definitive diagnostic test, diagnosis is mainly based on a complete medical history and physical examination. Treatment is multidisciplinary and based on pain relief. Although in most cases evolution is favorable, rapid diagnosis and treatment are recommended to avoid dystrophic stage as much as possibl