17 research outputs found
Sarcomas primarios de hueso: estudio por citometría estática mediante análisis digital de imagen
Se presenta un estudio morfométrico y densitométrico mediante análisis digital
de imagen de una serie de 50 tumores óseos malignos (32 osteosarcomas, 12 condrosarcomas
y 6 histiocitomas fibrosos malignos de hueso), con el fin de evaluar la utilidad
de la técnica para establecer el grado y el pronóstico de estas neoplasias. Las variables
morfométricas y la disposición de la cromatina guardan una estrecha relación con el grado
histológico (Spearman; p < 0,05) y muestran diferencias estadísticamente significativas
entre los tumores considerados de alto y bajo grado en base a su presentación y evolución
clínica. La ploidía estimada por densitometría óptica se comporta como un factor pronóstico
independiente en el análisis multivariante de la serie de tumores de alto grado (COX;
p < 0,001). La citometría estática, aunque más lenta e imprecisa que la citometría de flujo
en la determinación de los picos de ploidía, permite analizar el modelo de cromatina y
contribuye objetivamente al establecimiento del grado biológico de los tumores óseos.A densitometry and morphometric assessment by static image cytometry of
50 malignant bone tumors (32 osteosarcomas, 12 chondrosarcomas, and 6 malignant fibrous
histiocytomas of bone) was performed in order to assess the validity of the technic
in the pathobiological and prognostic evaluation of these neoplasms. A strong correlation
between the morphometric features, cromatine distribution and histologic grade was
found (Spearman; p < 0.05). These parameters are also statistically different for hight and
low grade tumors in clinical staging. The stimation of DNA ploidy by optic densitometry
is a significant prognostic factor in the multivariant analysis for the high grade tumors
(COX; p < 0.001). Although Flow cytometry is a better procedure to evaluate DNA ploidy
peaks, our study reveals static image cytometry as a useful technic for determine the
cromatine model and objective assessment of the biological grade of bone neoplasms
RICORS2040 : The need for collaborative research in chronic kidney disease
Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true
Desarrollo de página web multimedia interactiva para apoyo docente en materias del área Química-Física
Realización proyecto: Departamento de Química y Física. Universidad de Salamanca. Lugar trabajo principal: Faculta de Farmacía. Objetivo: Diseñar y desarrollar una página web, elaborar contenidos de apoyo docente. Materiales elaborados: memoria, CD-ROM para demostracción, programa HTML de página web. Materiales utilizados: Ordenador PC y periférico, editor HTML: Frontpage de Microsoft. El documento no está publicado.Junta de Castilla y León. Dirección General de Universidades e Investigación. Monasterio Ntra. Sra. del Prado. Autovia Puente Colgante s/n. 47071 Valladolid. Teléfono: 983-41.18.87Castilla y LeónES