Analisis Program Pembangunan dan Pemberdayaan Kewilayahan di Kota Bandung

Perbedaan hasil penyerapan anggaran PIPPK Di Kelurahan Cihapit dan Kelurahan Merdeka dapat dijadikan dasar berjalan dengan baiknya suatu program.Terjadinya perbedaan perbedaan penyerapan anggaran antara dua kelurahan antara kelurahan merdeka dan cihapit menjadi fondasi penulis melakukan analis akan inovasi program yang sedang berjalan saat ini, yaitu program PIPPK di kota Bandung. Metode penelitian menggunakan pendekatan kualitatif dan data diperoleh dengan studi kepustakaan dan studi lapangan. Hasil penelitian menunjukkan salah satu penyebab perbedaan penyerapan anggaran antara dua kelurahan tersebut terdapat pada kegiatan dan program yang dilakukan oleh kelurahan dan dukungan yang optimal dari pihak Aparatur dan Masyarakat, sehingga menghasilkan kelurahan Cihapit dengan dukungan aparatur dan desa dapat mengoptimalkan dana dari program PIPPK beda dengan kelurahan Merdeka di mana yaitu kurangnya partisipasi masyarakat dan juga masih kurangnya aparatur di kelurahan merdeka membuat sosialisasi kepada masyarakat menjadi kurang. mengemukakan saran Pemerintah Kota Bandung Perlu peninjauan ulang mengenai tambahan SDM ahli sebagai tenaga pendamping di Kelurahan khusus untuk menangani PIPPK agar hasilnya lebih maksimal mengingat dengan adanya PIPPK tentunya memberikan tambahan beban kerja bagi SDM yang ada di Kelurahan yang jumlah personil nya hanya 7 sampai 8 orang

Non supersymmetric strong coupling background from the large N quantum mechanics of two matrices coupled via a Yang-Mills interaction

We derive the planar large N non-supersymmetric background of the quantum mechanical hamiltonian of two hermitean matrices coupled via a Yang-Mills interaction, in terms of the density of eigenvalues of one of the matrices. This background satisfies an implicit non linear integral equation, with a perturbative small coupling expansion and a solvable large coupling solution, which is obtained. The energy of system and the expectation value of several correlators are obtained in this strong coupling limit. They are free of infrared divergences.Comment: Latex, 13 page

Magic angle spinning (MAS) NMR: a new tool to study the spatial and electronic structure of photosynthetic complexes

In the last two decades, Magic Angle Spinning (MAS) NMR has created its own niche in studies involving photosynthetic membrane protein complexes, owing to its ability to provide structural and functional information at atomic resolution of membrane proteins when in the membrane, in the natural environment. The light-harvesting two (LH2) transmembrane complex from Rhodopseudomonas acidophila is used to illustrate the procedure of the technique applicable in photosynthesis research. One- and two-dimensional solid-state NMR experiments involving 13C- and 15N-labeled LH2 complexes allow to make a sequence-specific assignment of NMR signals, which forms the basis for resolving structural details and the assessment of charge transfer, electronic delocalization effects, and functional strain in the ground state

HR-MAS NMR Applications in Plant Metabolomics

Metabolomics is used to reduce the complexity of plants and to understand the underlying pathways of the plant phenotype. The metabolic profile of plants can be obtained by mass spectrometry or liquid-state NMR. The extraction of metabolites from the sample is necessary for both techniques to obtain the metabolic profile. This extraction step can be eliminated by making use of high-resolution magic angle spinning (HR-MAS) NMR. In this review, an HR-MAS NMR-based workflow is described in more detail, including used pulse sequences in metabolomics. The pre-processing steps of one-dimensional HR-MAS NMR spectra are presented, including spectral alignment, baseline correction, bucketing, normalisation and scaling procedures. We also highlight some of the models which can be used to perform multivariate analysis on the HR-MAS NMR spectra. Finally, applications of HR-MAS NMR in plant metabolomics are described and show that HR-MAS NMR is a powerful tool for plant metabolomics studies

Decreased dopamine activity predicts relapse in methamphetamine abusers.

Studies in methamphetamine (METH) abusers showed that the decreases in brain dopamine (DA) function might recover with protracted detoxification. However, the extent to which striatal DA function in METH predicts recovery has not been evaluated. Here we assessed whether striatal DA activity in METH abusers is associated with clinical outcomes. Brain DA D2 receptor (D2R) availability was measured with positron emission tomography and [(11)C]raclopride in 16 METH abusers, both after placebo and after challenge with 60 mg oral methylphenidate (MPH) (to measure DA release) to assess whether it predicted clinical outcomes. For this purpose, METH abusers were tested within 6 months of last METH use and then followed up for 9 months of abstinence. In parallel, 15 healthy controls were tested. METH abusers had lower D2R availability in caudate than in controls. Both METH abusers and controls showed decreased striatal D2R availability after MPH and these decreases were smaller in METH than in controls in left putamen. The six METH abusers who relapsed during the follow-up period had lower D2R availability in dorsal striatum than in controls, and had no D2R changes after MPH challenge. The 10 METH abusers who completed detoxification did not differ from controls neither in striatal D2R availability nor in MPH-induced striatal DA changes. These results provide preliminary evidence that low striatal DA function in METH abusers is associated with a greater likelihood of relapse during treatment. Detection of the extent of DA dysfunction may be helpful in predicting therapeutic outcomes

Gene frequencies of ABO and rhesus blood groups in Sabians (Mandaeans), Iraq

The present study aimed to determine the frequency of ABO and Rh blood group antigens among Sabians (Mandaeans) population. This paper document the frequency of ABO and Rh blood groups among the Sabians (Mandaeans) population of Iraq.There is no data available on the ABO/Rh (D) frequencies in the Sabians (Mandaeans) population. Total 341 samples analyzed; phenotype O blood type has the highest frequency 49.9%, followed by A 28.7%, and B 13.8% whereas the lowest prevalent blood group was AB 7.6%. The overall phenotypic frequencies of ABO blood groups were O>A>B>AB. The allelic frequencies of O, A, and B alleles were 0.687, 0.2 and 0.1122 respectively. Rhesus study showed that with a percentage of 96.2% Rh (D) positive is by far the most prevalent, while Rh (d) negative is present only in 3.8% of the total population. The Sabians (Mandaeans) ethnic group showed the same distribution of ABO and Rh blood groups with others ethnic groups in Iraqi population

Comprehensive Determination of Protein Tyrosine pK(a) Values for Photoactive Yellow Protein Using Indirect C-13 NMR Spectroscopy

Upon blue-light irradiation, the bacterium Halorhodospira halophila is able to modulate the activity of its flagellar motor and thereby evade potentially harmful UV radiation. The 14 kDa soluble cytosolic photoactive yellow protein (PYP) is believed to be the primary mediator of this photophobic response, and yields a UV/Vis absorption spectrum that closely matches the bacterium's motility spectrum. In the electronic ground state, the para-coumaric acid (pCA) chromophore of PYP is negatively charged and forms two short hydrogen bonds to the side chains of Glu-46 and Tyr-42. The resulting acid triad is central to the marked pH dependence of the optical-absorption relaxation kinetics of PYP. Here, we describe an NMR approach to sequence-specifically follow all tyrosine side-chain protonation states in PYP from pH 3.41 to 11.24. The indirect observation of the nonprotonated (13)C(γ) resonances in sensitive and well-resolved two-dimensional (13)C-(1)H spectra proved to be pivotal in this effort, as observation of other ring-system resonances was hampered by spectral congestion and line-broadening due to ring flips. We observe three classes of tyrosine residues in PYP that exhibit very different pK(a) values depending on whether the phenolic side chain is solvent-exposed, buried, or hydrogen-bonded. In particular, our data show that Tyr-42 remains fully protonated in the pH range of 3.41–11.24, and that pH-induced changes observed in the photocycle kinetics of PYP cannot be caused by changes in the charge state of Tyr-42. It is therefore very unlikely that the pCA chromophore undergoes changes in its electrostatic interactions in the electronic ground state

The design space of a configurable autocompletion component

Autocompletion is a commonly used interface feature in diverse applications. Semantic Web data has, on the one hand, the potential to provide new functionality by exploiting the semantics in the data used for generating autocompletion suggestions. Semantic Web applications, on the other hand, typically pose extra requirements on the semantic properties of the suggestions given. When the number of syntactic matches becomes too large, some means of selecting a semantically meaningful subset of suggestions to be presented to the user is needed. In this paper we identify a number of key design dimensions of autocompletion interface components. Our hypothesis is that a one-size-fits-all solution to autocompletion interface components does not exist, because different tasks and different data sets require interfaces corresponding to different points in our design space. We present a fully configurable architecture, which can be used to configure autocompletion components to the desired point in this design space. The architecture has been implemented as an open source software component that can be plugged into a variety of applications. We report on the results of a user evaluation that confirms this hypothesis, and describe the need to evaluate semantic autocompletion in a task and application-specific context

The design space of a configurable autocompletion component

Autocompletion is a commonly used interface feature in diverse applications. Semantic Web data has, on the one hand, the potential to provide new functionality by exploiting the semantics in the data used for generating autocompletion suggestions. Semantic Web applications, on the other hand, typically pose extra requirements on the semantic properties of the suggestions given. When the number of syntactic matches becomes too large, some means of selecting a semantically meaningful subset of suggestions to be presented to the user is needed. In this paper we identify a number of key design dimensions of autocompletion interface components. Our hypothesis is that a one-size-fits-all solution to autocompletion interface components does not exist, because different tasks and different data sets require interfaces corresponding to different points in our design space. We present a fully configurable architecture, which can be used to configure autocompletion components to the desired point in this design space. The architecture has been implemented as an open source software component that can be plugged into a variety of applications. We report on the results of a user evaluation that confirms this hypothesis, and describe the need to evaluate semantic autocompletion in a task and application-specific context

Active-Site pKa Determination for Photoactive Yellow Protein Rationalizes Slow Ground-State Recovery

The ability to avoid blue-light radiation is crucial for bacteria to survive. In Halorhodospira halophila, the putative receptor for this response is known as photoactive yellow protein (PYP). Its response to blue light is mediated by changes in the optical properties of the chromophore para-coumaric acid (pCA) in the protein active site. PYP displays photocycle kinetics with a strong pH dependence for ground-state recovery, which has remained enigmatic. To resolve this problem, a comprehensive pK(a) determination of the active-site residues of PYP is required. Herein, we show that Glu-46 stays protonated from pH 3.4 to pH 11.4 in the ground (pG) state. This conclusion is supported by the observed hydrogen-bonded protons between Glu-46 and pCA and Tyr-42 and pCA, which are persistent over the entire pH range. Our experimental results show that none of the active-site residues of PYP undergo pH-induced changes in the pG state. Ineluctably, the pH dependence of pG recovery is linked to conformational change that is dependent upon the population of the relevant protonation state of Glu-46 and the pCA chromophore in the excited state, collaterally explaining why pG recovery is slow