1,508 research outputs found

    Show, Prefer and Tell: Incorporating User Preferences into Image Captioning

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    Image Captioning (IC) is the task of generating natural language descriptions for images. Models encode the image using a convolutional neural network (CNN) and generate the caption via a recurrent model or a multi-modal transformer. Success is measured by the similarity between generated captions and human-written “ground-truth” captions, using the CIDEr [14], SPICE [1] and METEOR [2] metrics. While incremental gains have been made on these metrics, there is a lack of focus on end-user opinions on the amount of content in captions. Studies with blind and low-vision participants have found that lack of detail is a problem [6, 13, 17], and that the preferred amount of content varies between individuals [13], as do individual opinions on the trade-off between correctness and adding additional content with lower confidence [9]. We propose a more user-centered approach with an adjustable amount of content based on the number of regions to describe

    Prognos (R) in the diagnosis of amalgam hypersensitivity - A diagnostic case-control study

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    Objective: We aimed to investigate whether the Prognos (R) device might be a useful tool in the diagnosis of disorders suspected to be due to dental amalgam fillings. Participants and Methods: A diagnostic case-control study was performed in 27 patients who complained about health problems attributed to amalgam ( cases), 27 healthy volunteers with amalgam fillings ( controls I), and 27 healthy amalgam-free volunteers ( controls II). All participants were tested before and after application of 300 mg DMPS (2.3-dimercapto-1-propanesulfonic acid) with Prognos, a diagnostic device for the energetic measurement of Traditional Chinese Medicine meridians. In addition, mercury was measured in blood, urine, and saliva, and a lymphocyte transformation test (LTT) was performed. Results: Diagnoses derived from the first and second Prognos testing did not agree above chance (Cohen's Kappa = -0.11, 95% confidence interval -0.33 to 0.10; p = 0.30). Agreement for secondary outcome measures was poor, too. Prognos measurements did not differ between cases and controls. Correlations with measurements in urine, blood and saliva were low. Conclusion: In this study Prognos could not be shown to be a useful tool in the diagnosis of disorders suspected to be due to dental amalgam fillings

    Nuorten aikuisten osallisuus ja sosiaalinen kuntoutus Lapissa

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    Tutkimuksessa tarkastellaan nuorten aikuisten osallisuutta sosiaalisen kuntoutuksen palvelujen asiakkaina Rovaniemellä, Kittilässä ja Inarissa. Tutkimuksen aineisto koostuu 24 nuoren yksilöhaastatteluista, neljästä sosiaalisen kuntoutuksen palveluntuottajien ryhmähaastattelusta sekä tilastoaineistosta. Nuorten aikuisten osallisuuden tukemisessa korostuu nuorten kokemustiedon, paikallisuuden ja paikallisen kulttuurin merkitykset. Erityisesti kokemustiedon huomioiminen tarjoaa nuorille aikuisille väylän vaikuttaa sosiaalisen kuntouksen palveluprosessiin. Nuorten aikuisten haastatteluista erottuu neljä erilaista toimijuuden roolia (positiota): omaan kuntoutumiseen panostava, yhteisöllinen vastuunkantaja ja toiminnan kehittäjä, etsijä sekä ajelehtija. Eri toimijuuden roolit vaikuttavat siihen, millainen merkitys sosiaalisella kuntoutuksella on nuorille aikuisille. Sosiaalisen kuntoutuksen toteuttamiseen vaikuttaa samanaikaisesti useita ammatillisia ajattelu- ja toimintatapoja (rationaliteetteja). Tärkeää on erityisesti yhteisöllinen toiminta, jossa nuorta tuetaan osana paikallisyhteisöään ja sosiaalisia verkostojaan. Monialaisen yhteistyön merkitys korostuu sosiaalisen kuntoutuksen toteuttamisessa. Sosiaalinen kuntoutus on vielä käsitteenä, palveluna ja ammattikäytäntöinä osin jäsentymätöntä sekä työntekijöille että asiakkaille. Tutkimuksen perusteella sosiaalisen kuntoutuksen sisällölliselle ja käsitteelliselle kehittämiselle on selkeä tarve.30,00 euro

    Utility of oropharyngeal real-time PCR for S. pneumoniae and H. influenzae for diagnosis of pneumonia in adults.

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    Efst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn To access publisher's full text version of this article click on the hyperlink at the bottom of the pageor click on the hyperlink at the To access publisher's full text version of this article, please click on the hyperlink in Additional Links field top of the page marked FilesA lack of sensitive tests and difficulties obtaining representative samples contribute to the challenge in identifying etiology in pneumonia. Upper respiratory tract swabs can be easily collected and analyzed with real-time PCR (rtPCR). Common pathogens such as S. pneumoniae and H. influenzae can both colonize and infect the respiratory tract, complicating the interpretation of positive results. Oropharyngeal swabs were collected (n = 239) prospectively from adults admitted to hospital with pneumonia. Analysis with rtPCR targeting S. pneumoniae and H. influenzae was performed and results compared with sputum cultures, blood cultures, and urine antigen testing for S. pneumoniae. Different Ct cutoff values were applied to positive tests to discern colonization from infection. Comparing rtPCR with conventional testing for S. pneumoniae in patients with all tests available (n = 57) resulted in: sensitivity 87 %, specificity 79 %, PPV 59 % and NPV 94 %, and for H. influenzae (n = 67): sensitivity 75 %, specificity 80 %, PPV 45 % and NPV 94 %. When patients with prior antimicrobial exposure were excluded sensitivity improved: 92 % for S. pneumoniae and 80 % for H. influenzae. Receiver operating characteristic curve analysis demonstrated for S. pneumoniae: AUC = 0.65 (95 % CI 0.51-0.80) and for H. influenzae: AUC = 0.86 (95 % CI 0.72-1.00). Analysis of oropharyngeal swabs using rtPCR proved both reasonably sensitive and specific for diagnosing pneumonia caused by S. pneumoniae and H. influenzae. This method may be a useful diagnostic adjunct to other methods and of special value in patients unable to provide representative lower airway samples.Icelandic Center for Research Rannis Landspitali University Hospital Science Fund University of Iceland Research Fun

    Telomere length and telomerase activity in malignant lymphomas at diagnosis and relapse

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    Telomere length maintenance, in the vast majority of cases executed by telomerase, is a prerequisite for long-term proliferation. Most malignant tumours, including lymphomas, are telomerase-positive and this activity is a potential target for future therapeutic interventions since inhibition of telomerase has been shown to result in telomere shortening and cell death in vitro. One prerequisite for the suitability of anti-telomerase drugs in treating cancer is that tumours exhibit shortened telomeres compared to telomerase-positive stem cells. A scenario is envisioned where the tumour burden is reduced using conventional therapy whereafter remaining tumour cells are treated with telomerase inhibitors. In evaluating the realism of such an approach it is essential to know the effects on telomere status by traditional therapeutic regimens. We have studied the telomere lengths in 47 diagnostic lymphomas and a significant telomere shortening was observed compared to benign lymphoid tissues. In addition, telomere length and telomerase activity were studied in consecutive samples from patients with relapsing non-Hodgkin's lymphomas. Shortened, unchanged and elongated telomere lengths were observed in the relapse samples. The telomere length alterations found in the relapsing lymphomas appeared to be independent of telomerase and rather represented clonal selection random at the telomere length level. These data indicate that anti-telomerase therapy would be suitable in only a fraction of malignant lymphomas. © 2000 Cancer Research Campaig

    Vegetation and the importance of insecticide-treated target siting for control of Glossina fuscipes fuscipes

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    Control of tsetse flies using insecticide-treated targets is often hampered by vegetation re-growth and encroachment which obscures a target and renders it less effective. Potentially this is of particular concern for the newly developed small targets (0.25 high × 0.5 m wide) which show promise for cost-efficient control of Palpalis group tsetse flies. Consequently the performance of a small target was investigated for Glossina fuscipes fuscipes in Kenya, when the target was obscured following the placement of vegetation to simulate various degrees of natural bush encroachment. Catches decreased significantly only when the target was obscured by more than 80%. Even if a small target is underneath a very low overhanging bush (0.5 m above ground), the numbers of G. f. fuscipes decreased by only about 30% compared to a target in the open. We show that the efficiency of the small targets, even in small (1 m diameter) clearings, is largely uncompromised by vegetation re-growth because G. f. fuscipes readily enter between and under vegetation. The essential characteristic is that there should be some openings between vegetation. This implies that for this important vector of HAT, and possibly other Palpalis group flies, a smaller initial clearance zone around targets can be made and longer interval between site maintenance visits is possible both of which will result in cost savings for large scale operations. We also investigated and discuss other site features e.g. large solid objects and position in relation to the water's edge in terms of the efficacy of the small targets

    Optimizing the colour and fabric of targets for the control of the tsetse fly Glossina fuscipes fuscipes

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    Background: Most cases of human African trypanosomiasis (HAT) start with a bite from one of the subspecies of Glossina fuscipes. Tsetse use a range of olfactory and visual stimuli to locate their hosts and this response can be exploited to lure tsetse to insecticide-treated targets thereby reducing transmission. To provide a rational basis for cost-effective designs of target, we undertook studies to identify the optimal target colour. Methodology/Principal Findings: On the Chamaunga islands of Lake Victoria , Kenya, studies were made of the numbers of G. fuscipes fuscipes attracted to targets consisting of a panel (25 cm square) of various coloured fabrics flanked by a panel (also 25 cm square) of fine black netting. Both panels were covered with an electrocuting grid to catch tsetse as they contacted the target. The reflectances of the 37 different-coloured cloth panels utilised in the study were measured spectrophotometrically. Catch was positively correlated with percentage reflectance at the blue (460 nm) wavelength and negatively correlated with reflectance at UV (360 nm) and green (520 nm) wavelengths. The best target was subjectively blue, with percentage reflectances of 3%, 29%, and 20% at 360 nm, 460 nm and 520 nm respectively. The worst target was also, subjectively, blue, but with high reflectances at UV (35% reflectance at 360 nm) wavelengths as well as blue (36% reflectance at 460 nm); the best low UV-reflecting blue caught 3× more tsetse than the high UV-reflecting blue. Conclusions/Significance: Insecticide-treated targets to control G. f. fuscipes should be blue with low reflectance in both the UV and green bands of the spectrum. Targets that are subjectively blue will perform poorly if they also reflect UV strongly. The selection of fabrics for targets should be guided by spectral analysis of the cloth across both the spectrum visible to humans and the UV region

    Oregon Bee Atlas: Wild bee findings from 2019

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    The Oregon Bee Atlas is a new volunteer-led effort to characterize the bee fauna of Oregon State by collecting, preparing and databasing specimens of wild bee species and their plant host records. In 2019 volunteers submitted 25,022 bee specimens across all Oregon counties, representing 224 unique bee species and 45 unique bee genera. Specimens were collected from a total of 352 unique flowering plant genera, resulting in the largest contemporary state-level database of bee-host plant interactions. Volunteers produced valuable occurrence records for species poorly known for the state, and species of conservation concern. The 2019 data builds on the efforts of 2018 in demonstrating the power of a specimen-focused, volunteer wild bee survey

    Oregon Bee Atlas: Wild bee findings from 2019

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    The Oregon Bee Atlas is a new volunteer-led effort to characterize the bee fauna of Oregon State by collecting, preparing and databasing specimens of wild bee species and their plant host records. In 2019 volunteers submitted 25,022 bee specimens across all Oregon counties, representing 224 unique bee species and 45 unique bee genera. Specimens were collected from a total of 352 unique flowering plant genera, resulting in the largest contemporary state-level database of bee-host plant interactions. Volunteers produced valuable occurrence records for species poorly known for the state, and species of conservation concern. The 2019 data builds on the efforts of 2018 in demonstrating the power of a specimen-focused, volunteer wild bee survey
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