Washburn extraction and width of the IUE point spread function

The Washburn Extraction Routine for low dispersion IUE spectra was reviewed. The shape of the point spread function (PSF) in low dispersion spectra is sufficiently well described by a gaussian function. The PSF is in large and small aperture essentially identical and values of sigma are presented. Several advantages of the extraction routine are mentioned

Direct Detection of a (Proto)Binary-Disk System in IRAS 20126+4104

We report the direct detection of a binary/disk system towards the high-mass (proto)stellar object IRAS20126+4104 at infrared wavengths. The presence of a multiple system had been indicated by the precession of the outflow and the double jet system detected earlier at cm-wavelengths. Our new K, L' & M' band infrared images obtained with the UKIRT under exceptional seeing conditions on Mauna Kea are able to resolve the central source for the first time, and we identify two objects separated by ~ 0.5'' (850 AU). The K and L' images also uncover features characteristic of a nearly edge-on disk, similar to many low mass protostars with disks: two emission regions oriented along an outflow axis and separated by a dark lane. The peaks of the L' & M' band and mm-wavelength emission are on the dark lane, presumably locating the primary young star. The thickness of the disk is measured to be ~ 850 AU for radii < 1000 AU. Approximate limits on the NIR magnitudes of the two young stars indicate a high-mass system, although with much uncertainty. These results are a demonstration of the high-mass nature of the system, and the similarities of the star-formation process in the low-mass and high-mass regimes viz. the presence of a disk-accretion stage. The companion is located along the dark lane, consistent with it being in the equatorial/disk plane, indicating a disk-accretion setting for massive, multiple, star-formation.Comment: 12 pages, 3 figures (1 pseudo colour), 1 table; colour figure replaced with jpg file; to be published in ApJL; (back after temoprary withdrawal due to non-scientific reasons.

Glucocorticoid receptor modulators

Diabetes mellitus: pathophysiological changes and therap

Scattering by Interstellar Dust Grains: Optical and Ultraviolet

Scattering and absorption properties at optical and ultraviolet wavelengths are calculated for an interstellar dust model consisting of carbonaceous grains and amorphous silicate grains. Polarization as a function of scattering angle is calculated for selected wavelengths from the IR to the vacuum UV. The widely-used Henyey-Greenstein phase function provides a good approximation for the scattering phase function between ~0.4 and 1 micron, but fails to fit the calculated phase functions at shorter wavelengths and longer wavelengths. A new analytic phase function is presented. It is exact at long wavelengths, and provides a good fit to the numerically-calculated phase function for lambda > 0.27um. Observational determinations of the scattering albedo and show considerable disagreement, especially in the ultraviolet. Possible reasons for this are discussed.Comment: ApJ, accepted. 19 pages, 10 figures. This version includes a new analytic scattering phase function which is an improvement on the Henyey-Greenstein phase function. Sections on X-ray scattering in previous version of this astro-ph submission have been relocated to a separate paper (Draine 2003: astro-ph/0308251

Unravelling the nature of HD 81032 - a new RS CVn Binary

BVR photometric and quasi-simultaneous optical spectroscopic observations of the star HD 81032 have been carried out during the years 2000 - 2004. A photometric period of $18.802 \pm 0.07$ d has been detected for this star. A large group of spots with a migration period of $7.43 \pm 0.07$ years is inferred from the first three years of the data. H$\alpha$ and Ca II H and K emissions from the star indicate high chromospheric activity. The available photometry in the BVRIJHK bands is consistent with spectral type of K0 IV previously found for this star. We have also examined the spectral energy distribution of HD 81032 for the presence of an infrared colour excess using the 2MASS JHK and IRAS photometry, but found no significant excess in any band abovethe normal values expected for a star with this spectral type. We have also analyzed the X-ray emission properties of this star using data obtained by the ROSAT X-ray observatory during its All-Sky Survey phase. An X-ray flare of about 12 hours duration was detected during the two days of X-ray coverage obtained for this star. Its X-ray spectrum, while only containing 345 counts, is inconsistent with a single-temperature component solar-abundance coronal plasma model, but implies either the presence of two or more plasma components, non-solar abundances, or a combination of both of these properties. All of the above properties of HD 81032 suggest that it is a newly identified, evolved RS CVn binary.Comment: 18 pages, 10 figures, 3 tables, Accepted for the publication in JAp

Optical Spectroscopy of Type Ib/c Supernovae

We present 84 spectra of Type Ib/c and Type IIb supernovae (SNe), describing the individual SNe in detail. The relative depths of the helium absorption lines in the spectra of the SNe Ib appear to provide a measurement of the temporal evolution of the SN, with He I 5876 and He I 7065 growing in strength relative to He I 6678 over time. Light curves for three of the SNe Ib provide a sequence for correlating the helium-line strengths. We find that some SNe Ic show evidence for weak helium absorption, but most do not. Aside from the presence or absence of the helium lines, there are other spectroscopic differences between SNe Ib and SNe Ic. On average, the O I 7774 line is stronger in SNe Ic than in SNe Ib. In addition, the SNe Ic have distinctly broader emission lines at late times, indicating either a consistently larger explosion energy and/or lower envelope mass for SNe Ic than for SNe Ib. While SNe Ib appear to be basically homogeneous, the SNe Ic are quite heterogeneous in their spectroscopic characteristics. Three SNe Ic that may have been associated with gamma-ray bursts are also discussed; two of these have clearly peculiar spectra, while the third seems fairly typical.Comment: Accepted for publication in the March issue of AJ. 75 pages, 35 figures, 6 tables included as figures, AASTeX V5.

Spectroscopic monitoring of the luminous blue variable Westerlund1-243 from 2002 to 2009

The massive post-Main Sequence star W243 in the galactic starburst cluster Westerlund 1 has undergone a spectral transformation from a B2Ia supergiant devoid of emission features in 1981 to an A-type supergiant with a rich emission-line spectrum by 2002/03. We used VLT/UVES and VLT/FLAMES to obtain high-resolution spectra on six epochs in 2003/04 (UVES) and ten epochs in 2008/09 (FLAMES). These spectra are used alongside other VLT/FLAMES and NTT/EMMI spectra to follow the evolution of W243 from 2002 to 2009. W243 displays a complex, time-varying spectrum with emission lines of Hydrogen, Helium and Lyman-pumped metals, forbidden lines of Nitrogen and Iron, and a large number of absorption lines from neutral and singly-ionized metals. Many lines are complex emission/absorption blends. The LBV has a current temperature of ~8500K (spectral type A3Ia+), and displays signs of photospheric pulsations and weak episodic mass loss. Nitrogen is highly overabundant, with Carbon and Oxygen depleted, indicative of surface CNO-processed material and considerable previous mass-loss, although current time-averaged mass-loss rates are low. The emission-line spectrum forms at large radii, when material lost by the LBV in a previous mass-loss event is ionized by an unseen hot companion. Monitoring of the near-infrared spectrum suggests that the star has not changed significantly since it finished evolving to the cool state, close to the Humphreys-Davidson limit, in early 2003. [ABRIDGED]Comment: 17 pages, 16 figures, accepted for publication in Astronomy and Astrophysic

The development of novel glucocorticoid receptor antagonists: from rational chemical design to therapeutic efficacy in metabolic disease models

Glucocorticoids regulate numerous processes in human physiology, but deregulated or excessive glucocorticoid receptor (GR) signaling contributes to the development of various pathologies including metabolic syndrome. For this reason, GR antagonists have considerable therapeutic value. Yet, the only GR antagonist that is clinically approved to date - mifepristone - exhibits cross-reactivity with other nuclear steroid receptors like the progesterone receptor. In this study, we set out to identify novel selective GR antagonists by combining rational chemical design with an unbiased in vitro and in vivo screening approach. Using this pipeline, we were able to identify CORT125329 as the compound with the best overall profile from our octahydro series of novel GR antagonists, and demonstrated that CORT125329 does not exhibit cross-reactivity with the progesterone receptor. Further in vivo testing showed beneficial activities of CORT125329 in models for excessive corticosterone exposure and short- and long-term high-fat diet-induced metabolic complications. Upon CORT125329 treatment, most metabolic parameters that deteriorated upon high-fat diet feeding were similarly improved in male and female mice, confirming activity in both sexes. However, some sexually dimorphic effects were observed including male-specific antagonism of GR activity in brown adipose tissue and female-specific lipid lowering activities after short-term CORT125329 treatment. Remarkably, CORT125329 exhibits beneficial metabolic effects despite its lack of GR antagonism in white adipose tissue. Rather, we propose that CORT125329 treatment restores metabolic activity in brown adipose tissue by stimulating lipolysis, mitochondrial activity and thermogenic capacity. In summary, we have identified CORT125329 as a selective GR antagonist with strong beneficial activities in metabolic disease models, paving the way for further clinical investigation.Nephrolog

An evolutionary technique to approximate multiple optimal alignments

The alignment of observed and modeled behavior is an essential aid for organizations, since it opens the door for root-cause analysis and enhancement of processes. The state-of-the-art technique for computing alignments has exponential time and space complexity, hindering its applicability for medium and large instances. Moreover, the fact that there may be multiple optimal alignments is perceived as a negative situation, while in reality it may provide a more comprehensive picture of the model’s explanation of observed behavior, from which other techniques may benefit. This paper presents a novel evolutionary technique for approximating multiple optimal alignments. Remarkably, the memory footprint of the proposed technique is bounded, representing an unprecedented guarantee with respect to the state-of-the-art methods for the same task. The technique is implemented into a tool, and experiments on several benchmarks are provided.Peer ReviewedPostprint (author's final draft

On the radio emitting high mass X-ray binary LS 5039

We present new optical - near-IR spectroscopic and photometric observations of the newly discovered galactic microquasar LS 5039, which indicate a classification for the mass donor in the system of O6.5V((f)). Optical spectroscopy and photometry shows no variability over a timescale of years, and we find no evidence of modulation by, or emission from the compact companion in these data. However significant photometric variability (~0.4 mag) is present in the H and K bands between 1995-2000. Such variability has been observed in other radio bright X-ray binaries where it has been attributed to synchrotron emission from the jet. However, given the non-thermal spectral index of the radio emission in LS 5039 this explanation appears unlikely, predicting a near-IR flux ~3 orders of magnitude too small to contribute significantly at such wavelengths. Nightly optical photometry over a 21 day period between 2000 May-June reveals variability at a level of a few hundredths of a magnitude, with no periodicity or long term trend visible. Likewise, while the radio lightcurves show moderate variability ( per cent of the mean flux density) we find no evidence of periodic modulation - Monte Carlo simulations constrain any such periodic variability to <4 per cent modulation at 2.25 GHz. The differences in behaviour between LS 5039 and Cygnus X-1 - the most closely related radio emitting High Mass X-ray Binary - are likely to be a result of the weaker stellar wind and probable greater orbital separation of LS 5039 compared to Cyg X-1