Tensioactivos. XX. ω-Monoésteres grasos de ditioacetales de azúcares

The preparation of 5-O-lauroyl(myhstoyl, palmitoyl)-D-arabinose ethylendithioacetals, 6-O-lauroyl-D-glucose(D-galactose) ethylendithioacetals and 6-O-decanoyl(lauroyl)-D-mannose ethylendithioacetals is reported. The preparation of 5-O-octanoyl(decanoyl, lauroyl)-L-arabinose diethyldithioacetais is also reported. These compounds were obtained by monoesterification of aldosedithioacetals with the corresponding fatty acid chlorides in pyridine.Se describe la preparación de etilenditioacetales de la 5-O-lauroil(miristoil, palmitoil)- D-arabinosa, de la 6-O-lauroil-D-glucosa(D-galactosa) y de la 6-O-decanoil(lauroil)-D-manosa; y la preparación de dietilditioacetales de la 5-O-octanoil(decanoil, lauroil)-L-arabinosa. La síntesis de estos compuestos se ha realizado por monoesterificación de los ditioacetales de azúcares con los correspondientes cloruros de ácidos grasos en piridina

Evolución de componentes de aceituna (variedad Hojiblanca) durante la maduración

The evolution during ripening of the principal components from olive, Hojiblanca var., was studied. The similarities and differences with other varieties were established.Se estudia la evolución de los componentes fundamentales de aceitunas de la variedad Hojiblanca, durante su maduración, en dos campañas sucesivas. Se establecen semejanzas y diferencias con otras variedades

Preparación y caracterización de fracciones de fibra en aceitunas (Variedad Hojiblanca)

Acid detergent fibre (ADF), neutral detergent fibre (NDF), insoluble fibre (IF) and soluble fibre (SF) were isolated from the flesh of Hojiblanca variety fresh green olives. Composition and recovery of polysaccharides, expressed as neutral sugars content, were studied for each one of these fractions.Se aísla fibra detergente ácido (ADF), detergente neutro (NDF), insoluble (FI) y soluble (FS), de pulpa de aceitunas verdes (variedad Hojiblanca) y se estudia la composición de cada una de estas fracciones, así como la recuperación de polisacáridos de las mismas (contenido en azúcares neutros)

Central America urgently needs to reduce the growing adaptation gap to climate change

Central America is highly impacted by current extreme events associated with climate variability and the adverse effects of climate change, showing high vulnerability compounded by its historical context and socioeconomic structure. In light of the important findings published by the WGII of the IPCC AR6 in 2022 on the adverse effects of climate change on the Central American region, there is still a clear need to improve data availability and to increase the number of studies on projections of changes in the climate, risks, impacts, vulnerability, and adaptation from the region to inform decision-makers and practitioners. The region has seen an increase in the number of adaptation projects implemented; however, there is limited information about their success or failure, and there are few case studies and reviews of lessons learned, highlighting an important gap in the implementation of effective adaptation measures. This article presents a current review of the literature on climatology, hydrology, impacts and vulnerability, mitigation and adaptation responses, action plans, and potential losses and damages in the region. It also proposes actionable recommendations based on the main gaps found and presents a case study of the Central American Dry Corridor, one of the climate change and underdevelopment hotspots of the region. We finish with a discussion highlighting the importance of considering system transitions perspectives and the need to plan and implement more transformational adaptation approaches to reduce further losses and damages and to further address adaptation gaps in Central America

Synthesis and Antiproliferative Activity of Sulfa-Michael Adducts and Thiochromenes Derived from Carbohydrates

The Michael addition reactions of carbohydrate-derived nitroalkenes with ethyl thioglycolate and 2-mercaptobenzyl alcohol were studied. Reactions were conducted under mild, solvent-free conditions with DABCO as a catalyst, affording the corresponding adducts in good yields. Furthermore, compounds resulting from the addition with 2-mercaptobenzyl alcohol were used as starting materials for the synthesis of chiral 3-nitro-2H-thiochromenes. For some of the compounds synthesized herein, the antioxidant and antiproliferative activities against a panel of human solid tumor cell lines were assayed and compared with those of carbohydrate-nitroalkene substrates.Junta de Extremadura GR15022Unión Europea FP7-REGPOT-2012-CT2012-31637-IMBRAI

N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study

Our goal was the evaluation of a series of N-1,2,3-triazole-isatin derivatives for multi-target activity which included cholinesterase (ChE) inhibition and β-amyloid (Aβ) peptide anti-aggregation. The compounds have shown considerable promise as butyrylcholinesterase (BuChE) inhibitors. Although the inhibition of eel acet- ylcholinesterase (eeAChE) was weak, the inhibitions against equine BuChE (eqBuChE) and human BuChE (hBuChE) were more significant with a best inhibition against eqBuChE of 0.46 μM. In some cases, these mo- lecules gave better inhibitions for hBuChE than eqBuChE. For greater insights into their mode of action, mole- cular docking studies were carried out, followed by STD-NMR validation. In addition, some of these compounds showed weak Aβ anti-aggregation activity. Hepatotoxicity studies showed that they were non-hepatoxic and neurotoxicity studies using neurite out- growth experiments led to the conclusion that these compounds are only weakly neurotoxic

A comparative analysis of pose estimation models as enablers for a smart-mirror physical rehabilitation system

Smart mirrors are gaining attention as a smart device that could integrate a set of functionalities intended to assist older adults in their day-to-day life. These devices are seamlessly integrated in the environment, providing a user-friendly interface and naturally fitting into the daily-care routines. People face a mirror several times a day, thus ensuring that any application running on a smart mirror will have several guaranteed interactions per day. It is therefore essential to detect when the user is in front of the mirror and also to interpret what he or she is doing. Very powerful and accurate libraries are currently available, but the limited computational resources and the need to work in real time limit the valid options for smart mirror devices. This paper therefore analyses and evaluates several body pose estimation models in order to determine which one can be deployed in a smart mirror-like device dedicated to supporting older adults in their physical rehabilitation routines.Los espejos inteligentes están ganando atención como un dispositivo inteligente que podría integrar un conjunto de funcionalidades destinadas a ayudar a los adultos mayores en su día a día. Estos dispositivos se integran a la perfección en el entorno, brindan una interfaz fácil de usar y se adaptan naturalmente a las rutinas de cuidado diario. Las personas se enfrentan a un espejo varias veces al día, lo que garantiza que cualquier aplicación que se ejecute en un espejo inteligente tendrá varias interacciones garantizadas por día. Por lo tanto, es fundamental detectar cuándo el usuario está frente al espejo y también interpretar lo que está haciendo. Actualmente se encuentran disponibles bibliotecas muy potentes y precisas, pero los recursos computacionales limitados y la necesidad de trabajar en tiempo real limitan las opciones válidas para los dispositivos espejo inteligentes