Transit Lightcurve Signatures of Artificial Objects

The forthcoming space missions, able to detect Earth-like planets by the transit method, will a fortiori also be able to detect the transit of artificial planet-size objects. Multiple artificial objects would produce lightcurves easily distinguishable from natural transits. If only one artificial object transits, detecting its artificial nature becomes more difficult. We discuss the case of three different objects (triangle, 2-screen, louver-like 6-screen) and show that they have a transit lightcurve distinguishable from the transit of natural planets, either spherical or oblate, although an ambiguity with the transit of a ringed planet exists in some cases. We show that transits, especially in the case of multiple artificial objects, could be used for the emission of attention-getting signals, with a sky coverage comparable to the laser pulse method. The large number of expected planets (several hundreds) to be discovered by the transit method by next space missions will allow to test these ideas.Comment: Accepted for publication in ApJ. Manuscript: 17 pages, 8 figure

Symmetric path integrals for stochastic equations with multiplicative noise

A Langevin equation with multiplicative noise is an equation schematically of the form dq/dt = - F(q) + e(q) xi, where e(q) xi is Gaussian white noise whose amplitude e(q) depends on q itself. I show how to convert such equations into path integrals. The definition of the path integral depends crucially on the convention used for discretizing time, and I specifically derive the correct path integral when the convention used is the natural, time-symmetric one that time derivatives are (q_t - q_{t-\Delta t}) / \Delta t and coordinates are (q_t + q_{t-\Delta t}) / 2. [This is the convention that permits standard manipulations of calculus on the action, like naive integration by parts.] It has sometimes been assumed in the literature that a Stratanovich Langevin equation can be quickly converted to a path integral by treating time as continuous but using the rule \theta(t=0) = 1/2. I show that this prescription fails when the amplitude e(q) is q-dependent.Comment: 8 page

B-52 control configured vehicles: Flight test results

Recently completed B-52 Control Configured Vehicles (CCV) flight testing is summarized, and results are compared to analytical predictions. Results are presented for five CCV system concepts: ride control, maneuver load control, flutter mode control, augmented stability, and fatigue reduction. Test results confirm analytical predictions and show that CCV system concepts achieve performance goals when operated individually or collectively

Spaces of finite element differential forms

We discuss the construction of finite element spaces of differential forms which satisfy the crucial assumptions of the finite element exterior calculus, namely that they can be assembled into subcomplexes of the de Rham complex which admit commuting projections. We present two families of spaces in the case of simplicial meshes, and two other families in the case of cubical meshes. We make use of the exterior calculus and the Koszul complex to define and understand the spaces. These tools allow us to treat a wide variety of situations, which are often treated separately, in a unified fashion.Comment: To appear in: Analysis and Numerics of Partial Differential Equations, U. Gianazza, F. Brezzi, P. Colli Franzone, and G. Gilardi, eds., Springer 2013. v2: a few minor typos corrected. v3: a few more typo correction

Self-diffusion of polymers in cartilage as studied by pulsed field gradient NMR

Pulsed field gradient (PFG) nuclear magnetic resonance (NMR) was used to investigate the self-diffusion behaviour of polymers in cartilage. Polyethylene glycol and dextran with different molecular weights and in different concentrations were used as model compounds to mimic the diffusion behaviour of metabolites of cartilage. The polymer self-diffusion depends extremely on the observation time: The short-time self-diffusion coefficients (diffusion time Delta approximately 15 ms) are subjected to a rather non-specific obstruction effect that depends mainly on the molecular weights of the applied polymers as well as on the water content of the cartilage. The observed self-diffusion coefficients decrease with increasing molecular weights of the polymers and with a decreasing water content of the cartilage. In contrast, the long-time self-diffusion coefficients of the polymers in cartilage (diffusion time Delta approximately 600 ms) reflect the structural properties of the tissue. Measurements at different water contents, different molecular weights of the polymers and varying observation times suggest that primarily the collagenous network of cartilage but also the entanglements of the polymer chains themselves are responsible for the observed restricted diffusion. Additionally, anomalous restricted diffusion was shown to occur already in concentrated polymer solutions

Anomalous exponents at the onset of an instability

Critical exponents are calculated exactly at the onset of an instability, using asymptotic expansiontechniques. When the unstable mode is subject to multiplicative noise whose spectrum at zero frequency vanishes, we show that the critical behavior can be anomalous, i.e. the mode amplitude X scales with departure from onset \mu as $~ \mu^\beta$ with an exponent $\beta$ different from its deterministic value. This behavior is observed in a direct numerical simulation of the dynamo instability and our results provide a possible explanation to recent experimental observations

Which diagnostic tests are most useful in a chest pain unit protocol?

Background The chest pain unit (CPU) provides rapid diagnostic assessment for patients with acute, undifferentiated chest pain, using a combination of electrocardiographic (ECG) recording, biochemical markers and provocative cardiac testing. We aimed to identify which elements of a CPU protocol were most diagnostically and prognostically useful. Methods The Northern General Hospital CPU uses 2–6 hours of serial ECG / ST segment monitoring, CK-MB(mass) on arrival and at least two hours later, troponin T at least six hours after worst pain and exercise treadmill testing. Data were prospectively collected over an eighteen-month period from patients managed on the CPU. Patients discharged after CPU assessment were invited to attend a follow-up appointment 72 hours later for ECG and troponin T measurement. Hospital records of all patients were reviewed to identify adverse cardiac events over the subsequent six months. Diagnostic accuracy of each test was estimated by calculating sensitivity and specificity for: 1) acute coronary syndrome (ACS) with clinical myocardial infarction and 2) ACS with myocyte necrosis. Prognostic value was estimated by calculating the relative risk of an adverse cardiac event following a positive result. Results Of the 706 patients, 30 (4.2%) were diagnosed as ACS with myocardial infarction, 30 (4.2%) as ACS with myocyte necrosis, and 32 (4.5%) suffered an adverse cardiac event. Sensitivities for ACS with myocardial infarction and myocyte necrosis respectively were: serial ECG / ST segment monitoring 33% and 23%; CK-MB(mass) 96% and 63%; troponin T (using 0.03 ng/ml threshold) 96% and 90%. The only test that added useful prognostic information was exercise treadmill testing (relative risk 6 for cardiac death, non-fatal myocardial infarction or arrhythmia over six months). Conclusion Serial ECG / ST monitoring, as used in our protocol, adds little diagnostic or prognostic value in patients with a normal or non-diagnostic initial ECG. CK-MB(mass) can rule out ACS with clinical myocardial infarction but not myocyte necrosis(defined as a troponin elevation without myocardial infarction). Using a low threshold for positivity for troponin T improves sensitivity of this test for myocardial infarction and myocardial necrosis. Exercise treadmill testing predicts subsequent adverse cardiac events

A mathematical model for the capillary endothelial cell-extracellular matrix interactions in wound-healing angiogenesis

Angiogenesis, the process by which new blood capillaries grow into a tissue from surrounding parent vessels, is a key event in dermal wound healing, malignant-tumour growth, and other pathologic conditions. In wound healing, new capillaries deliver vital metabolites such as amino acids and oxygen to the cells in the wound which are involved in a complex sequence of repair processes. The key cellular constituents of these new capillaries are endothelial cells: their interactions with soluble biochemical and insoluble extracellular matrix (ECM) proteins have been well documented recently, although the biological mechanisms underlying wound-healing angiogenesis are incompletely understood. Considerable recent research, including some continuum mathematical models, have focused on the interactions between endothelial cells and soluble regulators (such as growth factors). In this work, a similar modelling framework is used to investigate the roles of the insoluble ECM substrate, of which collagen is the predominant macromolecular protein. Our model consists of a partial differential equation for the endothelial-cell density (as a function of position and time) coupled to an ordinary differential equation for the ECM density. The ECM is assumed to regulate cell movement (both random and directed) and proliferation, whereas the cells synthesize and degrade the ECM. Analysis and numerical solutions of these equations highlights the roles of these processes in wound-healing angiogenesis. A nonstandard approximation analysis yields insight into the travel ling-wave structure of the system. The model is extended to two spatial dimensions (parallel and perpendicular to the plane of the skin), for which numerical simulations are presented. The model predicts that ECM-mediated random motility and cell proliferation are key processes which drive angiogenesis and that the details of the functional dependence of these processes on the ECM density, together with the rate of ECM remodelling, determine the qualitative nature of the angiogenic response. These predictions are experimentally testable, and they may lead towards a greater understanding of the biological mechanisms involved in wound-healing angiogenesis

Longitudinal Losses Due to Breathing Mode Excitation in Radiofrequency Linear Accelerators

Transverse breathing mode oscillations in a particle beam can couple energy into longitudinal oscillations in a bunch of finite length and cause significant losses. We develop a model that illustrates this effect and explore the dependence on mismatch size, space-charge tune depression, longitudinal focusing strength, bunch length, and RF bucket length