Regulación epigenética del IFN-y en tuberculosis

M. tuberculosis (Mtb) es el principal asesino microbiológico en el mundo. Las modificaciones epigenéticas son claves en la plasticidad del sistema inmune y como mediadores entre el ambiente y los fenotipos celulares. El IFN-v, media la respuesta protectiva frente a Mtb, pero se desconocen los mecanismos epigenéticos que regularían su activación y mediarían la susceptibilidad a la tuberculosis.Área: Ciencias Biológicas, Ambiente y Salud

The wave nature of biomolecules and fluorofullerenes

We demonstrate quantum interference for tetraphenylporphyrin, the first biomolecule exhibiting wave nature, and for the fluorofullerene C60F48 using a near-field Talbot-Lau interferometer. For the porphyrins, which are distinguished by their low symmetry and their abundant occurence in organic systems, we find the theoretically expected maximal interference contrast and its expected dependence on the de Broglie wavelength. For C60F48 the observed fringe visibility is below the expected value, but the high contrast still provides good evidence for the quantum character of the observed fringe pattern. The fluorofullerenes therefore set the new mark in complexity and mass (1632 amu) for de Broglie wave experiments, exceeding the previous mass record by a factor of two.Comment: 5 pages, 4 figure

The Sum over Topologies in Three-Dimensional Euclidean Quantum Gravity

In Hawking's Euclidean path integral approach to quantum gravity, the partition function is computed by summing contributions from all possible topologies. The behavior such a sum can be estimated in three spacetime dimensions in the limit of small cosmological constant. The sum over topologies diverges for either sign of $\Lambda$, but for dramatically different reasons: for $\Lambda>0$, the divergent behavior comes from the contributions of very low volume, topologically complex manifolds, while for $\Lambda<0$ it is a consequence of the existence of infinite sequences of relatively high volume manifolds with converging geometries. Possible implications for four-dimensional quantum gravity are discussed.Comment: 12 pages (LaTeX), UCD-92-1

The Stern-Gerlach Experiment Revisited

The Stern-Gerlach-Experiment (SGE) of 1922 is a seminal benchmark experiment of quantum physics providing evidence for several fundamental properties of quantum systems. Based on today's knowledge we illustrate the different benchmark results of the SGE for the development of modern quantum physics and chemistry. The SGE provided the first direct experimental evidence for angular momentum quantization in the quantum world and thus also for the existence of directional quantization of all angular momenta in the process of measurement. It measured for the first time a ground state property of an atom, it produced for the first time a `spin-polarized' atomic beam, it almost revealed the electron spin. The SGE was the first fully successful molecular beam experiment with high momentum-resolution by beam measurements in vacuum. This technique provided a new kinematic microscope with which inner atomic or nuclear properties could be investigated. The original SGE is described together with early attempts by Einstein, Ehrenfest, Heisenberg, and others to understand directional quantization in the SGE. Heisenberg's and Einstein's proposals of an improved multi-stage SGE are presented. The first realization of these proposals by Stern, Phipps, Frisch and Segr\`e is described. The set-up suggested by Einstein can be considered an anticipation of a Rabi-apparatus. Recent theoretical work is mentioned in which the directional quantization process and possible interference effects of the two different spin states are investigated. In full agreement with the results of the new quantum theory directional quantization appears as a general and universal feature of quantum measurements. One experimental example for such directional quantization in scattering processes is shown. Last not least, the early history of the `almost' discovery of the electron spin in the SGE is revisited.Comment: 50pp, 17 fig

Internally Electrodynamic Particle Model: Its Experimental Basis and Its Predictions

The internally electrodynamic (IED) particle model was derived based on overall experimental observations, with the IED process itself being built directly on three experimental facts, a) electric charges present with all material particles, b) an accelerated charge generates electromagnetic waves according to Maxwell's equations and Planck energy equation and c) source motion produces Doppler effect. A set of well-known basic particle equations and properties become predictable based on first principles solutions for the IED process; several key solutions achieved are outlined, including the de Broglie phase wave, de Broglie relations, Schr\"odinger equation, mass, Einstein mass-energy relation, Newton's law of gravity, single particle self interference, and electromagnetic radiation and absorption; these equations and properties have long been broadly experimentally validated or demonstrated. A specific solution also predicts the Doebner-Goldin equation which emerges to represent a form of long-sought quantum wave equation including gravity. A critical review of the key experiments is given which suggests that the IED process underlies the basic particle equations and properties not just sufficiently but also necessarily.Comment: Presentation at the 27th Int Colloq on Group Theo Meth in Phys, 200

On the asymptotic formula for Goldbach numbers in short intervals

Let $R(k)=\sum\limits_{l+m=k}\Lambda(l)\Lambda(m)$, \Sing(k) = 2 \prod\limits_{p>2}\left(1-\frac{1}{(p-1)^2}\right) \prod\limits_{\substack{ p\mid k\\ p>2 }} \left(\frac{p-1}{p-2}\right) if $k$ is even and \Sing(k) =0 if $k$ is odd. It is known that R(k) \sim k\Sing(k) as $N\to \infty$ for almost all $k\in [N,2N]$ and that \sum_{k\in [n,n+H)}R(k) \sim \sum_{k\in [n,n+H)} k\Sing(k) \quad\hbox{for} \quad n\to \infty \eqno{(1)} uniformly for $H\geq n^{1/6+\epsilon}$. Here we prove, assuming $N^\epsilon\leq H\leq N^{1/6+\epsilon}$ and $N\to\infty$, that (1) holds for almost all $n\in [N,2N]$

Stacking faults and superstructures in a layered brownmillerite

Stacking faults in Ca4Fe2Mn0.5Ti0.5O9 have been examined using X-ray diffraction and high-resolution transmission electron microscopy. Electron diffraction revealed two superstructures with ordered stacking sequences

Real quadratic fields with large class number

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46217/1/208_2005_Article_BF01351721.pd

Engolo and Capoeira. From Ethnic to Diasporic Combat Games in the Southern Atlantic

This article provides a re-examination of the main Afrocentric narrative of capoeira origins, the engolo or ‘Zebra Dance’, in light of historical primary sources and new ethnographic evidence gathered during fieldwork in south-west Angola. By examining engolo’s bodily techniques, its socio-historical context and cultural meanings, the piece emphasises its insertion into a pastoral lifestyle and highlights the relatively narrow ethnic character of the practice in Angola. This analysis and the comparison with capoeira helps us to develop certain hypotheses about the formation, migration, and re-invention of diasporic combat games between southern Angola and coastal Brazil, and more broadly, to increase our understanding of how African cultures spread across the southern Atlantic