958 research outputs found
Rocks and Hard Places: Exploring Educational Psychologists’ Perspectives on “Off-Rolling” or Illegal Exclusionary Practices in Mainstream Secondary Schools in England
Research being undertaken by the Universities of Exeter and Plymouth is exploring educational psychologists’ knowledge of, and perspectives on, exclusionary practices in schools in England, particularly illegal practices referred to as “off-rolling”. Preliminary findings from the survey element of a mixed methods research project are reported here. The role of business models in the provision of educational psychology services to schools is considered through the conceptual lens of Giroux, Agamben and Ball to highlight ambiguities around the client relationship and to recast individualised ethical dilemmas as systemic features that inhibit direct challenges to school practices relating to inclusion. It is suggested that traded and privatised services risk implicating educational psychologists in schools’ management of the (in)visibility of “off-rolling” and the manufactured legitimacy of varied exclusionary practices
Magnetic behavior of Sm-Co-based permanent magnets during order/disorder phase transformations
The structural transformation from the metastable disordered TbCu7-type SmCo7 structure to the equilibrium ordered Th2Zn17-type Sm2Co17 structure was revealed by x-ray diffraction analysis using Reitveld refinement. The magnetic properties depended strongly on the stage of the transformation, as the coercivity strongly depended on the annealing temperature. The as-solidified alloy in the TbCu7-type structure had a coercivity of 4 kOe, which increased to greater than 9 kOe. The coercivity decreased to around 5 kOe as the transformation neared completion upon annealing at higher temperatures. The magnetization processes were also strongly influenced by the structural state. Initially it was totally controlled by nucleation followed by the domain wall pinning-controlled magnetization process
Magnetic behavior of Sm-Co-based permanent magnets during order/disorder phase transformations
The structural transformation from the metastable disordered TbCu7-type SmCo7 structure to the equilibrium ordered Th2Zn17-type Sm2Co17 structure was revealed by x-ray diffraction analysis using Reitveld refinement. The magnetic properties depended strongly on the stage of the transformation, as the coercivity strongly depended on the annealing temperature. The as-solidified alloy in the TbCu7-type structure had a coercivity of 4 kOe, which increased to greater than 9 kOe. The coercivity decreased to around 5 kOe as the transformation neared completion upon annealing at higher temperatures. The magnetization processes were also strongly influenced by the structural state. Initially it was totally controlled by nucleation followed by the domain wall pinning-controlled magnetization process
Structural and magnetic properties of Pr-alloyed MnBi nanostructures
The structural and magnetic properties of Pr-alloyed MnBi (short MnBi-Pr)
nanostructures with a range of Pr concentrations have been investigated. The
nanostructures include thin films having Pr concentrations 0, 2, 3, 5 and 9
atomic percent and melt-spun ribbons having Pr concentrations 0, 2, 4 and 6
percent respectively. Addition of Pr into the MnBi lattice has produced a
significant change in the magnetic properties of these nanostructures including
an increase in coercivity and structural phase transition temperature, and a
decrease in saturation magnetization and anisotropy energy. The highest value
of coercivity measured in the films is 23 kOe and in the ribbons is 5.6 kOe.
The observed magnetic properties are explained as the consequences of competing
ferromagnetic and antiferromagnetic interactions
Order-disorder transformations in Sm–Co and Sm–Co–ZrC systems with 2-17 stoichiometry
This work investigates the order-disorder transformations utilizing time-resolved x-ray diffraction at the Advanced Photon Source. The metastable phases that can form during the order-disorder transformations in the Sm–Co intermetallics have the potential to produce materials with enhanced permanent magnetic properties. The high-temperature experiments transformed the disordered alloys with the TbCu7-type structure obtained by rapid solidification into the mixture of the hexagonal and rhombohedral ordered structures at 1375 K. The ordering process and the role of the ZrC alloying on the phase formation and ordering transformations were examined. The results showed the formation of shoulders of the fundamental peaks and superlattice peak broadening prior to complete ordering. The lattice parameters expanded linearly up to the onset of ordering, after which an abrupt change of slope was observed. The change in slope suggests a nucleation and growth mechanism for the ordering transformation. The effect of ZrC alloying promoted the formation of the disordered structure in the as-solidified state and lowered the onset of the ordering temperature
Hyperinsulinism-hyperammonaemia syndrome: novel mutations in the GLUD1 gene and genotype-phenotype correlations
Background: Activating mutations in the GLUD1 gene (which encodes for the intra-mitochondrial enzyme glutamate dehydrogenase, GDH) cause the hyperinsulinism–hyperammonaemia (HI/HA) syndrome. Patients present with HA and leucine-sensitive hypoglycaemia. GDH is regulated by another intra-mitochondrial enzyme sirtuin 4 (SIRT4). Sirt4 knockout mice demonstrate activation of GDH with increased amino acid-stimulated insulin secretion.
Objectives: To study the genotype–phenotype correlations in patients with GLUD1 mutations. To report the phenotype and functional analysis of a novel mutation (P436L) in the GLUD1 gene associated with the absence of HA.
Patients and methods: Twenty patients with HI from 16 families had mutational analysis of the GLUD1 gene in view of HA (n=19) or leucine sensitivity (n=1). Patients negative for a GLUD1 mutation had sequence analysis of the SIRT4 gene. Functional analysis of the novel P436L GLUD1 mutation was performed.
Results: Heterozygous missense mutations were detected in 15 patients with HI/HA, 2 of which are novel (N410D and D451V). In addition, a patient with a normal serum ammonia concentration (21 µmol/l) was heterozygous for a novel missense mutation P436L. Functional analysis of this mutation confirms that it is associated with a loss of GTP inhibition. Seizure disorder was common (43%) in our cohort of patients with a GLUD1 mutation. No mutations in the SIRT4 gene were identified.
Conclusion: Patients with HI due to mutations in the GLUD1 gene may have normal serum ammonia concentrations. Hence, GLUD1 mutational analysis may be indicated in patients with leucine sensitivity; even in the absence of HA. A high frequency of epilepsy (43%) was observed in our patients with GLUD1 mutations
Electron diffraction study of cobalt-rich Hf-Co
Intermetallic compounds having compositions from HfCo4 to HfCo8 were investigated by transmission electron microscopy, selected-area electron diffraction, and energy-dispersive x-ray spectroscopy. A major crystalline phase, closely related to the orthorhombic Zr2Co11 phase in structure, has been observed in the samples with the composition ranges from HfCo6 to HfCo8. The phase, referred to as either Hf2Co11 or HfCo7 phase in the literature, is actually one common phase, having a broad composition range and referred to as ÎĽ-phase in the present paper. In addition to the ÎĽ-phase, we have found coexisted fcc-Co phase and a minor Hf2Co7 phase. The Hf6Co23 phase has been identified in the HfCo4 and HfCo5 samples. Tilt-series electron diffraction revealed that the ÎĽ-phase is a one-dimensional incommensurate structure, which can be described approximately as B-centered orthorhombic with a = 0.47 nm, b = 0.82 nm, and c = 3.86 nm
A longitudinal study investigating change in BMI z-score in primary school-aged children and the association of child BMI z-score with parent BMI
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