Pilot study of the air-Q intubating laryngeal airway in clinical use

The air-Q Intubating Laryngeal Airway (ILA) is a newly introduced extraglottic airway device. In this pilot study, we evaluated its use as a routine airway device during positive pressure ventilation. Ease of endotracheal intubation through the device was also assessed. Fifty-nine ASA I and II patients undergoing elective surgery received an air-Q ILA and an endotracheal tube where indicated. Insertion, ventilation and intubation characteristics were noted, as well as throat morbidity and occurrence of adverse events. An air-Q ILA was successfully inserted in 100% of patients. Mean leak pressure was 19±5 cmH2O. Endotracheal intubation was indicated in 19 patients and successful in 58% on the first attempt and 74% in total. Ten percent of the study patients were noted to have dysphagia. One patient was diagnosed with bilateral lingual nerve injury but made a complete recovery in four weeks. The air-Q ILA is an adequate extraglottic airway device in terms of insertion and ventilation. However, the proposed advantage of ease of endotracheal intubation requires further investigation.</p

Pilot study of the air-Q intubating laryngeal airway in clinical use

The air-Q Intubating Laryngeal Airway (ILA) is a newly introduced extraglottic airway device. In this pilot study, we evaluated its use as a routine airway device during positive pressure ventilation. Ease of endotracheal intubation through the device was also assessed. Fifty-nine ASA I and II patients undergoing elective surgery received an air-Q ILA and an endotracheal tube where indicated. Insertion, ventilation and intubation characteristics were noted, as well as throat morbidity and occurrence of adverse events. An air-Q ILA was successfully inserted in 100% of patients. Mean leak pressure was 19±5 cmH2O. Endotracheal intubation was indicated in 19 patients and successful in 58% on the first attempt and 74% in total. Ten percent of the study patients were noted to have dysphagia. One patient was diagnosed with bilateral lingual nerve injury but made a complete recovery in four weeks. The air-Q ILA is an adequate extraglottic airway device in terms of insertion and ventilation. However, the proposed advantage of ease of endotracheal intubation requires further investigation.</p

"Caring for Insiderness": Phenomenologically informed insights that can guide practice.

Understanding the ‘‘insider’’ perspective has been a pivotal strength of qualitative research. Further than this, within the more applied fields in which the human activity of ‘‘caring’’ takes place, such understanding of ‘‘what it is like’’ for people from within their lifeworlds has also been acknowledged as the foundational starting point in order for ‘‘care’’ to be caring. But we believe that more attention needs to be paid to this foundational generic phenomenon: what it means to understand the ‘‘insiderness’’ of another, but more importantly, how to act on this in caring ways. We call this human phenomenon ‘‘caring for insiderness.’’ Drawing on existing phenomenological studies of marginal caring situations at the limits of caring capability, and through a process of phenomenologically oriented reflection, we interrogated some existential themes implicit in these publications that could lead to deeper insights for both theoretical and applied purposes. The paper provides direction for practices of caring by highlighting some dangers as well as some remedies along this path

20 cm VLA Radio-Continuum Study of M31 - Images and Point Source Catalogues

We present a series of new high-sensitivity and high-resolution radio-continuum images of M31 at \lambda=20 cm (\nu=1.4 GHz). These new images were produced by merging archived 20 cm radio-continuum observations from the Very Large Array (VLA) telescope. Images presented here are sensitive to rms=60 \mu Jy and feature high angular resolution (<10"). A complete sample of discrete radio sources have been catalogued and analysed across 17 individual VLA projects. We identified a total of 864 unique discrete radio sources across the field of M31. One of the most prominent regions in M31 is the ring feature for which we estimated total integrated flux of 706 mJy at \lambda=20 cm. We compare here, detected sources to those listed in Gelfand et al. (2004) at \lambda=92 cm and find 118 sources in common to both surveys. The majority (61%) of these sources exhibit a spectral index of \alpha <-0.6 indicating that their emission is predominantly non-thermal in nature. That is more typical for background objects.Comment: 28 pages, 25 figures, accepted for publication in the Serbian Astronomical Journa

Cortical–subcortical interactions in hypersomnia disorders: Mechanisms underlying cognitive and behavioral aspects of the sleep–wake cycle

Subcortical circuits mediating sleep–wake functions have been well characterized in animal models, and corroborated by more recent human studies. Disruptions in these circuits have been identified in hypersomnia disorders (HDs) such as narcolepsy and Kleine–Levin Syndrome, as well as in neurodegenerative disorders expressing excessive daytime sleepiness. However, the behavioral expression of sleep–wake functions is not a simple on-or-off state determined by subcortical circuits, but encompasses a complex range of behaviors determined by the interaction between cortical networks and subcortical circuits. While conceived as disorders of sleep, HDs are equally disorders of wake, representing a fundamental instability in neural state characterized by lapses of alertness during wake. These episodic lapses in alertness and wakefulness are also frequently seen in neurodegenerative disorders where electroencephalogram demonstrates abnormal function in cortical regions associated with cognitive fluctuations (CFs). Moreover, functional connectivity MRI shows instability of cortical networks in individuals with CFs. We propose that the inability to stabilize neural state due to disruptions in the sleep–wake control networks is common to the sleep and cognitive dysfunctions seen in hypersomnia and neurodegenerative disorders

On the role of the Knudsen layer in rapid granular flows

A combination of molecular-dynamics simulations, theoretical predictions, and previous experiments are used in a two-part study to determine the role of the Knudsen layer in rapid granular flows. First, a robust criterion for the identification of the thickness of the Knudsen layer is established: a rapid deterioration in Navier-Stokes-order prediction of the heat flux is found to occur in the Knudsen layer. For (experimental) systems in which heat flux measurements are not easily obtained, a rule-of-thumb for estimating the Knudsen layer thickness follows, namely that such effects are evident within 2.5 (local) mean free paths of a given boundary. Second, comparisons of simulation and experimental data with Navier-Stokes order theory are used to provide a measure as to when Knudsen layer effects become non-negligible. Specifically, predictions that do not account for the presence of a Knudsen layer appear reliable for Knudsen layers collectively composing up to 20% of the domain, whereas deterioration of such predictions becomes apparent when the domain is fully comprised of the Knudsen layer.Comment: 9 figures, accepted to Journal of Fluid Mechanic

Radio Galaxy Zoo: Knowledge Transfer Using Rotationally Invariant Self-Organising Maps

With the advent of large scale surveys the manual analysis and classification of individual radio source morphologies is rendered impossible as existing approaches do not scale. The analysis of complex morphological features in the spatial domain is a particularly important task. Here we discuss the challenges of transferring crowdsourced labels obtained from the Radio Galaxy Zoo project and introduce a proper transfer mechanism via quantile random forest regression. By using parallelized rotation and flipping invariant Kohonen-maps, image cubes of Radio Galaxy Zoo selected galaxies formed from the FIRST radio continuum and WISE infrared all sky surveys are first projected down to a two-dimensional embedding in an unsupervised way. This embedding can be seen as a discretised space of shapes with the coordinates reflecting morphological features as expressed by the automatically derived prototypes. We find that these prototypes have reconstructed physically meaningful processes across two channel images at radio and infrared wavelengths in an unsupervised manner. In the second step, images are compared with those prototypes to create a heat-map, which is the morphological fingerprint of each object and the basis for transferring the user generated labels. These heat-maps have reduced the feature space by a factor of 248 and are able to be used as the basis for subsequent ML methods. Using an ensemble of decision trees we achieve upwards of 85.7% and 80.7% accuracy when predicting the number of components and peaks in an image, respectively, using these heat-maps. We also question the currently used discrete classification schema and introduce a continuous scale that better reflects the uncertainty in transition between two classes, caused by sensitivity and resolution limits

Validation of the Finnish version of the food allergy quality of life questionnaire–parent form (F-FAQLQ-PF)

Aim: Specific questionnaires about food allergy and health-related quality of life (HRQoL) have been developed and validated in several languages, but not Finnish. We aimed to validate the Finnish Food Allergy Quality of Life Questionnaire-Parent Form (FAQLQ-PF) for children under age 13 years.Methods: The original FAQLQ-PF and Food Allergy Independent Measure (FAIM) were translated into Finnish per World Health Organisation guidelines and tested by 72 parents of children under age 13 years with suspected severe peanut or tree nut allergy who were recruited at Allergy Centre in Tampere University Hospital in Tampere, Finland. We calculated the construct validity of the questionnaire by calculating the coefficients between the two measures and used Cronbach's alpha to establish the internal consistency.Results: The FAQLQ-PF showed strong correlations with domain structure and internal consistency, based on Spearman's correlations (rho) for the HRQoL questions, FAIM questions and FAIM mean values. The total questionnaire score correlated significantly with the mean FAIM (rho = 0.95, p &lt; 0.001) and individual FAIM questions. The FAQLQ-PF and domains had good or excellent internal consistency (Cronbach's alpha &gt;0.70).Conclusion: The Finnish FAQLQ-PF demonstrated good construct validity and excellent internal consistency for measuring food allergy HRQoL in children under age 13 years.</p

Validation of the Finnish version of the food allergy quality of life questionnaire–parent form (F-FAQLQ-PF)

Aim: Specific questionnaires about food allergy and health-related quality of life (HRQoL) have been developed and validated in several languages, but not Finnish. We aimed to validate the Finnish Food Allergy Quality of Life Questionnaire-Parent Form (FAQLQ-PF) for children under age 13 years.Methods: The original FAQLQ-PF and Food Allergy Independent Measure (FAIM) were translated into Finnish per World Health Organisation guidelines and tested by 72 parents of children under age 13 years with suspected severe peanut or tree nut allergy who were recruited at Allergy Centre in Tampere University Hospital in Tampere, Finland. We calculated the construct validity of the questionnaire by calculating the coefficients between the two measures and used Cronbach's alpha to establish the internal consistency.Results: The FAQLQ-PF showed strong correlations with domain structure and internal consistency, based on Spearman's correlations (rho) for the HRQoL questions, FAIM questions and FAIM mean values. The total questionnaire score correlated significantly with the mean FAIM (rho = 0.95, p &lt; 0.001) and individual FAIM questions. The FAQLQ-PF and domains had good or excellent internal consistency (Cronbach's alpha &gt;0.70).Conclusion: The Finnish FAQLQ-PF demonstrated good construct validity and excellent internal consistency for measuring food allergy HRQoL in children under age 13 years.</p

Validation of the Finnish version of the food allergy quality of life questionnaire–parent form (F-FAQLQ-PF)

Aim: Specific questionnaires about food allergy and health-related quality of life (HRQoL) have been developed and validated in several languages, but not Finnish. We aimed to validate the Finnish Food Allergy Quality of Life Questionnaire-Parent Form (FAQLQ-PF) for children under age 13 years.Methods: The original FAQLQ-PF and Food Allergy Independent Measure (FAIM) were translated into Finnish per World Health Organisation guidelines and tested by 72 parents of children under age 13 years with suspected severe peanut or tree nut allergy who were recruited at Allergy Centre in Tampere University Hospital in Tampere, Finland. We calculated the construct validity of the questionnaire by calculating the coefficients between the two measures and used Cronbach's alpha to establish the internal consistency.Results: The FAQLQ-PF showed strong correlations with domain structure and internal consistency, based on Spearman's correlations (rho) for the HRQoL questions, FAIM questions and FAIM mean values. The total questionnaire score correlated significantly with the mean FAIM (rho = 0.95, p &lt; 0.001) and individual FAIM questions. The FAQLQ-PF and domains had good or excellent internal consistency (Cronbach's alpha &gt;0.70).Conclusion: The Finnish FAQLQ-PF demonstrated good construct validity and excellent internal consistency for measuring food allergy HRQoL in children under age 13 years.</p