Rifting and Mafic Magmatism in the Hebridean Basins

Acknowledgements and Funding Research in the BPIP was supported by NERC grant GR9/1581, and the Carnegie Trust for the Universities of Scotland. H. Rollinson and E. Gazel are thanked for helpful and constructive criticisms, particularly of the modelling aspects of the paper, and T. Rooney is thanked for invaluable scientific and editorial assistance.Peer reviewedPostprin

Scientific drilling of the Boltysh impact crater, Ukraine

Introduction: The Boltysh crater has been known for several decades and was first drilled in the 1960s as part of a study of economic oil shale deposits. Unfortunately, the cores were not curated and have been lost. We have re-drilled the impact crater and have recovered a near continuous record of ~400 m of organicrich sediments together with 15 m of suevite

Frontier exploration and the North Atlantic Igneous Province : new insights from a 2.6 km offshore volcanic sequence in the NE Faroe–Shetland Basin

Acknowledgements and Funding This work was funded by Chevron. The authors would like to acknowledge the Chevron West of Shetlands team along with the Joint Venture partners OMV, Faroe Petroleum and Indemitsu for access to data along with permission to publish this study. PGS is thanked for access to the Corona Ridge Regional Geostreamer (CRRG) data and permission to publish the seismic line. The paper was improved thanks to insightful reviews by S. M. Jones and A. Saunders, which substantially improved an earlier draft. J. Still and F. Thompson gave invaluable technical support at the University of Aberdeen, and K. Wall helped with real-time cuttings analysis.Peer reviewedPostprin

Organic geochemistry of the crater-fill sediments from Boltysh impact crater, Ukraine

The Boltysh impact crater, is a complex structure formed on the basement rocks of the Ukrainian shield which has been dated at 65.17±0.64 Ma [1]. The Boltysh crater has been know for several decades and was originally drilled in the 1960s-1980s in a study of economic oil shale deposits. Unfortunately, the cores were not curated and have been lost. However we have recently re-drilled the impact crater and have recovered a near continuous record of ~400 m of organic rich sediments deposited in a deep isolated lake which overlie the basement rocks spanning a period ~10 Ma. At 24km diameter, Boltysh will not have contributed substantially to the worldwide devastation at the end of the Cretaceous. However, the precise age of the Boltysh impact relative to the Chicxulub impact and its location on a stable low lying coastal plain which allowed formation of the postimpact crater lake make it a particularly important locality. After the impact, the crater quickly filled with water in a short marine phase but returned to fresh water which persisted for >10Ma [2]. These strata contain a valuable record of Paleogene environmental change in central Europe, and one of very few terrestrial records of the KT event. This pre-eminent record of the Paleogene can help us to answer several related scientific questions including the relative age of Boltysh compared with Chicxulub, recovery from the impact, and later climate signals. The organic geochemistry and playnology indicate main inputs to be algal and higher plant within most of the core although there are some marked changes in inputs in some sections. A number of carbon isotope excursions are also present within the core which are currently being further investigated

Accretion Discs in Blazars

The characteristic properties of blazars (rapid variability, strong polarization, high brightness) are widely attributed to a powerful relativistic jet oriented close to our line of sight. Despite the spectral energy distributions (SEDs) being strongly jet-dominated, a "big blue bump" has been recently detected in sources known as flat spectrum radio quasars (FSRQs). These new data provide a unique opportunity to observationally test coupled jet-disc accretion models in these extreme sources. In particular, as energy and angular momentum can be extracted by a jet magnetically coupled to the accretion disc, the thermal disc emission spectrum may be modified from that predicted by the standard model for disc accretion. We compare the theoretically predicted jet-modified accretion disc spectra against the new observations of the "big blue bump" in FSRQs. We find mass accretion rates that are higher, typically by a factor of two, than predicted by standard accretion disc theory. Furthermore, our results predict that the high redshift blazars PKS 0836+710, PKS 2149-307, B2 0743+25 and PKS 0537-286 may be predominantly powered by a low or moderate spin (a < 0.6) black hole with high mass accretion rates mdot_a ~ 50 - 200 msol/yr, while 3C 273 harbours a rapidly spinning black hole (a = 0.97) with mdot_a ~ 20 msol/yr. We also find that the black hole masses in these high redshift sources must be > 5 * 10^9 msol.Comment: Accepted for publication (17 August 2009) in MNRA

Rhinosporidium seeberi: a human pathogen from a novel group of aquatic protistan parasites.

Rhinosporidium seeberi, a microorganism that can infect the mucosal surfaces of humans and animals, has been classified as a fungus on the basis of morphologic and histochemical characteristics. Using consensus polymerase chain reaction (PCR), we amplified a portion of the R. seeberi 18S rRNA gene directly from infected tissue. Analysis of the aligned sequence and inference of phylogenetic relationships showed that R. seeberi is a protist from a novel clade of parasites that infect fish and amphibians. Fluorescence in situ hybridization and R. seeberi- specific PCR showed that this unique 18S rRNA sequence is also present in other tissues infected with R. seeberi. Our data support the R. seeberi phylogeny recently suggested by another group. R. seeberi is not a classic fungus, but rather the first known human pathogen from the DRIPs clade, a novel clade of aquatic protistan parasites (Ichthyosporea)

Effective elements of cognitive behaviour therapy for psychosis: results of a novel type of subgroup analysis based on principal stratification

Background. Meta-analyses show that cognitive behaviour therapy for psychosis (CBT-P) improves distressing positive symptoms. However, it is a complex intervention involving a range of techniques. No previous study has assessed the delivery of the different elements of treatment and their effect on outcome. Our aim was to assess the differential effect of type of treatment delivered on the effectiveness of CBT-P, using novel statistical methodology. Method. The Psychological Prevention of Relapse in Psychosis (PRP) trial was a multi-centre randomized controlled trial (RCT) that compared CBT-P with treatment as usual (TAU). Therapy was manualized, and detailed evaluations of therapy delivery and client engagement were made. Follow-up assessments were made at 12 and 24 months. In a planned analysis, we applied principal stratification (involving structural equation modelling with finite mixtures) to estimate intention-to-treat (ITT) effects for subgroups of participants, defined by qualitative and quantitative differences in receipt of therapy, while maintaining the constraints of randomization. Results. Consistent delivery of full therapy, including specific cognitive and behavioural techniques, was associated with clinically and statistically significant increases in months in remission, and decreases in psychotic and affective symptoms. Delivery of partial therapy involving engagement and assessment was not effective. Conclusions. Our analyses suggest that CBT-P is of significant benefit on multiple outcomes to patients able to engage in the full range of therapy procedures. The novel statistical methods illustrated in this report have general application to the evaluation of heterogeneity in the effects of treatment

Changes in serogroup and genotype prevalence among carried meningococci in the United Kingdom during vaccine implementation.

BACKGROUND: Herd immunity is important in the effectiveness of conjugate polysaccharide vaccines against encapsulated bacteria. A large multicenter study investigated the effect of meningococcal serogroup C conjugate vaccine introduction on the meningococcal population. METHODS: Carried meningococci in individuals aged 15-19 years attending education establishments were investigated before and for 2 years after vaccine introduction. Isolates were characterized by multilocus sequence typing, serogroup, and capsular region genotype and changes in phenotypes and genotypes assessed. RESULTS: A total of 8462 meningococci were isolated from 47 765 participants (17.7%). Serogroup prevalence was similar over the 3 years, except for decreases of 80% for serogroup C and 40% for serogroup 29E. Clonal complexes were associated with particular serogroups and their relative proportions fluctuated, with 12 statistically significant changes (6 up, 6 down). The reduction of ST-11 complex serogroup C meningococci was probably due to vaccine introduction. Reasons for a decrease in serogroup 29E ST-254 meningococci (from 1.8% to 0.7%) and an increase in serogroup B ST-213 complex meningococci (from 6.7% to 10.6%) were less clear. CONCLUSIONS: Natural fluctuations in carried meningococcal genotypes and phenotypes a can be affected by the use of conjugate vaccines, and not all of these changes are anticipatable in advance of vaccine introduction