The millisecond pulsar mass distribution: Evidence for bimodality and constraints on the maximum neutron star mass

The mass function of neutron stars (NSs) contains information about the late evolution of massive stars, the supernova explosion mechanism, and the equation-of-state of cold, nuclear matter beyond the nuclear saturation density. A number of recent NS mass measurements in binary millisecond pulsar (MSP) systems increase the fraction of massive NSs (with $M > 1.8$ M$_{\odot}$) to $\sim 20\%$ of the observed population. In light of these results, we employ a Bayesian framework to revisit the MSP mass distribution. We find that a single Gaussian model does not sufficiently describe the observed population. We test alternative empirical models and infer that the MSP mass distribution is strongly asymmetric. The diversity in spin and orbital properties of high-mass NSs suggests that this is most likely not a result of the recycling process, but rather reflects differences in the NS birth masses. The asymmetry is best accounted for by a bimodal distribution with a low mass component centred at $1.393_{-0.029}^{+0.031}$ M$_{\odot}$ and dispersed by $0.064_{-0.025}^{+0.064}$ M$_{\odot}$, and a high-mass component with a mean of $1.807_{-0.132}^{+0.081}$ and a dispersion of $0.177_{-0.072}^{+0.115}$ M$_{\odot}$. We also establish a lower limit of $M_{max} \ge 2.018$ M$_{\odot}$ at 98% C.L. for the maximum NS mass, from the absence of a high-mass truncation in the observed masses. Using our inferred model, we find that the measurement of 350 MSP masses, expected after the conclusion of pulsar surveys with the Square-Kilometre Array, can result in a precise localization of a maximum mass up to 2.15 M$_{\odot}$, with a 5% accuracy. Finally, we identify possible massive NSs within the known pulsar population and discuss birth masses of MSPs.Comment: submitted to ApJ; 21 pages in aastex6 two-column format, 12 figures, 5 tables. Comments are welcom

Discovery and Measurement of Sleptons, Binos, and Winos with a Z'

Extensions of the MSSM could significantly alter its phenomenology at the LHC. We study the case in which the MSSM is extended by an additional U(1) gauge symmetry, which is spontaneously broken at a few TeV. The production cross-section of sleptons is enhanced over that of the MSSM by the process $pp\to Z' \to \tilde{\ell} \tilde{\ell}^*$, so the discovery potential for sleptons is greatly increased. The flavor and charge information in the resulting decay, $\tilde{\ell} \to \ell + {LSP}$, provides a useful handle on the identity of the LSP. With the help of the additional kinematical constraint of an on-shell Z', we implement a novel method to measure all of the superpartner masses involved in this channel. For certain final states with two invisible particles, one can construct kinematic observables bounded above by parent particle masses. We demonstrate how output from one such observable, m_T2, can become input to a second, increasing the number of measurements one can make with a single decay chain. The method presented here represents a new class of observables which could have a much wider range of applicability.Comment: 20 pages, 15 figures; v2 references added and minor change

The Concurrent Engineering Design Paradigm is Now Fully Functional for Graphics Education

Engineering design graphics education has come a long way in the past two decades.  The emergence of solid geometric modeling technology has become the focal point for the graphical development of engineering design ideas.  The main attraction of this 3-D modeling approach is the downstream application of the data base to analysis and manufacturing.  In parallel to this development, our group has been implementing a concurrent engineering design paradigm for engineering graphics education.  Many obstacles to full implementation of this educational paradigm have been encountered.  This paper discusses the two major obstacles, design analysis and low-cost rapid prototyping, that have now been overcome.  Thus it appears that, with current technology, the true long-term goal of “Art to Part” seems to now be fully realizable for engineering graphics education

PCR-based detection of mobile genetic elements in total community DNA

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Long-term efficacy and safety of first-line ibrutinib treatment for patients with CLL/SLL: 5 years of follow-up from the phase 3 RESONATE-2 study.

RESONATE-2 is a phase 3 study of first-line ibrutinib versus chlorambucil in chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Patients aged ≥65 years (n = 269) were randomized 1:1 to once-daily ibrutinib 420 mg continuously or chlorambucil 0.5-0.8 mg/kg for ≤12 cycles. With a median (range) follow-up of 60 months (0.1-66), progression-free survival (PFS) and overall survival (OS) benefits for ibrutinib versus chlorambucil were sustained (PFS estimates at 5 years: 70% vs 12%; HR [95% CI]: 0.146 [0.098-0.218]; OS estimates at 5 years: 83% vs 68%; HR [95% CI]: 0.450 [0.266-0.761]). Ibrutinib benefit was also consistent in patients with high prognostic risk (TP53 mutation, 11q deletion, and/or unmutated IGHV) (PFS: HR [95% CI]: 0.083 [0.047-0.145]; OS: HR [95% CI]: 0.366 [0.181-0.736]). Investigator-assessed overall response rate was 92% with ibrutinib (complete response, 30%; 11% at primary analysis). Common grade ≥3 adverse events (AEs) included neutropenia (13%), pneumonia (12%), hypertension (8%), anemia (7%), and hyponatremia (6%); occurrence of most events as well as discontinuations due to AEs decreased over time. Fifty-eight percent of patients continue to receive ibrutinib. Single-agent ibrutinib demonstrated sustained PFS and OS benefit versus chlorambucil and increased depth of response over time

An Experimentalist's View of Neutrino Oscillations

Neutrinos, and primarily neutrino oscillations, have undoubtedly been one of the most exciting topics in the field of high-energy physics over the past few years. The existence of neutrino oscillations would require an extension of the currently accepted description of sub-nuclear phenomena beyond the Standard Model. Compelling evidence of new physics, which seems to be pointing towards neutrino oscillations, is coming from the solar neutrino deficit and from the atmospheric neutrino anomaly. More controversial effects have been observed with artificially produced neutrinos. The present experimental status of neutrino oscillations is reviewed, as well as the planned future experimental programme, which, it is hoped, will solve most of the outstanding puzzles.Comment: 64 pages, 29 figures, to be published in Intern. J. Mod. Phys. A (2001