199 research outputs found

    Control of MMC-based STATCOM as an effective interface between energy sources and the power grid

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    © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This paper presents a dynamic model of modular multilevel converters (MMCs), which are considered as an effective interface between energy sources and the power grid. By improving the converter performance, appropriate reactive power compensation is guaranteed. Modulation indices are calculated based on detailed harmonic evaluations of both dynamic and steady-state operation modes, which is considered as the main contribution of this paper in comparison with other methods. As another novelty of this paper, circulating current control is accomplished by embedding an additional second harmonic component in the modulation process. The proposed control method leads to an effective reduction in capacitor voltage fluctuation and losses. Finally, converter’s maximum stable operation range is modified, which provides efficiency enhancements and also stability assurance. The proficiency and functionality of the proposed controller are demonstrated through detailed theoretical analysis and simulations with MATLAB/Simulink

    Self-supporting graphene films and their applications

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    The self-supporting monolayer material which is graphene has excited enormous interest over the ten years since its discovery due to its remarkable electrical, mechanical thermal and chemical properties. In this paper we describe our work to develop chemical vapour deposition methods to grow monolayer graphene on copper foil substrates and the subsequent transfer process. Raman microscopy, scanning electron microscopy and atomic force microscopy (AFM) are used to examine the quality of the transferred material. To demonstrate the process we describe transfer onto patterned SiO2/Si substrates which forms freely suspended graphene with focus on circular wells forming graphene drums. These show interesting mechanical properties which are being explored as nanomechanical resonators.UK NMS Programme, the EU EMRP (European Metrology Research Programme) projects MetNEMS and GraphOh

    A VOLTAGE STABILIZER FOR A MICROGRID SYSTEM WITH TWO TYPES OF DISTRIBUTED GENERATION RESOURCES

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    ABSTRACT: Microgrids are used as controllable units connected to power grid, in which the electrical distances between reactive power sources and the loads that need the reactive compensation are not too much. Thus, a coordinated compensation of reactive sources has to be implemented in order to avoid a fast voltage collapse by proposing a Microgrid Voltage Stabilizer (MGVS). This stabilizer is desirable to improve the dynamic voltage profile and is tested at a 21-bus IEEE microgrid system. In order to verify the performance of this stabilizer, three distributed generation (DG) resources are utilized in this microgrid (Two PV resources which are categorized as power-electronic converter based on DG and a diesel generator which is known as synchronous machine-based on DG). At first, the mentioned resources and all of their needed equipments are modeled. Then a control model of the stabilizer with appropriate parameters for the proposed microgrid is presented. Voltage deficiency of the system is the input of the stabilizer, and the output signal of the stabilizer, is divided between the DGs in order to provide required reactive power. The dynamic voltage profile of buses in the presence of MGVS and its absence has been compared by implying disturbances. Simulation results in MATLAB/SIMULINK show that the dynamic voltage profile of the buses improves satisfactorily with the addition of MGVS.   ABSTRAK: Grid mikro digunakan sebagai unit kawalan yang disambungkan kepada grid kuasa, di mana jarak elektrikal antara sumber kuasa reaktif dan bebanan yang memerlukan kompensasi reaktif tidak terlalu besar.  Dengan itu, kompensasi yang selaras dengan sumber reaktif perlu diimplimentasikan untuk mengelak kegagalan voltan pantas dengan menggunakan Grid Mikro Penstabil Voltan (Microgrid Voltage Stabilizer - MGVS). Penstabil ini sesuai digunakan untuk meningkatkan profil voltan dinamik dan telah diuji ke atas sistem mikro grid 21-bus IEEE. Untuk memastikan keupayaan penstabil ini, tiga sumber penjanaan agihan (distributed generation - DG) telah digunakan (dua sumber PV yang dikategorikan sebagai pengubah kuasa elektronik berdasarkan DG dan penjana diesel yang dikenali sebagai mesin segerak berasaskan DG). Mulanya, semua sumber dan alatan yang diperlukan, diilustrasikan. Kemudian, satu model penstabil kawalan bersama parameter yang sesuai dengan mikro grid yang dikemukakan. Ketakcukupan  voltan dalam sistem merupakan input penstabil, isyarat keluaran penstabil kemudiannya dibahagikan antara kesemua DG agar ia dapat menyalurkan kuasa reaktif yang diperlukan. Profil voltan dinamik setiap bus dengan kehadiran MGV dan ketidakhadirannya dibandingkan dengan mengimplikasikan gangguan. Keputusan simulasi menggunakan MATLAB/SIMULINK menunjukkan bahawa profil voltan dinamik setiap bus meningkat pada kadar yang memuaskan dengan kehadiran MGVS

    Microwave study of field-effect devices based on graphene/aluminum nitride/graphene structures

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    Metallic gate electrodes are often employed to control the conductivity of graphene based field effect devices. The lack of transparency of such electrodes in many optical applications is a key limiting factor. We demonstrate a working concept of a double layer graphene field effect device that utilizes a thin film of sputtered aluminum nitride as dielectric gate material. For this system, we show that the graphene resistance can be modified by a voltage between the two graphene layers. We study how a second gate voltage applied to the silicon back gate modifies the measured microwave transport data at around 8.7 GHz. As confirmed by numerical simulations based on the Boltzmann equation, this system resembles a parallel circuit of two graphene layers with different intrinsic doping levels. The obtained experimental results indicate that the graphene-aluminum nitride-graphene device concept presents a promising technology platform for terahertz- to- optical devices as well as radio-frequency acoustic devices where piezoelectricity in aluminum nitride can also be exploited

    Paclitaxel/methotrexate co-loaded PLGA nanoparticles in glioblastoma treatment: Formulation development and in vitro antitumor activity evaluation

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    AimThe aim of this study was to improve the therapeutic index of chemotherapeutic drugs on glioblastoma cells through an improved co-drug delivery system. Materials and methodsMethotrexate (MTX) and paclitaxel (PTX) were co-loaded into poly (lactic-co-glycolic acid) nanoparticles (PLGA NPs) coated with polyvinyl alcohol (PVA) and Poloxamer188 (P188). Key findingsThe mean size of the NPs was about 212 nm, with a zeta potential of about −15.7 mV. Encapsulation efficiency (EE%) and drug loading (DL%) were determined to be 72% and 4% for MTX and 85% and 4.9% for PTX, respectively. The prepared NPs were characterized by differential thermal analysis (DTA) and thermogravimetric analysis (TGA). Moreover, an in vitro sustained release profile was observed for both drug loaded PLGA NPs. Glioblastoma cellular uptake of the NPs was confirmed by fluorescence microscopy and cell survival rate was investigated through the 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method after 48 h of incubation showing IC50 values of 24.5 Όg·mL−1 for PTX and 9.5 Όg·mL−1 for MTX for the MTX/PTX co-loaded PLGA nanoparticles coated with PVA/P188 (Co-2 NPs). Apoptosis and necrosis were also studied via flow cytometry, the lactate dehydrogenase (LDH) assay and the amount of anti-apoptotic protein (Bcl-2) expression. Blood compatibility of the co-delivery of PTX and MTX loaded PLGA NPs was investigated using a hemolysis method as well. SignificanceThe co-delivery of PTX and MTX loaded PLGA NPs is promising for the treatment of glioblastoma compared to their respective free drug formulations and, thus, should be further investigated.This work was supported by Tehran University of Medical Sciences, Grant No. 96-01-87-34138, Iran

    QCD ghost f(T)-gravity model

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    Within the framework of modified teleparallel gravity, we reconstruct a f(T) model corresponding to the QCD ghost dark energy scenario. For a spatially flat FRW universe containing only the pressureless matter, we obtain the time evolution of the torsion scalar T (or the Hubble parameter). Then, we calculate the effective torsion equation of state parameter of the QCD ghost f(T)-gravity model as well as the deceleration parameter of the universe. Furthermore, we fit the model parameters by using the latest observational data including SNeIa, CMB and BAO data. We also check the viability of our model using a cosmographic analysis approach. Moreover, we investigate the validity of the generalized second law (GSL) of gravitational thermodynamics for our model. Finally, we point out the growth rate of matter density perturbation. We conclude that in QCD ghost f(T)-gravity model, the universe begins a matter dominated phase and approaches a de Sitter regime at late times, as expected. Also this model is consistent with current data, passes the cosmographic test, satisfies the GSL and fits the data of the growth factor well as the LCDM model.Comment: 19 pages, 9 figures, 2 tables. arXiv admin note: substantial text overlap with arXiv:1111.726

    Petrographical and geochemical evidences for paragenetic sequence interpretation of diagenesis in mixed siliciclastic–carbonate sediments: Mozduran Formation (Upper Jurassic), south of Agh-Darband, NE Iran

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    The Upper Jurassic Mozduran Formation with a thickness of 420 m at the type locality is the most important gas-bearing reservoir in NE Iran. It is mainly composed of limestone, dolostone with shale and gypsum interbeds that grade into coarser siliciclastics in the easternmost part of the basin. Eight stratigraphic sections were studied in detail in south of the Agh-Darband area. These analyses suggest that four carbonate facies associations and three siliciclastic lithofacies were deposited in shallow marine to shoreline environments, respectively. Cementation, compaction, dissolution, micritization, neomorphism, hematitization, dolomitization and fracturing are diagenetic processes that affected these sediments.Stable isotope variations of ÎŽ18O and ÎŽ13C in carbonate rocks show two different trends. High depletion of ÎŽ18O and low variation of ÎŽ13C probably reflect increasing temperatures during burial diagenesis, while the higher depletion in carbon isotope values with low variations in oxygen isotopes are related to fresh water flushing during meteoric diagenesis. Negative values of carbon isotopes may have also resulted from organic matter alteration during penetration of meteoric water. Fe and Mn enrichment with depletion of ÎŽ18O also supports the contention that alteration associated with higher depletion in carbon isotope values with low variations in oxygen isotopes took place during meteoric diagenesis. The presence of bright luminescence indicates redox conditions during precipitation of calcite cement

    Bianchi {VI}0_{0} in Scalar and Scalar-Tensor Cosmologies

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    We study several cosmological models with Bianchi \textrm{VI}0_{0} symmetries under the self-similar approach. In order to study how the \textquotedblleft constants\textquotedblright\ GG and Λ\Lambda may vary, we propose three scenarios where such constants are considered as time functions. The first model is a perfect fluid. We find that the behavior of GG and Λ\Lambda are related. If GG behaves as a growing time function then Λ\Lambda is a positive decreasing time function but if GG is decreasing then Λ\Lambda is negative. For this model we have found a new solution. The second model is a scalar field, where in a phenomenological way, we consider a modification of the Klein-Gordon equation in order to take into account the variation of GG. Our third scenario is a scalar-tensor model. We find three solutions for this models where GG is growing, constant or decreasing and Λ\Lambda is a positive decreasing function or vanishes. We put special emphasis on calculating the curvature invariants in order to see if the solutions isotropize.Comment: Typos corrected. References added, minor corrections. arXiv admin note: text overlap with arXiv:0905.247

    Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019 : a systematic analysis for the Global Burden of Disease Study 2019

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    Background In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990-2010 time period, with the greatest annualised rate of decline occurring in the 0-9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10-24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10-24 years were also in the top ten in the 25-49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50-74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and development investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve

    Global burden of 87 risk factors in 204 countries and territories, 1990–2019 : a systematic analysis for the Global Burden of Disease Study 2019

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    Background Rigorous analysis of levels and trends in exposure to leading risk factors and quantification of their effect on human health are important to identify where public health is making progress and in which cases current efforts are inadequate. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a standardised and comprehensive assessment of the magnitude of risk factor exposure, relative risk, and attributable burden of disease. Methods GBD 2019 estimated attributable mortality, years of life lost (YLLs), years of life lived with disability (YLDs), and disability-adjusted life-years (DALYs) for 87 risk factors and combinations of risk factors, at the global level, regionally, and for 204 countries and territories. GBD uses a hierarchical list of risk factors so that specific risk factors (eg, sodium intake), and related aggregates (eg, diet quality), are both evaluated. This method has six analytical steps. (1) We included 560 risk-outcome pairs that met criteria for convincing or probable evidence on the basis of research studies. 12 risk-outcome pairs included in GBD 2017 no longer met inclusion criteria and 47 risk-outcome pairs for risks already included in GBD 2017 were added based on new evidence. (2) Relative risks were estimated as a function of exposure based on published systematic reviews, 81 systematic reviews done for GBD 2019, and meta-regression. (3) Levels of exposure in each age-sex-location-year included in the study were estimated based on all available data sources using spatiotemporal Gaussian process regression, DisMod-MR 2.1, a Bayesian meta-regression method, or alternative methods. (4) We determined, from published trials or cohort studies, the level of exposure associated with minimum risk, called the theoretical minimum risk exposure level. (5) Attributable deaths, YLLs, YLDs, and DALYs were computed by multiplying population attributable fractions (PAFs) by the relevant outcome quantity for each age-sex-location-year. (6) PAFs and attributable burden for combinations of risk factors were estimated taking into account mediation of different risk factors through other risk factors. Across all six analytical steps, 30 652 distinct data sources were used in the analysis. Uncertainty in each step of the analysis was propagated into the final estimates of attributable burden. Exposure levels for dichotomous, polytomous, and continuous risk factors were summarised with use of the summary exposure value to facilitate comparisons over time, across location, and across risks. Because the entire time series from 1990 to 2019 has been re-estimated with use of consistent data and methods, these results supersede previously published GBD estimates of attributable burden. Findings The largest declines in risk exposure from 2010 to 2019 were among a set of risks that are strongly linked to social and economic development, including household air pollution; unsafe water, sanitation, and handwashing; and child growth failure. Global declines also occurred for tobacco smoking and lead exposure. The largest increases in risk exposure were for ambient particulate matter pollution, drug use, high fasting plasma glucose, and high body-mass index. In 2019, the leading Level 2 risk factor globally for attributable deaths was high systolic blood pressure, which accounted for 10.8 million (95% uncertainty interval [UI] 9.51-12.1) deaths (19.2% [16.9-21.3] of all deaths in 2019), followed by tobacco (smoked, second-hand, and chewing), which accounted for 8.71 million (8.12-9.31) deaths (15.4% [14.6-16.2] of all deaths in 2019). The leading Level 2 risk factor for attributable DALYs globally in 2019 was child and maternal malnutrition, which largely affects health in the youngest age groups and accounted for 295 million (253-350) DALYs (11.6% [10.3-13.1] of all global DALYs that year). The risk factor burden varied considerably in 2019 between age groups and locations. Among children aged 0-9 years, the three leading detailed risk factors for attributable DALYs were all related to malnutrition. Iron deficiency was the leading risk factor for those aged 10-24 years, alcohol use for those aged 25-49 years, and high systolic blood pressure for those aged 50-74 years and 75 years and older. Interpretation Overall, the record for reducing exposure to harmful risks over the past three decades is poor. Success with reducing smoking and lead exposure through regulatory policy might point the way for a stronger role for public policy on other risks in addition to continued efforts to provide information on risk factor harm to the general public
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