924 research outputs found
Parámetros de Crecimiento y Mortalidad Total de la Dardina Sardinella aurita (Valenciennes,1810) en el Nororiente Venezolano Durante el Período 1990 a 2008. [Resumen extenso]
Elastic electron scattering from 3-hydroxytetrahydrofuran: experimental and theoretical studies
We report the results of measurements and calculations for elastic electron scattering from 3-hydroxytetrahydrofuran (C4H8O2). The measurements are performed with a crossed electron-target beam apparatus and the absolute cross-sections are determined using the relative flow technique. The calculations are carried out using the Schwinger multichannel method in the static-exchange plus polarization (SEP) approximation. A set of angular differential cross-sections (DCS) is provided at five incident energies (6.5, 8, 10, 15 and 20 eV) over an angular range of 20–130°, and the energy dependence of the elastic DCS at a scattering angle of 120° is also presented. Integral elastic and elastic momentum transfer cross-sections have also been derived and calculated. The results are compared with those of recent measurements and calculations for the structurally similar molecule tetrahydrofuran (C4H8O)
Development of in-situ Delayed Hydride Cracking tests using neutron imaging to study the H redistribution in Zr-2.5%Nb
Hydride precipitation and stresses in zircaloy-4 observed by synchrotron X-ray diffraction
The grain stresses within hydrides precipitated in rolled zircaloy-4 plates were determined by synchrotron X-ray diffraction experiments using an 80 keV photon beam and a high-speed area detector placed in transmission geometry. Results showed large compressive stresses (360 ± 20 MPa) in the hydrides along the plate rolling direction. The origin of these stresses was investigated by performing hydride dissolution/precipitation in situ for thermal cycles between room temperature and 400 C. A large stress hysteresis was observed, with a steady decrease on heating and an abrupt change on cooling. The observed stresses are explained by the constraint imposed by grain boundaries on the growth of hydride platelets on the rolling–transverse plane of the rolled plates.Fil: Santisteban, Javier Roberto. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Vicente Alvarez, Miguel Angel. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Vizcaino, Pablo. Comisión Nacional de Energía Atómica. Centro Atómico Ezeiza; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Banchik, A. D.. Comisión Nacional de Energía Atómica. Centro Atómico Ezeiza; ArgentinaFil: Almer, J. D.. No especifíca
Intra-abdominal pulmonary secuestration as an exceptional cause of abdominal mass in the adult
AbstractINTRODUCTIONPulmonary sequestration (PS) is an extremely rare malformation defined as a portion of lung tissue isolated from the pulmonary system. PSs are classified into intralobar type and intra-abdominal PS that represents only 2.5% of cases. There are 20 cases of PS reported in adults and only two were managed by laparoscopic approach. We report a case of intra-abdominal PS mimicking a gastroesophageal duplication cyst in an adult. Besides its rarity, this is the first intra-abdominal PS in an adult managed by an anterior laparoscopic approach.PRESENTATION OF CASEA 60-year-old female patient had had epigastric and left upper quadrant pain for several days. Physical examination was normal. Image test were consistent with a gastroesophageal duplication. The patient was taken to the operating room for laparoscopic exploration and resection. The pathological diagnosis was extralobar pulmonary sequestration.DISCUSSIONLess than 20 cases of PS have been reported in adults and only two cases were managed by a lateral laparoscopic approach. In contrast to these reports, we used an anterior approach due to the GEJ suspected origin of the mass.CONCLUSIONExtralobar intra-abdominal PS is an extremely rare condition during adulthood but this diagnosis should be included in the differential diagnosis of a left-sided suprarenal mass. Due to the difficulty in achieving a definitive preoperative diagnosis, surgery is recommended. Laparoscopic resection is safe and effective but careful preoperative imaging studies are recommended in order to plan the most suitable approach
Effects of peroxisome proliferator-activated receptor- activation in endothelin-dependent hypertension
Aims We analysed the chronic effects of the peroxisome proliferator-activated receptor β/δ (PPAR-β) agonist GW0742 on the renin-independent hypertension induced by deoxycorticosterone acetate (DOCA)-salt.
Methods and results Rats were treated for 5 weeks with: control-vehicle, control-GW0742 (5 or 20 mg kg−1 day−1), DOCA-vehicle, DOCA-GW0742 (5 or 20 mg kg−1 day−1), DOCA-GSK0660 (1 mg kg−1 day−1), and DOCA-GSK0660-GW0742. Rats receiving DOCA-vehicle showed increased systolic blood pressure, left ventricular and kidney weight indices, endothelin-1 (ET-1), and malondialdehyde plasma levels, urinary iso-PGF2α excretion, impaired endothelium-dependent relaxation to acetylcholine, and contraction to ET-1 when compared with controls. Aortic reactive oxygen species content, NADPH oxidase activity, and p47phox, p22phox, NOX-4, glutathione peroxidase 1, hemeoxygenase-1, and preproET-1 expression were increased, whereas catalase and regulators of G protein-coupled signalling proteins (RGS)5 expression were decreased in the DOCA-vehicle group. GW0742 prevented the development of hypertension in a dose-dependent manner but the reduction of renal and cardiac hypertrophy, systemic and vascular oxidative stress markers, and improvement of endothelial dysfunction were only observed after the higher dose. GW0742, at 20 mg kg−1 day−1, attenuated ET-1 contraction by increasing RGS5 expression and restored the intracellular redox balance by reducing NADPH-oxidase activity, and by increasing the antioxidant genes expression. The PPAR-β antagonist GSK0660 prevented all vascular changes induced by GW0742 but not its antihypertensive effects.
Conclusion Vascular protective effects of GW0742 operate via PPAR-β by interference with the ET-1 signalling as a result of increased expression of RGS5 and up-regulation of antioxidant genes and via PPAR-β-independent mechanisms to decrease blood pressure
Optimizing the Parameters Governing the Fragmentation of Cross-Linked Peptides in a Tribrid Mass Spectrometer
We compared the five
different ways of fragmentation available
on a tribrid mass spectrometer and optimized their collision energies
with regard to optimal sequence coverage of cross-linked peptides.
We created a library of bis(sulfosuccinimidyl)suberate (BS3/DSS) cross-linked
precursors, derived from the tryptic digests of three model proteins
(Human Serum Albumin, creatine kinase, and myoglobin). This enabled
in-depth targeted analysis of the fragmentation behavior of 1065 cross-linked
precursors using the five fragmentation techniques: collision-induced
dissociation (CID), beam-type CID (HCD), electron-transfer dissociation
(ETD), and the combinations ETciD and EThcD. EThcD gave the best sequence
coverage for cross-linked <i>m</i>/<i>z</i> species
with high charge density, while HCD was optimal for all others. We
tested the resulting data-dependent decision tree against collision
energy-optimized single methods on two samples of differing complexity
(a mix of eight proteins and a highly complex ribosomal cellular fraction).
For the high complexity sample the decision tree gave the highest
number of identified cross-linked peptide pairs passing a 5% false
discovery rate (on average ∼21% more than the second best,
HCD). For the medium complexity sample, the higher speed of HCD proved
decisive. Currently, acquisition speed plays an important role in
allowing the detection of cross-linked peptides against the background
of linear peptides. Enrichment of cross-linked peptides will reduce
this role and favor methods that provide spectra of higher quality.
Data are available via ProteomeXchange with identifier PXD006131
Electron scattering from molecules and molecular aggregates of biological relevance
In this Topical Review we survey the current state of the art in the study of low energy electron collisions with biologically relevant molecules and molecular clusters. We briefly describe the methods and techniques used in the investigation of these processes and summarise the results obtained so far for DNA constituents and their model compounds, amino acids, peptides and other biomolecules. The applications of the data obtained is briefly described as well as future required developments
Private Financing or Not, That is the Question: Lessons from the Light Rail Systems in Spain
The objective of this paper is to analyze if there
is any difference between the light rail systems in Spain
according to whether they have been carried out through
public financing or private financing (totally or partially).
The importance of this study lies in the fact that, for decades,
the public–private partnership has been proposed as
an alternative to public financing of public transport projects
in order to obtain additional financial resources,
reduce the public deficit, and increase efficiency. However,
there are hardly any detailed studies describing how these
initiatives have turned out. Therefore, the present study
analyzes if there is any difference in the main variables
explaining the performance of light rail projects in Spain
depending on their source of funding can be found. For
this, the relationship between variables related to design,
operation and costs of the projects, and the percentage of
private financing were statistically analyzed. As the most
relevant conclusion, we underline the fact that the investment
per passenger increases when financing is completely
private. This would indicate that the most cost-effective
lines, from a social standpoint, were financed totally or
partially by the public administrations, whereas the least
beneficial ones for society were assigned to private enterprises.
This finding provides an advance in the knowledge
of the consequences of private participation in the financing
of public transport projects, indicating, moreover, that
the biggest beneficiaries of this type of projects might be
the construction companies and the politicians involvedThe authors would like to thank the ERDF of
European Union for financial support via project ‘‘Herramienta para
la evaluacio´n previa de infraestructuras de transporte pu´blico’’
(GGI3003IDIE). We also thank to Public Works Agency and
Regional Ministry of Public Works and Housing of the Regional
Government of Andalusia (AOPJA) and the Ministry of Education,
Culture and Sports of the Government of Spain
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