65,663 research outputs found
Regions of the T cell receptor alpha and beta chains that are responsible for interactions with CD3.
The T cell antigen receptor consists of the Ti alpha/beta heterodimer which recognizes antigen, and the associated CD3 chains, thought to be involved in signal transduction. To understand the nature of the interaction between Ti and CD3, chimeric molecules which included the COOH-terminal segments of Ti alpha or beta linked to the extracellular segment of CD8, were transfected into a mutant T cell deficient in Ti beta chain expression and cell surface CD3. Both chimeric chains were required to express the chimeric Ti and to restore CD3 surface expression. CD8/Ti and CD3 cointernalized and coimmunoprecipitated. Stimulation of the chimeric receptor induced transmembrane signaling events and cell activation. These results demonstrate that the Ti alpha and beta COOH termini containing the transmembrane domains are sufficient for structural and functional coupling of Ti to CD3
A heterotic sigma model with novel target geometry
We construct a (1,2) heterotic sigma model whose target space geometry
consists of a transitive Lie algebroid with complex structure on a Kaehler
manifold. We show that, under certain geometrical and topological conditions,
there are two distinguished topological half--twists of the heterotic sigma
model leading to A and B type half--topological models. Each of these models is
characterized by the usual topological BRST operator, stemming from the
heterotic (0,2) supersymmetry, and a second BRST operator anticommuting with
the former, originating from the (1,0) supersymmetry. These BRST operators
combined in a certain way provide each half--topological model with two
inequivalent BRST structures and, correspondingly, two distinct perturbative
chiral algebras and chiral rings. The latter are studied in detail and
characterized geometrically in terms of Lie algebroid cohomology in the
quasiclassical limit.Comment: 83 pages, no figures, 2 references adde
The influence of atmosphere on the performance of pure-phase WZ and ZB InAs nanowire transistors
We compare the characteristics of phase-pure MOCVD grown ZB and WZ InAs
nanowire transistors in several atmospheres: air, dry pure N and O, and
N bubbled through liquid HO and alcohols to identify whether
phase-related structural/surface differences affect their response. Both WZ and
ZB give poor gate characteristics in dry state. Adsorption of polar species
reduces off-current by 2-3 orders of magnitude, increases on-off ratio and
significantly reduces sub-threshold slope. The key difference is the greater
sensitivity of WZ to low adsorbate level. We attribute this to facet structure
and its influence on the separation between conduction electrons and surface
adsorption sites. We highlight the important role adsorbed species play in
nanowire device characterisation. WZ is commonly thought superior to ZB in InAs
nanowire transistors. We show this is an artefact of the moderate humidity
found in ambient laboratory conditions: WZ and ZB perform equally poorly in the
dry gas limit yet equally well in the wet gas limit. We also highlight the
vital role density-lowering disorder has in improving gate characteristics, be
it stacking faults in mixed-phase WZ or surface adsorbates in pure-phase
nanowires.Comment: Accepted for publication in Nanotechnolog
Tunneling spectroscopy studies of aluminum oxide tunnel barrier layers
We report scanning tunneling microscopy and ballistic electron emission
microscopy studies of the electronic states of the uncovered and
chemisorbed-oxygen covered surface of AlOx tunnel barrier layers. These states
change when chemisorbed oxygen ions are moved into the oxide by either flood
gun electron bombardment or by thermal annealing. The former, if sufficiently
energetic, results in locally well defined conduction band onsets at ~1 V,
while the latter results in a progressively higher local conduction band onset,
exceeding 2.3 V for 500 and 600 C thermal anneals
Observations of HONO by laser-induced fluorescence at the South Pole during ANTCI 2003
Observations of nitrous acid (HONO) by laser-induced fluorescence (LIF) at the South Pole taken during the Antarctic Troposphere Chemistry Investigation (ANTCI), which took place over the time period of Nov. 15, 2003 to Jan. 4, 2004, are presented here. The median observed mixing ratio of HONO 10 m above the snow was 5.8 pptv (mean value 6.3 pptv) with a maximum of 18.2 pptv on Nov 30th, Dec 1st, 3rd, 15th, 17th, 21st, 22nd, 25th, 27th and 28th. The measurement uncertainty is ±35%. The LIF HONO observations are compared to concurrent HONO observations performed by mist chamber/ion chromatography (MC/IC). The HONO levels reported by MC/IC are about 7.2 ± 2.3 times higher than those reported by LIF. Citation: Liao, W., A. T. Case, J. Mastromarino, D. Tan, and J. E. Dibb (2006), Observations of HONO by laser-induced fluorescence at the South Pole during ANTCI 2003, Geophys. Res. Lett., 33, L09810, doi:10.1029/2005GL025470
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