Security oriented e-infrastructures supporting neurological research and clinical trials

The neurological and wider clinical domains stand to gain greatly from the vision of the grid in providing seamless yet secure access to distributed, heterogeneous computational resources and data sets. Whilst a wealth of clinical data exists within local, regional and national healthcare boundaries, access to and usage of these data sets demands that fine grained security is supported and subsequently enforced. This paper explores the security challenges of the e-health domain, focusing in particular on authorization. The context of these explorations is the MRC funded VOTES (Virtual Organisations for Trials and Epidemiological Studies) and the JISC funded GLASS (Glasgow early adoption of Shibboleth project) which are developing Grid infrastructures for clinical trials with case studies in the brain trauma domain

Grid infrastructures for secure access to and use of bioinformatics data: experiences from the BRIDGES project

The BRIDGES project was funded by the UK Department of Trade and Industry (DTI) to address the needs of cardiovascular research scientists investigating the genetic causes of hypertension as part of the Wellcome Trust funded (£4.34M) cardiovascular functional genomics (CFG) project. Security was at the heart of the BRIDGES project and an advanced data and compute grid infrastructure incorporating latest grid authorisation technologies was developed and delivered to the scientists. We outline these grid infrastructures and describe the perceived security requirements at the project start including data classifications and how these evolved throughout the lifetime of the project. The uptake and adoption of the project results are also presented along with the challenges that must be overcome to support the secure exchange of life science data sets. We also present how we will use the BRIDGES experiences in future projects at the National e-Science Centre

Towards a virtual research environment for paediatric endocrinology across Europe

Paediatric endocrinology is a medical specialty dealing with variations of physical growth and sexual development in childhood. Genetic anomalies that can cause disorders of sexual development in children are rare. Given this, sharing and collaboration on the small number of cases that occur is needed by clinical experts in the field. The EU-funded EuroDSD project (www.eurodsd.eu) is one such collaboration involving clinical centres and clinical and genetic experts across Europe. Through the establishment of a virtual research environment (VRE) supporting sharing of data and a variety of clinical and bioinformatics analysis tools, EuroDSD aims to provide a research infrastructure for research into disorders of sex development. Security, ethics and information governance are at the heart of this infrastructure. This paper describes the infrastructure that is being built and the inherent challenges in security, availability and dependability that must be overcome for the enterprise to succeed

Federated authentication and authorisation for e-science

The Grid and Web service community are defining a range of standards for a complete solution for security. The National e-Science Centre (NeSC) at the University of Glasgow is investigating how the various pre-integration components work together in a variety of e-Science projects. The EPSRC-funded nanoCMOS project aims to allow electronics designers and manufacturers to use e-Science technologies and expertise to solve problems of device variability and its impact on system design. To support the security requirements of nanoCMOS, two NeSC projects (VPMan and OMII-SP) are providing tools to allow easy configuration of security infrastructures, exploiting previous successful projects using Shibboleth and PERMIS. This paper presents the model in which these tools interoperate to provide secure and simple access to Grid resources for non-technical users

On the Interpretation of Supernova Light Echo Profiles and Spectra

The light echo systems of historical supernovae in the Milky Way and local group galaxies provide an unprecedented opportunity to reveal the effects of asymmetry on observables, particularly optical spectra. Scattering dust at different locations on the light echo ellipsoid witnesses the supernova from different perspectives and the light consequently scattered towards Earth preserves the shape of line profile variations introduced by asymmetries in the supernova photosphere. However, the interpretation of supernova light echo spectra to date has not involved a detailed consideration of the effects of outburst duration and geometrical scattering modifications due to finite scattering dust filament dimension, inclination, and image point-spread function and spectrograph slit width. In this paper, we explore the implications of these factors and present a framework for future resolved supernova light echo spectra interpretation, and test it against Cas A and SN 1987A light echo spectra. We conclude that the full modeling of the dimensions and orientation of the scattering dust using the observed light echoes at two or more epochs is critical for the correct interpretation of light echo spectra. Indeed, without doing so one might falsely conclude that differences exist when none are actually present.Comment: 18 pages, 22 figures, accepted for publication in Ap

Secure, performance-oriented data management for nanoCMOS electronics

The EPSRC pilot project Meeting the Design Challenges of nanoCMOS Electronics (nanoCMOS) is focused upon delivering a production level e-Infrastructure to meet the challenges facing the semiconductor industry in dealing with the next generation of ‘atomic-scale’ transistor devices. This scale means that previous assumptions on the uniformity of transistor devices in electronics circuit and systems design are no longer valid, and the industry as a whole must deal with variability throughout the design process. Infrastructures to tackle this problem must provide seamless access to very large HPC resources for computationally expensive simulation of statistic ensembles of microscopically varying physical devices, and manage the many hundreds of thousands of files and meta-data associated with these simulations. A key challenge in undertaking this is in protecting the intellectual property associated with the data, simulations and design process as a whole. In this paper we present the nanoCMOS infrastructure and outline an evaluation undertaken on the Storage Resource Broker (SRB) and the Andrew File System (AFS) considering in particular the extent that they meet the performance and security requirements of the nanoCMOS domain. We also describe how metadata management is supported and linked to simulations and results in a scalable and secure manner

Enabling quantitative data analysis through e-infrastructures

This paper discusses how quantitative data analysis in the social sciences can engage with and exploit an e-Infrastructure. We highlight how a number of activities which are central to quantitative data analysis, referred to as ‘data management’, can benefit from e-infrastructure support. We conclude by discussing how these issues are relevant to the DAMES (Data Management through e-Social Science) research Node, an ongoing project that aims to develop e-Infrastructural resources for quantitative data analysis in the social sciences