98 research outputs found

    GĂ©ographie humaine et sociologie

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    Falardeau J.-C. Géographie humaine et sociologie. In: Revue de géographie jointe au Bulletin de la Société de géographie de Lyon et de la région lyonnaise, vol. 25, n°4, 1950. pp. 342-346

    Ecological and Mechanistic Insights Into the Direct and Indirect Antimicrobial Properties of Bacillus subtilis Lipopeptides on Plant Pathogens

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    Members of the genus Bacillus produce a wide variety of antimicrobial compounds. Cyclic lipopeptides (CLP) produced by Bacillus subtilis strains have been shown to protect host plants from a numbers of pathogens. The representative families of these CLP (surfactins, fengycins, and iturins) share a polypeptide ring linked to a lipid tail of varying length. CLP provide plant protection through a variety of unique mechanisms. Members of the surfactin and fengycin families elicit induced systemic resistance in certain host plants, and they also function by directly affecting the biological membranes of bacterial and fungal pathogens, mainly resulting in membrane pore formation. Specific pore forming mechanisms differ between CLP families, causing differential activities. CLP also may aid in enhanced B. subtilis colonization of the plant environment in addition to potentially preventing the adhesion of competitive microorganisms. Several recent studies have highlighted the control of plant pathogens by CLP-producing B. subtilis strains. Strong ecological advantages through multifaceted activities of CLP provide these strains with immense promise in controlling pathogens in a variety of plant ecosystems

    Regional and annual variability in common eider nesting ecology in Labrador

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    Nesting densities are often used to estimate breeding population size and with other measures of reproductive performance can be useful indicators of population status. These aspects of breeding biology often show considerable spatial and temporal variation. Between 2000 and 2003, we surveyed nesting common eiders (Somateria mollissima) on 172 islands in three archipelagos (Nain, Hopedale, Rigolet) on the Labrador coast. Rigolet was the largest archipelago (2834 km2) followed by Nain then Hopedale, and island density varied inversely with archipelago size. Overall means were: nest density 52.0 ± 141.9 (SD) nests/ha; nest initiation 12 June ± 12 days; clutch size 3.7 ± 1.2 eggs/nest; egg volume 98.8 ± 10.4 cm3; and clutch volume 392.3 ± 135.0 cm3. Rigolet had the highest average egg volumes and nest densities, the highest single island nest density of 1053 nests/ha, and the earliest average nest initiation date. We found significant differences in nest densities among archipelagos and across years; significant archipelago and year interactions were detected for nest initiation date and clutch size. Signifi cant differences were found among individual islands for all response variables except egg volume. For egg volume, within-archipelago island differences were not signifi cant, but between-archipelago differences were signifi cant. Thus egg volume may be a useful diagnostic to identify population affi liation

    Cellular lipid composition affects sensitivity of plant pathogens to fengycin, an antifungal compound produced by Bacillus subtilis strain CU12

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    Fengycin is an antimicrobial cyclic lipopeptide produced by various Bacillus subtilis strains, including strain CU12. Direct effects of fengycin include membrane pore formation and efflux of cellular contents leading to cell death in sensitive microorganisms. In this study, four plant pathogens were studied in order to elucidate the role of membrane lipids in their relative sensitivity to fengycin. Inhibition of mycelial growth in these pathogens varied considerably. Analysis of membrane lipids in these microorganisms indicated that sensitivity correlated with low ergosterol content and shorter phospholipid fatty acyl chains. Sensitivity to fengycin also correlated with a lower anionic/zwitterionic phospholipid ratio. Our data suggest that decreased fluidity buffering capacity, as a result of low ergosterol content, and higher intrinsic fluidity afforded by short fatty acyl chain length may increase the sensitivity of microbial membranes to fengycin. Our results also suggest that lower content in anionic phospholipids may increase fengycin insertion into the membrane through reduced electrostatic repulsion with the negatively charged fengycin. The intrinsic membrane lipid composition may contribute, in part, to the observed level of antimicrobial activity of fengycin in various plant pathogens

    Description du fardeau de la dĂ©pression sur la santĂ© de la population au Canada : utilisation de l’espĂ©rance de vie ajustĂ©e en fonction de la santĂ©

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    Introduction : Peu d’études ont Ă©valuĂ©, dans l’ensemble d’une population, les consĂ©quences de la dĂ©pression en matiĂšre de pertes dues Ă  la mortalitĂ© prĂ©maturĂ©e d’une part et Ă  la qualitĂ© de vie liĂ©e Ă  la santĂ© (QVLS) d’autre part. L’espĂ©rance de vie ajustĂ©e en fonction de la santĂ© (EVAS) est une mesure synthĂ©tique de la santĂ© de la population qui combine la morbiditĂ© et la mortalitĂ© en une seule statistique succincte dĂ©crivant l’état de santĂ© d’une population Ă  un moment donnĂ©. MĂ©thodologie : Nous avons estimĂ© la QVLS de la population canadienne adulte en fonction de la prĂ©sence ou non de dĂ©pression. Nous avons effectuĂ© un suivi de la mortalitĂ©, de 1994 Ă  2009, des participants Ă  l’EnquĂȘte nationale sur la santĂ© de la population (ENSP) (n = 12 373) de 20 ans et plus, lĂ  aussi en fonction de la prĂ©sence ou non de dĂ©pression. La dĂ©pression a Ă©tĂ© dĂ©finie comme l’état d’une personne susceptible d’avoir connu au cours de l’annĂ©e prĂ©cĂ©dente un Ă©pisode dĂ©pressif majeur au sens du formulaire abrĂ©gĂ© de l’Entrevue composite diagnostique internationale. L’espĂ©rance de vie a Ă©tĂ© estimĂ©e en crĂ©ant des tables abrĂ©gĂ©es de mortalitĂ© selon le sexe et l’état dĂ©pressif Ă  l’aide des risques relatifs de mortalitĂ© de l’ENSP et des donnĂ©es sur la mortalitĂ© du SystĂšme canadien de surveillance des maladies chroniques (2007 Ă  2009). L’EnquĂȘte sur la santĂ© dans les collectivitĂ©s canadiennes (2009-2010) a fourni des estimations de la prĂ©valence de la dĂ©pression, et l’indice de l’état de santĂ© Health Utilities Index a permis de mesurer la QVLS. L’EVAS de la population adulte a Ă©tĂ© mesurĂ©e en fonction de la prĂ©sence ou non de dĂ©pression et en fonction du sexe Ă  l’aide des estimations combinĂ©es de la mortalitĂ©, de la prĂ©valence de la dĂ©pression et de la QVLS. RĂ©sultats : Chez les femmes ayant connu rĂ©cemment un Ă©pisode de dĂ©pression majeure, l’EVAS Ă  20 ans Ă©tait de 42,0 ans (IC Ă  95 % : 40,2 Ă  43,8), contre 57,0 ans (IC Ă  95 % : 56,8 Ă  57,2) chez les femmes n’ayant pas vĂ©cu rĂ©cemment d’épisode de dĂ©pression majeure. Au sein de la population masculine canadienne, l’EVAS Ă  20 ans Ă©tait de 39,0 ans (IC Ă  95 % : 36,5 Ă  41,5) chez ceux qui avaient connu rĂ©cemment un Ă©pisode de dĂ©pression majeure, contre 53,8 ans (IC Ă  95 % : 53,6 Ă  54,0) chez ceux n’ayant pas connu rĂ©cemment d’épisode de dĂ©pression majeure. La diffĂ©rence de 15 ans dans l’EVAS des femmes avec et sans Ă©pisode rĂ©cent de dĂ©pression majeure peut se dĂ©composer en 12,3 ans attribuables Ă  l’écart de la QVLS et 2,7 ans Ă  l’écart observĂ© en matiĂšre de mortalitĂ©. Les 14,8 annĂ©es de moins d’EVAS chez les hommes ayant souffert de dĂ©pression correspondent Ă  un Ă©cart de la QVLS de 13 ans et Ă  un Ă©cart de mortalitĂ© de 1,8 an. Conclusion : La population canadienne adulte atteinte de dĂ©pression au Canada avait une espĂ©rance de vie en santĂ© considĂ©rablement plus faible que celle ne souffrant pas de dĂ©pression, chez les hommes comme chez les femmes. Si la majeure partie de cet Ă©cart s’explique par des niveaux moins Ă©levĂ©s de la QVLS, la mortalitĂ© prĂ©maturĂ©e joue Ă©galement un rĂŽle

    Describing the population health burden of depression: health-adjusted life expectancy by depression status in Canada

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    Introduction: Few studies have evaluated the impact of depression in terms of losses to both premature mortality and health-related quality of life (HRQOL) on the overall population. Health-adjusted life expectancy (HALE) is a summary measure of population health that combines both morbidity and mortality into a single summary statistic that describes the current health status of a population. Methods: We estimated HALE for the Canadian adult population according to depression status. National Population Health Survey (NPHS) participants 20 years and older (n = 12 373) were followed for mortality outcomes from 1994 to 2009, based on depression status. Depression was defined as having likely experienced a major depressive episode in the previous year as measured by the Composite International Diagnostic Interview Short Form. Life expectancy was estimated by building period abridged life tables by sex and depression status using the relative risks of mortality from the NPHS and mortality data from the Canadian Chronic Disease Surveillance System (2007-2009). The Canadian Community Health Survey (2009/10) provided estimates of depression prevalence and Health Utilities Index as a measure of HRQOL. Using the combined mortality, depression prevalence and HRQOL estimates, HALE was estimated for the adult population according to depression status and by sex. Results: For the population of women with a recent major depressive episode, HALE at 20 years of age was 42.0 years (95% CI: 40.2-43.8) compared to 57.0 years (95% CI: 56.8-57.2) for women without a recent major depressive episode. For the population of Canadian men, HALE at 20 was 39.0 years (95% CI: 36.5-41.5) for those with a recent major depressive episode compared to 53.8 years (95% CI: 53.6-54.0) for those without. For the 15.0-year difference in HALE between women with and without depression, 12.3 years can be attributed to the HRQOL gap and the remaining 2.7 years to the mortality gap. The 14.8 fewer years of HALE observed for men with depression equated to a 13.0-year HRQOL gap and a 1.8-year mortality gap. Conclusion: The population of adult men and women with depression in Canada had substantially lower healthy life expectancy than those without depression. Much of this gap is explained by lower levels of HRQOL, but premature mortality also plays a role
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