2,370 research outputs found
The Atomic and Electronic Structure of Liquid N- Methylformamide as Determined from Diffraction Experiments
The structure of liquid N-methylformamide (NMF) has been investigated using
synchrotron radiation at 77 and 95 keV. The use of high energy photons has
several advantages, in this case especially the large accessible momentum
transfer range, the low absorption and the direct comparability with neutron
diffraction. The range of momentum transfer covered is 0.6 \AA Q
24.0 \AA. Neutron diffraction data on the same sample in the same
momentum transfer range have been published previously. In that study two
differently isotope - substituted species were investigated. In order to
compare neutron and photon diffraction data properly Reverse Monte Carlo (RMC-)
simulations have been performed. Some modifications had to be added to the
standard RMC- code introducing different constraints for inter- and
intramolecular distances as these distances partly overlap in liquid NMF. RMC-
simulations having only the neutron data as input were carried out in order to
test the quality of the X-ray data. The photon structure factor calculated from
the RMC- configurations is found to agree well with the present experimental
data, while it deviates considerably from earlier X-ray work using low energy
photons (17 keV). Finally we discuss whether the different interaction
mechanisms of neutrons and photons can be used to directly access the
electronic structure in the liquid. Evidence is presented that the elastic self
scattering part of liquid NMF is changed with respect to the independent atom
approximation. This modification can be accounted for by a simple charged atoms
model.Comment: Accepted for publication in Molecular Physics, LaTex file, 12 pages,
figures not include
Lower and upper estimates on the excitation threshold for breathers in DNLS lattices
We propose analytical lower and upper estimates on the excitation threshold
for breathers (in the form of spatially localized and time periodic solutions)
in DNLS lattices with power nonlinearity. The estimation depending explicitly
on the lattice parameters, is derived by a combination of a comparison argument
on appropriate lower bounds depending on the frequency of each solution with a
simple and justified heuristic argument. The numerical studies verify that the
analytical estimates can be of particular usefulness, as a simple analytical
detection of the activation energy for breathers in DNLS lattices.Comment: 10 pages, 3 figure
Drosophila SOCS Proteins
The importance of signal transduction cascades such as the EGFR and JAK/STAT pathways for development and homeostasis is highlighted by the high levels of molecular conservation maintained between organisms as evolutionary diverged as fruit flies and humans. This conservation is also mirrored in many of the regulatory mechanisms that control the extent and duration of signalling in vivo. One group of proteins that represent important physiological regulators of both EGFR and JAK/STAT signalling is the members of the SOCS family. Only 3 SOCS-like proteins are encoded by the Drosophila genome, and despite this low complexity, Drosophila SOCS proteins share many similarities to their human homologues. SOCS36E is both a target gene and negative regulator of JAK/STAT signalling while SOCS44A and SOCS36E represent positive and negative regulators of EGFR signalling. Here we review our current understanding of Drosophila SOCS proteins, their roles in vivo, and future approaches to elucidating their functions
Existence of Multistring Solutions of the Self-Gravitating Massive Boson
We consider a semilinear elliptic system which include the model system of
the strings in the cosmology as a special case. We prove existence of
multi-string solutions and obtain precise asymptotic decay estimates near
infinity for the solutions.
As a special case of this result we solve an open problem posed in
\cite{yan}Comment: 12 page
Persistent clinical efficacy and safety of anti-tumour necrosis factor \textgreeka therapy with infliximab in patients with ankylosing spondylitis over 5 years: evidence for different types of response
Background: There is insufficient evidence for the long-term efficacy and safety of anti-tumour necrosis factor therapy in patients with ankylosing spondylitis (AS). This is the first report on the treatment with infliximab over 5 years.Methods: As part of a multicentre randomised trial, 69 patients with active AS at baseline (BL) have been continuously treated with infliximab (5 mg/kg i.v. every 6 weeks)---except for a short discontinuation after 3 years (FU1). The primary outcome of this extension was remission according to the ASsessment in Ankylosing Spondylitis (ASAS) criteria at the end of year 5 of the study (FU2).Results: Of the 43 patients who completed year 3, 42 agreed to continue, 38 of which (90.5%) finished year 5 (55% of 69 initially). Partial clinical remission was achieved in 13 of 38 patients (34.2%) at FU1 and FU2. At FU2, the mean Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) was 2.5±1.9 (BL:6.4, FU1:2.5). BASDAI values <4 were seen in 79% of patients at both, FU1 and FU2. ASAS 20% and 40% responses were seen in 32 (84%) and 24 (63%) patients at FU2, respectively. Most patients classified as non-responders at FU2 were part-time responders, as all but one patient achieved an ASAS 20% response at least once within the last 2 years. Three types of responders were identified. No major side effects occurred during years 4 and 5 of infliximab therapy.Conclusions: Infliximab is safe and efficacious in AS patients over 5 years. The majority of the patients remained on treatment and had rather persistent levels of low disease activity. Different response types could be identified
On the averaging principle for one-frequency systems. Seminorm estimates for the error
We extend some previous results of our work [1] on the error of the averaging
method, in the one-frequency case. The new error estimates apply to any
separating family of seminorms on the space of the actions; they generalize our
previous estimates in terms of the Euclidean norm. For example, one can use the
new approach to get separate error estimates for each action coordinate. An
application to rigid body under damping is presented. In a companion paper [2],
the same method will be applied to the motion of a satellite around an oblate
planet.Comment: LaTeX, 23 pages, 4 figures. The final version published in Nonlinear
Dynamic
Design of a fault tolerant airborne digital computer. Volume 2: Computational requirements and technology
This final report summarizes the work on the design of a fault tolerant digital computer for aircraft. Volume 2 is composed of two parts. Part 1 is concerned with the computational requirements associated with an advanced commercial aircraft. Part 2 reviews the technology that will be available for the implementation of the computer in the 1975-1985 period. With regard to the computation task 26 computations have been categorized according to computational load, memory requirements, criticality, permitted down-time, and the need to save data in order to effect a roll-back. The technology part stresses the impact of large scale integration (LSI) on the realization of logic and memory. Also considered was module interconnection possibilities so as to minimize fault propagation
Far-from-constant mean curvature solutions of Einstein's constraint equations with positive Yamabe metrics
In this article we develop some new existence results for the Einstein
constraint equations using the Lichnerowicz-York conformal rescaling method.
The mean extrinsic curvature is taken to be an arbitrary smooth function
without restrictions on the size of its spatial derivatives, so that it can be
arbitrarily far from constant. The rescaled background metric belongs to the
positive Yamabe class, and the freely specifiable part of the data given by the
traceless-transverse part of the rescaled extrinsic curvature and the matter
fields are taken to be sufficiently small, with the matter energy density not
identically zero. Using topological fixed-point arguments and global barrier
constructions, we then establish existence of solutions to the constraints. Two
recent advances in the analysis of the Einstein constraint equations make this
result possible: A new type of topological fixed-point argument without
smallness conditions on spatial derivatives of the mean extrinsic curvature,
and a new construction of global super-solutions for the Hamiltonian constraint
that is similarly free of such conditions on the mean extrinsic curvature. For
clarity, we present our results only for strong solutions on closed manifolds.
However, our results also hold for weak solutions and for other cases such as
compact manifolds with boundary; these generalizations will appear elsewhere.
The existence results presented here for the Einstein constraints are
apparently the first such results that do not require smallness conditions on
spatial derivatives of the mean extrinsic curvature.Comment: 4 pages, no figures, accepted for publication in Physical Review
Letters. (Abstract shortenned and other minor changes reflecting v4 version
of arXiv:0712.0798
Dynamical large deviations for a boundary driven stochastic lattice gas model with many conserved quantities
We prove the dynamical large deviations for a particle system in which
particles may have different velocities. We assume that we have two infinite
reservoirs of particles at the boundary: this is the so-called boundary driven
process. The dynamics we considered consists of a weakly asymmetric simple
exclusion process with collision among particles having different velocities
- …