Supernatural Agents of the Unconscious Mind: The Gothic Mode in Hamlet and Macbeth

Zadanie pt. „Digitalizacja i udostępnienie w Cyfrowym Repozytorium Uniwersytetu Łódzkiego kolekcji czasopism naukowych wydawanych przez Uniwersytet Łódzki” nr 885/P-DUN/2014 dofinansowane zostało ze środków MNiSW w ramach działalności upowszechniającej nauk

Ritualistic Depositions: The Monarchs’ Death Scenes in Richard II and Henry IV Part Two

Zadanie pt. „Digitalizacja i udostępnienie w Cyfrowym Repozytorium Uniwersytetu Łódzkiego kolekcji czasopism naukowych wydawanych przez Uniwersytet Łódzki” nr 885/P-DUN/2014 dofinansowane zostało ze środków MNiSW w ramach działalności upowszechniającej nauk

Bounds for tentacular Hamiltonians

This paper represents a first step towards the extension of the definition of Rabinowitz Floer homology to non-compact energy hypersurfaces in exact symplectic manifolds. More concretely, we study under which conditions it is possible to establish $L^{\infty}$-bounds for the Floer trajectories of a Hamiltonian with non-compact energy levels. Moreover, we introduce a class of Hamiltonians, called tentacular Hamiltonians, which satisfy the conditions: how to define RFH for these examples will be the subject of a follow-up paper.Comment: typos corrected; readability improve

Prevalence of sleep apnoea in patients with chronic kidney disease (CKD) receiving renal replacement therapy by haemodialysis

Background. Sleep disorders in kidney disease patients occur more frequently than in the general population. Chronic renal disease patients are commonly diagnosed with sleep apnoea syndrome. It occurs in the obstructive, central and mixed form and is of multicausal nature. The aim of the present paper was to assess the frequency of individual types of sleep-related breathing disorders in chronically haemodialysed patients using polysomnography. Material and methods. The study involved stage 5 CKD patients receiving continuous renal replacement therapy by haemodialysis. Results. The obtained results suggest that weight gain between consecutive haemodialysis sessions correlates with more frequent occurrences of disordered breathing events (apnoeas and hypopnoeas) in patients on the night preceding haemodialysis session. Conclusions. Positive linear correlations are observed of systolic and diastolic BP measured before PSG performed on the day before a haemodialysis session with the number of snoring episodes, which might suggest that breathing disorders affect the complex pathogenesis of hypertension in haemodialysed patients

Profilaktyczny program wczesnego rozpoznawania przewlekłej choroby nerek- akcja „Uwaga Nerki”- Bydgoszcz 2010.

Chronic kidney disease (CKD) is a significant health problem in Poland and all over the world. It is estimated that in Poland CKD affects more than 4 million people (it is about 10-13% of the Polish population). Early detection of CKD is of great importance because of the possibility of an effective therapy to protect kidney function especially in patients with high risk of developing CKD. The aim of the study was to analyze the results of the program for early detection of kidney disease conducted in Bydgoszcz in 2010. 347 subjects took part in preventive action of early detection of kidney disease. They underwent free laboratory tests:urinalysis, serum creatinine level, eGFR calculation. Moreover, in each patient’s blood pressure was measured. Besides laboratory tests results, all patients were given comprehensive information concerning further nephrological management. 347 people were evaluated in this local Preventive Program of  Early CKD detection. There were two fold more women than       men. The largest group among the respondents were people aged between 50 and 70 years of age, in stage 2 (63.1%, GFR> 60 ml/min) and 3-stage kidney disease (31.4%, eGFR <60 ml /min).      Przewlekła choroba nerek (PChN) stanowi znaczący problem zdrowotny w Polsce i na świecie. Szacuje się, że w  Polsce na choroby nerek choruje ponad 4 mln osób co stanowi ok. 10-13% społeczeństwa. Wczesne wykrywanie PChN  ma ogromne znaczenie dla możliwości podjęcia skutecznej  terapii, mającej na celu ochronę funkcji nerek zwłaszcza w  grupach wysokiego ryzyka rozwoju PChN.  Celem przedstawionej pracy jest analiza wyników programu wczesnego wykrywania chorób nerek przeprowadzonego na terenie Bydgoszczy w roku 2010. W programie profilaktycznym udział wzięło 347 osób, którym wykonano badanie ogólne moczu, oznaczono stężenie kreatyniny, wyliczono eGFR oraz zmierzono ciśnienie tętnicze. Pacjentom wydano ulotki informacyjne na temat dalszego postępowania po uzyskaniu wyników badań laboratoryjnych. Na badania profilaktyczne zgłosiło się 347 osób, dwukrotnie więcej kobiet niż mężczyzn, najliczniejszą grupę stanowiły osoby w wieku pomiędzy 50 a 70 rokiem życia. Najliczniejszą  grupę stanowili badani w stadium 2 (63,1%, GFR> 60 ml/min)   i w stadium 3 PChN (31.4%, eGFR <60 ml / min).      

Leptin-induced endothelium-dependent vasorelaxation of peripheral arteries in lean and obese rats: role of nitric oxide and hydrogen sulfide.

Published onlineJournal ArticleResearch Support, Non-U.S. Gov'tAdipose tissue hormone leptin induces endothelium-dependent vasorelaxation mediated by nitric oxide (NO) and endothelium-derived hyperpolarizing factors (EDHF). Previously it has been demonstrated that in short-term obesity the NO-dependent and the EDHF-dependent components of vascular effect of leptin are impaired and up-regulated, respectively. Herein we examined the mechanism of the EDHF-dependent vasodilatory effect of leptin and tested the hypothesis that alterations of acute vascular effects of leptin in obesity are accounted for by chronic hyperleptinemia. The study was performed in 5 groups of rats: (1) control, (2) treated with exogenous leptin for 1 week to induce hyperleptinemia, (3) obese, fed highly-palatable diet for 4 weeks, (4) obese treated with pegylated superactive rat leptin receptor antagonist (PEG-SRLA) for 1 week, (5) fed standard chow and treated with PEG-SRLA. Acute effect of leptin on isometric tension of mesenteric artery segments was measured ex vivo. Leptin relaxed phenylephrine-preconstricted vascular segments in NO- and EDHF-dependent manner. The NO-dependent component was impaired and the EDHF-dependent component was increased in the leptin-treated and obese groups and in the latter group both these effects were abolished by PEG-SRLA. The EDHF-dependent vasodilatory effect of leptin was blocked by either the inhibitor of cystathionine γ-lyase, propargylglycine, or a hydrogen sulfide (H2S) scavenger, bismuth (III) subsalicylate. The results indicate that NO deficiency is compensated by the up-regulation of EDHF in obese rats and both effects are accounted for by chronic hyperleptinemia. The EDHF-dependent component of leptin-induced vasorelaxation is mediated, at least partially, by H2S.The study was supported by the EU Project “The equipment of innovative laboratories doing research on new medicines used in the therapy of civilization and neoplastic diseases” within the Operational Program Development of Eastern Poland 2007 - 2013, Priority Axis I Modern Economy, Operations I.3 Innovation Promotion. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Preventive program of early detection of chronic kidney disease. Action “Warning Kidney”- Bydgoszcz 2010.

Chronic kidney disease (CKD) is a significant health problem in Poland and all over the world. It is estimated that in Poland CKD affects more than 4 million people (it is about 10-13% of the Polish population). Early detection of CKD is of great importance because of the possibility of an effective therapy to protect kidney function especially in patients with high risk of developing CKD. The aim of the study was to analyze the results of the program for early detection of kidney disease conducted in Bydgoszcz in 2010. 347 subjects took part in preventive action of early detection of kidney disease. They underwent free laboratory tests:urinalysis, serum creatinine level, eGFR calculation. Moreover, in each patient’s blood pressure was measured. Besides laboratory tests results, all patients were given comprehensive information concerning further nephrological management. 347 people were evaluated in this local Preventive Program of Early CKD detection. There were two fold more women than men. The largest group among the respondents were people aged between 50 and 70 years of age, in stage 2 (63.1%, GFR> 60 ml/min) and 3-stage kidney disease (31.4%, eGFR 60 ml/min) i w stadium 3 PChN (31.4%, eGFR <60 ml / min)

Analysis of the course and treatment of toxocariasis in children—a long-term observation

Toxocariasis is a helminthozoonotic disease caused by ascarid larvae of Toxocara genus: Toxocara canis and Toxocara cati. In the reported study, the clinical course of toxocariasis and administered therapy were evaluated in 103 children. The majority of the children (68.9%) were from the rural environment, with a prevalence of boys (62.1%). At diagnosis of infection, 36 (35%) children reported recurrent abdominal pain, 19 (18.4%) headache, 6 (5.8%) loss of appetite, 2 subfebrile conditions, and 2 arthralgia, Moreover, 23 (22.3%) children demonstrated symptoms of atopic diseases; in 30 (29.1%) children, moderate enlargement of lymphatic nodes was noted. In five children (4.9%), ophthalmic examination revealed unilateral changes in the eye: in two cases retinitis; in one case fibrotic lesions in the vitreous body, complicated 1 year from diagnosis by retinal detachment; and in other children parafoveal lesions and cataract. Only two children with ocular changes at diagnosis reported visual disorders. In 64.3% of children, eosinophilia was observed. A covert form of the disease was diagnosed in 95.1% of the children and an ocular form in 4.9%. In all the children, antiparasitic treatment was implemented, repeated several times in some of them. After therapy, the mean titer of specific antibodies, the number of children with abdominal pains and enlarged lymphatic nodes were decreased, while headaches maintained at unchanged levels. In approximately one fourth of the children with negative results of antibodies after the therapy, the symptoms of the disease were still reported. Evaluation of the efficacy of treatment is not easy due to non-characteristic symptoms and low kinetics of specific anti Toxocara IgG decrease; however, high IgG titers suggest non-effective treatment of concomitant infection requiring subsequent therapy. Due to risk of ocular form, which may develop in any stage of the disease, irrespectively of specific antibodies concentrations, it seems justified to implement antiparasitic treatment in all children infected with T. canis

Częstość występowania bezdechu sennego u pacjentów z przewlekłą chorobą nerek (PChN) leczonych nerkozastępczo hemodializami

Wstęp: Zaburzenia snu występują częściej u pacjentów z chorobami nerek niż w ogólnej populacji. Zespół bezdechu sennego jest częściej diagnozowany u pacjentów z przewlekłą chorobą nerek (PChN). Przybiera on formę obturacyjną, ośrodkową lub mieszaną i ma złożoną etiologię. Celem niniejszej pracy była ocena częstości występowania poszczególnych typów zaburzeń oddychania w trakcie snu przy użyciu polisomnografii u pacjentów długotrwale hemodializowanych. Materiały i metody: Badaniem objęto pacjentów w V stopniu PChN długotrwale leczonych nerkozastępczo metodą hemodializ. Wyniki: Uzyskane wyniki sugerują, że wzrost wagi pacjentów pomiędzy kolejnymi hemodializami koreluje z większą częstością występowania incydentów zaburzeń oddychania w czasie snu (bezdech lub spłycenie oddechu) u pacjentów poddawanych hemodializom. Wnioski: W oparciu o wyniki uzyskane na podstawie przedstawionego badania można wnioskować, że przyrost masy ciała pomiędzy zabiegami hemodializy wiąże się z większą liczbą obserwowanych nieprawidłowych zjawisk oddechowych (bezdechow i spłyceń oddechów) u pacjentów w trakcie nocy poprzedzającej zabieg HD. Ponadto obserwuje się dodatnie korelacje liniowe pomiędzy wartościami RR skurczowego i rozkurczowego zmierzonymi przed badaniem PSG wykonanym w dniu poprzedzającym kolejną hemodializę a liczbą epizodów chrapania, co może sugerować wpływ zaburzeń oddechowych na złożoną patogenezę nadciśnienia tętniczego u chorych hemodializowanych

Common variants of ZNF750, RPTOR and TRAF3IP2 genes and psoriasis risk

Psoriasis vulgaris is a genetically heterogenous disease with unclear molecular background. We assessed the association of psoriasis and its main clinical phenotypes with common variants of three potential psoriasis susceptibility genes: ZNF750, RPTOR and TRAF31P2. We genotyped 10 common variants in a cohort of 1,034 case–control individuals using Taqman genotyping assays and sequencing. Minor alleles of all four TRAF3IP2 variants were more frequent among cases. The strongest, significant association was observed for rs33980500 (OR = 2.5, p = 0.01790). Minor allele of this SNP was always present in two haplotypes found to be associated with increased psoriasis risk: rs13196377_G + rs13190932_G + rs33980500_T + rs13210247_A (OR = 2.7, p = 0.0054) and rs13196377_A + rs13190932_A + rs33980500_T + rs13210247_G (OR = 1.8, p = 0.0008). Analyses of clinically relevant phenotypes revealed association of rs33980500 with pustular psoriasis (OR = 1.2, p = 0.0109). We observed significant connection of severity of cutaneous disease with variation at rs13190932 and suggestive with three remaining TRAF3IP2 SNPs. Another positive associations were found between age of onset and familial aggregation of disease: smoking and younger age of onset, smoking and occurrence of pustular psoriasis, nail involvement and arthropatic psoriasis, nail involvement and more severe course of psoriasis. We found no statistically significant differences in the prevalence of the examined variants of RPTOR and ZNF750 genes among our cases and controls. We have replicated the association of TRAF3IP2-_rs33980500 variant with the susceptibility to psoriasis. We have found new associations with clinically relevant subphenotypes such as pustular psoriasis or moderate-to-severe cases. We ascertain no connection of RPTOR and ZNF750 variants with psoriasis or its subphenotypes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00403-013-1407-9) contains supplementary material, which is available to authorized users