Gain Control With A-Type Potassium Current: IA As A Switch Between Divisive And Subtractive Inhibition

Neurons process and convey information by transforming barrages of synaptic inputs into spiking activity. Synaptic inhibition typically suppresses the output firing activity of a neuron, and is commonly classified as having a subtractive or divisive effect on a neuron’s output firing activity. Subtractive inhibition can narrow the range of inputs that evoke spiking activity by eliminating responses to non-preferred inputs. Divisive inhibition is a form of gain control: it modifies firing rates while preserving the range of inputs that evoke firing activity. Since these two “modes” of inhibition have distinct impacts on neural coding, it is important to understand the biophysical mechanisms that distinguish these response profiles. In this study, we use simulations and mathematical analysis of a neuron model to find the specific conditions (parameter sets) for which inhibitory inputs have subtractive or divisive effects. Significantly, we identify a novel role for the A-type Potassium current (IA). In our model, this fast-activating, slowly-inactivating outward current acts as a switch between subtractive and divisive inhibition. In particular, if IA is strong (large maximal conductance) and fast (activates on a time-scale similar to spike initiation), then inhibition has a subtractive effect on neural firing. In contrast, if IA is weak or insufficiently fast-activating, then inhibition has a divisive effect on neural firing. We explain these findings using dynamical systems methods (plane analysis and fast-slow dissection) to define how a spike threshold condition depends on synaptic inputs and IA. Our findings suggest that neurons can “self-regulate” the gain control effects of inhibition via combinations of synaptic plasticity and/or modulation of the conductance and kinetics of A-type Potassium channels. This novel role for IA would add flexibility to neurons and networks, and may relate to recent observations of divisive inhibitory effects on neurons in the nucleus of the solitary tract

Neural Dynamics in Parkinsonian Brain:The Boundary Between Synchronized and Nonsynchronized Dynamics

Synchronous oscillatory dynamics is frequently observed in the human brain. We analyze the fine temporal structure of phase-locking in a realistic network model and match it with the experimental data from parkinsonian patients. We show that the experimentally observed intermittent synchrony can be generated just by moderately increased coupling strength in the basal ganglia circuits due to the lack of dopamine. Comparison of the experimental and modeling data suggest that brain activity in Parkinson's disease resides in the large boundary region between synchronized and nonsynchronized dynamics. Being on the edge of synchrony may allow for easy formation of transient neuronal assemblies

X-ray Binaries and Globular Clusters in Elliptical Galaxies

The X-ray emission from normal elliptical galaxies has two major components: soft emission from diffuse gas and harder emission from populations of accreting (low-mass) stellar X-ray binaries (LMXB). If LMXB populations are tied to the field stellar populations in galaxies, their total X-ray luminosities should be proportional to the optical luminosities of galaxies. However, recent ASCA and Chandra X-ray observations show that the global luminosities of LMXB components in ellipticals exhibit significant scatter at a given optical luminosity. This scatter may reflect a range of evolutionary stages among LMXB populations in ellipticals of different ages. If so, the ratio of the global LMXB X-ray luminosity to the galactic optical luminosity, L_LMXB/L_opt, may be used to determine when the bulk of stars were formed in individual ellipticals. To test this, we compare variations in L_LMXB/L_opt for LMXB populations in ellipticals to optically-derived estimates of stellar ages in the same galaxies. We find no correlation, implying that L_LMXB/L_opt variations are not good age indicators for ellipticals. Alternatively, LMXBs may be formed primarily in globular clusters (through stellar tidal interactions), rather than in the stellar fields of galaxies. Since elliptical galaxies exhibit a wide range of globular cluster populations for a given galaxian luminosity, this may induce a dispersion in the LMXB populations of ellipticals with similar optical luminosities. Indeed, we find that L_LMXB/L_opt ratios for LMXB populations are strongly correlated with the specific globular cluster frequencies in elliptical galaxies. This suggests that most LMXBs were formed in globular clusters.Comment: 5 pages, emulateapj5 style, 2 embedded EPS figures, to appear in ApJ Letter

Asynchronous response of coupled pacemaker neurons

We study a network model of two conductance-based pacemaker neurons of differing natural frequency, coupled with either mutual excitation or inhibition, and receiving shared random inhibitory synaptic input. The networks may phase-lock spike-to-spike for strong mutual coupling. But the shared input can desynchronize the locked spike-pairs by selectively eliminating the lagging spike or modulating its timing with respect to the leading spike depending on their separation time window. Such loss of synchrony is also found in a large network of sparsely coupled heterogeneous spiking neurons receiving shared input.Comment: 11 pages, 4 figures. To appear in Phys. Rev. Let

Understanding Pound-Drever-Hall locking using voltage controlled radio-frequency oscillators: An undergraduate experiment

We have developed a senior undergraduate experiment that illustrates frequency stabilization techniques using radio-frequency electronics. The primary objective is to frequency stabilize a voltage controlled oscillator to a cavity resonance at 800 MHz using the Pound-Drever-Hall method. This technique is commonly applied to stabilize lasers at optical frequencies. By using only radio-frequency equipment it is possible to systematically study aspects of the technique more thoroughly, inexpensively, and free from eye hazards. Students also learn about modular radio-frequency electronics and basic feedback control loops. By varying the temperature of the resonator, students can determine the thermal expansion coefficients of copper, aluminum, and super invar.Comment: 9 pages, 10 figure

Women Farmers: Pulling Up Their Own Educational Boot Straps with Extension

Women comprise a rapidly growing segment in agriculture. In this article, we examine how a network of women farmers, Extension educators, and researchers responded to the significant increase in women farmers in one state by creating a membership organization that draws on the expertise and resources of the land-grant university and Extension in Pennsylvania to create educational events with networking opportunities. We report 4 years of evaluation data for 37 events indicating educational impact, expansion and enhancement of the network, and marketing strategies for Extension to improve participation of women

Double Neutron Star Systems and Natal Neutron Star Kicks

We study the four double neutron star systems found in the Galactic disk in terms of the orbital characteristics of their immediate progenitors and the natal kicks imparted to neutron stars. Analysis of the effect of the second supernova explosion on the orbital dynamics, combined with recent results from simulations of rapid accretion onto neutron stars lead us to conclude that the observed systems could not have been formed had the explosion been symmetric. Their formation becomes possible if kicks are imparted to the radio-pulsar companions at birth. We identify the constraints imposed on the immediate progenitors of the observed double neutron stars and calculate the ranges within which their binary characteristics (orbital separations and masses of the exploding stars) are restricted. We also study the dependence of these limits on the magnitude of the kick velocity and the time elapsed since the second explosion. For each of the double neutron stars, we derive a minimum kick magnitude required for their formation, and for the two systems in close orbits we find it to exceed 200km/s. Lower limits are also set to the center-of-mass velocities of double neutron stars, and we find them to be consistent with the current proper motion observations.Comment: 25 pages, 6 figs (9 parts), 4 tables, AASTeX, Accepted in Ap

Cortical oxygenation suggests increased effort during cognitive inhibition in ecstasy polydrug users

Background: It is understood that 3,4-methylenedioxymethamphetamine (ecstasy) causes serotonin dysfunction and deficits in executive functioning. When investigating executive function, functional neuroimaging allows the physiological changes underlying these deficits to be investigated. The present study investigated behavioural and brain indices of inhibition in ecstasy-polydrug users. Methods: Twenty ecstasy-polydrug users and 20 drug-naïve participants completed an inhibitory control task (Random Letter Generation (RLG)) while prefrontal haemodynamic response was assessed using functional near infrared spectroscopy (fNIRS). Results: There were no group differences on background measures including sleep quality and mood state. There were also no behavioural differences between the two groups. However, ecstasy-polydrug users displayed significant increases in oxygenated haemoglobin (oxy-Hb) from baseline compared to controls at several voxels relating to areas of the inferior right medial prefrontal cortex, as well the right and left dorsolateral prefrontal cortex. Regression analysis revealed that recency of ecstasy use was a significant predictor of oxy-Hb increase at two voxels over the right hemisphere after controlling for alcohol and cannabis use indices. Conclusion: Ecstasy-polydrug users show increased neuronal activation in the prefrontal cortex compared to non-users. This is taken to be compensatory activation/recruitment of additional resources to attain similar performance levels on the task, which may be reversible with prolonged abstinence

Comparison of surface and column measurements of aerosol scattering properties over the western North Atlantic Ocean at Bermuda

Light scattering by size-resolved aerosols in near-surface air at Tudor Hill, Bermuda, was measured between January and June 2009. Vertical distributions of aerosol backscattering and column-averaged aerosol optical properties were characterized in parallel with a micro-pulse lidar (MPL) and an automated sun–sky radiometer. Comparisons were made between extensive aerosol parameters in the column, such as the lidar-retrieved extinction at 400 m and the aerosol optical depth (AOD), and scattering was measured with a surface nephelometer. Comparisons were also made for intensive parameters such as the Ångström exponent and calculations using AERONET(Aerosol Robotic Network)-derived aerosol physical parameters (size distribution, index of refraction) and Mie theory, and the ratio of submicron scattering to total scattering for size-segregated nephelometer measurements. In these comparisons the <i>r</i>² was generally around 0.50. Data were also evaluated based on back trajectories. The correlation between surface scattering and lidar extinction was highest for flows when the surface scattering was dominated by smaller particles and the flow had a longer footprint over land then over the ocean. The correlation of AOD with surface scatter was similar for all flow regimes. There was also no clear dependence of the atmospheric lapse rate, as determined from a nearby radiosonde station, on flow regime. The Ångström exponent for most flow regimes was 0.9–1.0, but for the case of air originating from North America, but with significant time over the ocean, the Ångström exponent was 0.57 ± 0.18. The submicron fraction of aerosol near the surface (<i>R</i>_sub-surf) was significantly greater for the flows from land (0.66 ± 0.11) than for the flows which spent more time over the ocean (0.40 ± 0.05). When comparing <i>R</i>_sub-surf and the column-integrated submicron scattering fraction, <i>R</i>_sub-col, the correlation was similar, <i>r</i>² = 0.50, but <i>R</i>_sub-surf was generally less than <i>R</i>_sub-col, indicating more large particles contributing to light scattering at the surface, contrary to conditions over continents and for polluted continental transport over the ocean. In general, though, the marginal correlations indicate that the column optical properties are weakly correlated with the surface optical measurements. Thus, if it is desired to associate aerosol chemical/physical properties with their optical properties, it is best to use optical and chemical/physical measurements with both collected at the surface or both collected in the column