Maternal urinary metabolic signatures of fetal growth and associated clinical and environmental factors in the INMA study

Background Maternal metabolism during pregnancy is a major determinant of the intra-uterine environment and fetal outcomes. Herein, we characterize the maternal urinary metabolome throughout pregnancy to identify maternal metabolic signatures of fetal growth in two subcohorts and explain potential sources of variation in metabolic profiles based on lifestyle and clinical data. Methods We used 1H nuclear magnetic resonance (NMR) spectroscopy to characterize maternal urine samples collected in the INMA birth cohort at the first (n = 412 and n = 394, respectively, in Gipuzkoa and Sabadell cohorts) and third trimesters of gestation (n = 417 and 469). Metabolic phenotypes that reflected longitudinal intra- and inter-individual variation were used to predict measures of fetal growth and birth weight. Results A metabolic shift between the first and third trimesters of gestation was characterized by 1H NMR signals arising predominantly from steroid by-products. We identified 10 significant and reproducible metabolic associations in the third trimester with estimated fetal, birth, and placental weight in two independent subcohorts. These included branched-chain amino acids; isoleucine, valine, leucine, alanine and 3 hydroxyisobutyrate (metabolite of valine), which were associated with a significant fetal weight increase at week 34 of up to 2.4 % in Gipuzkoa (P < 0.005) and 1 % in Sabadell (P < 0.05). Other metabolites included pregnancy-related hormone by-products of estrogens and progesterone, and the methyl donor choline. We could explain a total of 48–53 % of the total variance in birth weight of which urine metabolites had an independent predictive power of 12 % adjusting for all other lifestyle/clinical factors. First trimester metabolic phenotypes could not predict reproducibly weight at later stages of development. Physical activity, as well as other modifiable lifestyle/clinical factors, such as coffee consumption, vitamin D intake, and smoking, were identified as potential sources of metabolic variation during pregnancy. Conclusions Significant reproducible maternal urinary metabolic signatures of fetal growth and birth weight are identified for the first time and linked to modifiable lifestyle factors. This novel approach to prenatal screening, combining multiple risk factors, present a great opportunity to personalize pregnancy management and reduce newborn disease risk in later life

Estat de conservació de les praderies de Posidonia oceanica (Linnaeus) Delile, 1813 dins la Badia de Portocolom (Mallorca)

&#091;cat&#093; Posidonia oceanica (Linnaeus), Delile, 1813 és una fanerògama marina endèmica del Mediterrani que proporciona gran quantitat de serveis ecosistèmics i és clau per a la conservació de la biodiversitat. Com la majoria de la vegetació marina està en greu recessió. Una de les principals amenaces que afecten aquesta planta, juntament amb l’eutrofització i l’escalfament global, és el fondeig incontrolat. En aquest estudi fem una avaluació de l’estat de conservació de la praderia de P. oceanica situada davant la platja de s’Arenal a la badia de Portocolom afectada per fondeig incontrolat. La mitjana del percentatge de cobertura entre una fondària de 2 i 4.8 metres va ser de 44.2 ± 13.6 %, cobertures inferiors a les reportades anteriorment per aquesta zona. Les densitats van variar entre 392 i 576 feixos/m2, amb una mitjana de 508 ± 31 feixos/m2. Aquesta praderia té molt baixa densitat, o densitat anormal, indicant que està sotmesa a pressions que posen en perill el seu estat de conservació. Vam poder estimar el nombre de feixos arrabassats per una àncora d’un vaixell d’uns 15 metres d’eslora, que va ser de 165 ± 31 feixos. Aquesta praderia necessitaria 5 anys en condicions òptimes per poder recolonitzar l’àrea arrabassada per aquesta àncora. Una estima del carboni alliberat per l’efecte del fondeig d’aquesta àncora revelaria que 915 g de carboni quedaria disponible i podria ser alliberat a l’atmosfera.&#091;eng&#093; Posidonia oceanica (Linnaeus), Delile, 1813 is an endemic Mediterranean seagrass that provides multiple ecosystem services and is a key species for biodiversity conservation. Like most submerged vegetation, this key habitat is regressing alarmingly. One of the main threats affecting this seagrass, together with eutrophication and global warming, is uncontrolled anchoring. Here, we evaluate the conservation status of the P. oceanica meadow in front of s’Arenal beach in Portocolom Bay that is affected by uncontrolled anchoring. The mean cover percentage at depths between 2 and 4.8 meters was 44.2 ± 13.6 %, lower than previously reported for this area. Densities varied between 392 and 576 shoots/m2, with an average of 508 ± 31 shoots/m2. This is a very low, or even an abnormal, density, indicating that this meadow is subject to pressures that are threatening its conservation. We could estimate the number of shoots that were torn off by the action of anchoring of a 15 m long boat: 165 ± 31 shoots. This meadow would require 5 years of optimal conditions to be able to recolonize the area removed by the action of this anchoring. An estimate of the carbon released by the action of this anchoring was 915 g of carbon that could become available and could be released to the atmosphere

Matrix controlled channel diffusion of sodium in amorphous silica

To find the origin of the diffusion channels observed in sodium-silicate glasses, we have performed classical molecular dynamics simulations of Na$_2$O--4SiO$_2$ during which the mass of the Si and O atoms has been multiplied by a tuning coefficient. We observe that the channels disappear and that the diffusive motion of the sodium atoms vanishes if this coefficient is larger than a threshold value. Above this threshold the vibrational states of the matrix are not compatible with those of the sodium ions. We interpret hence the decrease of the diffusion by the absence of resonance conditions.Comment: 5 pages, 4 figure

An international prospective general population-based study of respiratory work disability

Background: Previous cross-sectional studies have shown that job change due to breathing problems at the workplace (respiratory work disability) is common among adults of working age. That research indicated that occupational exposure to gases, dust and fumes was associated with job change due to breathing problems, although causal inferences have been tempered by the cross-sectional nature of previously available data. There is a need for general population-based prospective studies to assess the incidence of respiratory work disability and to delineate better the roles of potential predictors of respiratory work disability.Methods: A prospective general population cohort study was performed in 25 centres in 11 European countries and one centre in the USA. A longitudinal analysis was undertaken of the European Community Respiratory Health Survey including all participants employed at any point since the baseline survey, 6659 subjects randomly sampled and 779 subjects comprising all subjects reporting physician-diagnosed asthma. The main outcome measure was new-onset respiratory work disability, defined as a reported job change during follow-up attributed to breathing problems. Exposure to dusts (biological or mineral), gases or fumes during follow-up was recorded using a job-exposure matrix. Cox proportional hazard regression modelling was used to analyse such exposure as a predictor of time until job change due to breathing problems.Results: The incidence rate of respiratory work disability was 1.2/1000 person-years of observation in the random sample (95% CI 1.0 to 1.5) and 5.7/1000 person-years in the asthma cohort (95% CI 4.1 to 7.8). In the random population sample, as well as in the asthma cohort, high occupational exposure to biological dust, mineral dust or gases or fumes predicted increased risk of respiratory work disability. In the random sample, sex was not associated with increased risk of work disability while, in the asthma cohort, female sex was associated with an increased disability risk (hazard ratio 2.8, 95% CI 1.3 to 5.9).Conclusions: Respiratory work disability is common overall. It is associated with workplace exposures that could be controlled through preventive measures

From lean production to lean 4.0: a systematic literature review with a historical perspective

Over recent decades, the increasing competitiveness of markets has propagated the term “lean” to describe the management concept for improving productivity, quality, and lead time in industrial as well as services operations. Its overuse and linkage to different specifiers (surnames) have created confusion and misunderstanding as the term approximates pragmatic ambiguity. Through a systematic literature review, this study takes a historical perspective to analyze 4962 papers and 20 seminal books in order to clarify the origin, evolution, and diversification of the lean concept. Our main contribution lies in identifying 17 specifiers for the term “lean” and proposing four mechanisms to explain this diversification. Our research results are useful to both academics and practitioners to return to the Lean origins in order to create new research areas and conduct organizational transformations based on solid concepts. We conclude that the use of “lean” as a systemic thinking is likely to be further extended to new research fields