2,068 research outputs found
Two insects injurious to the strawberry
Caption title.Also continuously numbered from the previous Bulletin (p. 189-210) on upper outside corner.The strawberry false-worm : Harpiphorus maculatus, Nort. -- The common strawberry leaf-roller : Phoxopteris comptana, Frohl
Innate immune receptor NOD2 mediates LGR5+ intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation
International audienceThe nucleotide-binding oligomerization domain-containing protein 2 (NOD2) agonist muramyl dipeptide (MDP), a peptidoglycan motif common to all bacteria, supports leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5)+ intestinal stem cell (ISC) survival through NOD2 activation upon an otherwise lethal oxidative stress-mediated signal. However, the underlying protective mechanisms remain unknown. Here, using irradiation as stressor and primarily murine-derived intestinal organoids as a model system, we show that MDP induced a significant reduction of total and mitochondrial reactive oxygen species (ROS) within ISCs, which was associated with mitophagy induction. ATG16L1 knockout (KO) and NOD2 KO organoids did not benefit from the MDP-induced cytoprotection. We confirmed the MDP-dependent induction of ISC mitophagy upon stress in vivo. These findings elucidate the NOD2-mediated mechanism of cytoprotection involving the clearance of the lethal excess of ROS molecules through mitophagy, triggered by the coordinated activation of NOD2 and ATG16L1 by a nuclear factor ÎşB (NF-ÎşB)-independent pathway
A 1.82 m^2 ring laser gyroscope for nano-rotational motion sensing
We present a fully active-controlled He-Ne ring laser gyroscope, operating in
square cavity 1.35 m in side. The apparatus is designed to provide a very low
mechanical and thermal drift of the ring cavity geometry and is conceived to be
operative in two different orientations of the laser plane, in order to detect
rotations around the vertical or the horizontal direction. Since June 2010 the
system is active inside the Virgo interferometer central area with the aim of
performing high sensitivity measurements of environmental rotational noise. So
far, continuous not attempted operation of the gyroscope has been longer than
30 days. The main characteristics of the laser, the active remote-controlled
stabilization systems and the data acquisition techniques are presented. An
off-line data processing, supported by a simple model of the sensor, is shown
to improve the effective long term stability. A rotational sensitivity at the
level of ten nanoradiants per squareroot of Hz below 1 Hz, very close to the
required specification for the improvement of the Virgo suspension control
system, is demonstrated for the configuration where the laser plane is
horizontal
The chinch bug : Blissus leucopterus, Say.
Cover title.Also continuously numbered from previous Bulletin (p. 118-142) on upper outside corner
Hessian fly in Missouri
Cover title.Also continuously numbered from previous Bulletin (p. 131-149) on upper outside corner
- …