26 research outputs found
Beam-Normal Single Spin Asymmetry in Elastic Electron Scattering off Si and Zr
We report on a new measurement of the beam-normal single spin asymmetry
in the elastic scattering of 570 MeV transversely polarized
electrons off Si and Zr at . The
studied kinematics allow for a comprehensive comparison with former results on
C. No significant mass dependence of the beam-normal single spin
asymmetry is observed in the mass regime from C to Zr.Comment: Submitted for publication to Physics Letters
Comparison of recoil polarization in the process for protons extracted from and shell
We present first measurements of the double ratio of the polarization
transfer components for knock-out protons from and
shells in measured by the reaction in quasi-elastic kinematics. The data are
compared to theoretical predictions in relativistic distorted-wave impulse
approximation. Our results show that differences between - and -shell
protons, observed when compared at the same initial momentum (missing momentum)
largely disappear when the comparison is done at the same proton virtuality. We
observe no density-dependent medium modifications for protons from and
shells with the same virtuality in spite of the large differences in the
respective nuclear densities
Decidual stromal cells support tolerance at the human foetal-maternal interface by inducing regulatory M2 macrophages and regulatory T-cells
During pregnancy, the semi-allogeneic nature of the foetus requires maternal immune adaption and acquisition of tolerance at the foetal-maternal interface. Macrophages with regulatory properties and regulatory T (Treg) cells are central in promoting foetal tolerance and are enriched in the decidua (the uterine endometrium during pregnancy). Although tissue-resident decidual stromal cells (DSC) have been implicated in regulatory functions, it is not known if they are able to induce the regulatory phenotype of macrophages and T-cells. In this study we report that maternally derived DSC are able to induce homeostatic M2 macrophages and Treg cells. CD14+ monocytes and CD4+ T-cells from healthy non-pregnant women were cultured in the presence or absence of conditioned medium (CM) from DSC isolated from 1st trimester and term placentas. DSC-CM alone was able to promote the survival of macrophages and to induce a regulatory CD14brightCD163+CD209+CD86dim phenotype, typical for decidual macrophages and similar to that induced by M-CSF. Interestingly, DSC-CM was also able to overrule the pro-inflammatory effects of GM-CSF by upregulating CD14, CD163 and CD209. Protein-profiling showed that M-CSF was secreted by DSC, and blocking of M-CSF partially reversed the M2 phenotype and reduced viability. DSC-CM also expanded CD25brightFoxp3+ Treg cells, an expansion that was abolished by a SMAD3-inhibitor, indicating the contribution of TGF-beta signaling. In conclusion, our findings collectively emphasize the role of tissue-resident stromal cells in shaping the tolerogenic environment at the foetal-maternal interface.Funding Agencies|Swedish Research CouncilSwedish Research CouncilEuropean Commission [201901311, 201802776]; Medical Research Council of Southeast SwedenUK Research & Innovation (UKRI)Medical Research Council UK (MRC); ALF grants; Linkodping University; Cancer Society in Stockholm [141193]; Swedish Cancer Foundation [CAN 2014/793]; Swedish Childhood Cancer FoundationEuropean Commission [PR2015-0059]; Karolinska InstitutetKarolinska Institutet</p
Immediacy and distance in teacher talk—A comparative case study in German elementary- and outdoor school-teaching
A highly segmented neutron polarimeter for A1
International audienceA new neutron polarimeter for measuring the neutron’s electric form factor was designed and constructed to complement the A1 spectrometer setup at the Mainz Microtron (MAMI). The design is based on a previous polarimeter with significant improvements to halve the error of the extracted form factor. A higher granularity of the polarimeter sections and a deeper first section on the one hand, and a faster readout employing Time-over-Threshold methods to measure the signal amplitudes combined with a high-precision FPGA-based TDC on the other hand will allow to achieve this goal. The performance of the new polarimeter during a first measurement campaign in 2019 using liquid hydrogen and deuterium targets will be discussed