Autologous platelet scintigraphy and clinical outcome of splenectomy in immune thrombocytopenia:A systematic review and meta-analysis

Autologous platelet sequestration pattern is associated with post-splenectomy platelet response in patients with immune thrombocytopenia (ITP). However, published results are contradictory, and have not been systematically reviewed. Our aim is to systematically review and meta-analyse the association between sequestration pattern and post-splenectomy platelet response. Articles were selected from MEDLINE when they a) included ITP patients, b) performed scintigraphy, and c) included post-splenectomy platelet response. The 23 included studies (published between 1969-2018) represented 2966 ITP-patients. Response to splenectomy occurred most frequently in patients with a splenic pattern (87.1 % in splenic versus 47.1 % in mixed and 25.5 % in hepatic patterns). A pooled analysis of 8 studies showed an odds ratio of 14.21 (95 % CI: 3.65-55.37) for platelet response in the splenic versus the hepatic group. Our findings indicate that a splenic sequestration pattern is associated with better response after splenectomy. Platelet sequestration patterns may be useful in the clinical decision-making regarding splenectomy.Immunobiology of allogeneic stem cell transplantation and immunotherapy of hematological disease

Understanding the influence of farmer motivations on changes to soil erosion risk on sites of former serious erosion in the South Downs National Park, UK

Serious soil erosion occurred in the South Downs National Park, southern England in the years 1982–2006 and details of around 400 sites are contained in a database. In 2010 we revisited 85 of the most serious sites where erosion of >10 m3 ha−1 y−1 had been recorded in order to assess land use change and any conservation measures undertaken. At 79% of the sites land use change had resulted in a reduction in the risk of erosion, most notably at 28 sites with a shift to permanent grass from winter cereals. At only 21% of sites was the risk of erosion unchanged. Twenty two farmers responsible for 66 of the sites were interviewed. Land management practices had changed on all of the fields of interest to this study since the time of the serious erosion events, to those which have the potential to lower soil erosion risk. Sixteen interviewees claimed that erosion was a motivating reason for changing their practices, due to either experiencing on or on- and off-farm impacts firsthand (12), having knowledge or suspicion of serious erosion having occurred on their land prior to their management (three), or having no knowledge of any serious erosion on their land but just wanting to reduce overall erosion risk (one). Amongst the main changes reported are changes of land use from winter cereals to grass or to overwinter stubble which have undoubtedly reduced the risk of erosion. However, some changed practices claimed by farmers, such as along-the-contour-working, earlier sowing and the use of rollers may be of little value. Furthermore, deeper analysis of farmers’ motivations regarding changes in land management practices suggests a complex picture in which a range of socio-economic influences come into play over time including financial incentives offered by agri-environmental schemes which were found to be an important driver of change. Future changes in farming economics may therefore undermine the reduction in erosion risk in the longer term

The Paradox of Engagement: Land Stewardship and Invasive Weeds in Amenity Landscapes

In New South Wales, Australia, rural landscapes are undergoing profound change as a result of exurbanization. Newcomers-amenity migrants-are drawn to the scenic beaches, forests, and open landscape character of this part of Australia near Sydney and they join existing communities of long-term residents, notably ranchers involved in dairy, beef, and other types of primary agricultural production. The rural to exurban transition is stimulating both intended and unintended socio-ecological changes, especially the proliferation of invasive weeds, which are considered to be a top national priority as they threaten Australia\u27s agricultural economy. Drawing on interview and survey research from three case studies in New South Wales, locations where an influx of exurbanites has led to mixed landscapes of production and consumption, we explore landowners\u27 diverse environmental ideologies, the degree to which they collaborate with one another, and their specific land-use practices. Results show that an overwhelming majority of both exurbanites and ranchers express concerns about weeds, but there is a marked lack of coordinated engagement on invasive species between the two types of groups. This chapter is an example of social disengagement over land-use and land-cover change, rather than competition or cooperation, and contributes to a political ecological understanding of the co-construction of social relations and land management regimes

The role of Landcare group networks in rural Australia : exploring the contribution of social capital

In this paper, the authors report their qualitative research examining the origins, modus operandi and outcomes of two networks. The concept of social capital explains, at least in part, the apparent success of these networks. The two networks attracted substantial funding, created opportunities for participation and shared learning, carried out extensive on-ground works, improved communication structures, adopted more professional management practices and increased the knowledge of members. The key elements of social capital that were important in achieving these outcomes were trust, norms, expectations of reciprocity and linkages. Empowerment acted as a bridge that linked social capital with other factors contributing to network outcomes. The success of these Landcare networks suggests that top-down government stimulus can be a catalyst for bottom-up community development

The role of Landcare group networks in rural Australia : exploring the contribution of social capital

In this paper, the authors report their qualitative research examining the origins, modus operandi and outcomes of two networks. The concept of social capital explains, at least in part, the apparent success of these networks. The two networks attracted substantial funding, created opportunities for participation and shared learning, carried out extensive on-ground works, improved communication structures, adopted more professional management practices and increased the knowledge of members. The key elements of social capital that were important in achieving these outcomes were trust, norms, expectations of reciprocity and linkages. Empowerment acted as a bridge that linked social capital with other factors contributing to network outcomes. The success of these Landcare networks suggests that top-down government stimulus can be a catalyst for bottom-up community development

Autologous platelet scintigraphy and clinical outcome of splenectomy in immune thrombocytopenia:A systematic review and meta-analysis

Autologous platelet sequestration pattern is associated with post-splenectomy platelet response in patients with immune thrombocytopenia (ITP). However, published results are contradictory, and have not been systematically reviewed. Our aim is to systematically review and meta-analyse the association between sequestration pattern and post-splenectomy platelet response. Articles were selected from MEDLINE when they a) included ITP patients, b) performed scintigraphy, and c) included post-splenectomy platelet response. The 23 included studies (published between 1969-2018) represented 2966 ITP-patients. Response to splenectomy occurred most frequently in patients with a splenic pattern (87.1 % in splenic versus 47.1 % in mixed and 25.5 % in hepatic patterns). A pooled analysis of 8 studies showed an odds ratio of 14.21 (95 % CI: 3.65-55.37) for platelet response in the splenic versus the hepatic group. Our findings indicate that a splenic sequestration pattern is associated with better response after splenectomy. Platelet sequestration patterns may be useful in the clinical decision-making regarding splenectomy.</p

Research into the long-term physical implications of net overseas migration: Australia in 2050

Full Report: Research into the long-term physical implications of Net Overseas Migration July 2010, Department of Immigration and Citizenship, National Institute of Labour Studies, Flinders University and CSIRO Sustainable EcosystemsJonathan Sobels, Sue Richardson, Graham Turner, Alaric Maude, Yan Tan, Andrew Beer and Zhang Weihttp://www.immi.gov.au/media/publications/research