Using a cognitive architecture to examine what develops

Different theories of development propose alternative mechanisms by which development occurs. Cognitive architectures can be used to examine the influence of each proposed mechanism of development while keeping all other mechanisms constant. An ACT-R computational model that matched adult behavior in solving a 21-block pyramid puzzle was created. The model was modified in three ways that corresponded to mechanisms of development proposed by developmental theories. The results showed that all the modifications (two of capacity and one of strategy choice) could approximate the behavior of 7-year-old children on the task. The strategy-choice modification provided the closest match on the two central measures of task behavior (time taken per layer, r = .99, and construction attempts per layer, r = .73). Modifying cognitive architectures is a fruitful way to compare and test potential developmental mechanisms, and can therefore help in specifying “what develops.

A Microscopic Energy- and Density-Dependent Effective Interaction and its Test by Nucleus-Nucleus Scattering

An effective nucleon-nucleon interaction calculated in nuclear matter from the Bonn potential has been parametrized in terms of a local density- and energy-dependent two-body interaction. This allows to calculate the real part of the nucleus-nucleus scattering potential and to test this effective interaction over a wide region of densities ($\rho \leq 3\rho_0$) produced dynamically in scattering experiments. Comparing our calculations with empirical potentials extracted from data on light and heavy ion scattering by model-unrestricted analysis methods, we find quantitative agreement with the exception of proton scattering. The failure in this case may be traced back to the properties of the effective interaction at low densities, for which the nuclear matter results are not reliable. The success of the interaction at high overlap densities confirms the empirical evidence for a soft equation of state for cold nuclear matter.Comment: 8 pages 3 Figures included, to appear in Phys. Lett.

Perspectives of vets on plastics in veterinary medicine

The use of disposable plastics and their subsequent environmental impacts are topics of increasing concern in modern society. Medical, including veterinary, sectors are major contributors to plastic waste production. While there is an existing body of literature on the use and reduction of disposable plastics in the human medical sector, few studies, if any, have specifically investigated the use of plastics within the veterinary field. The overall aim of this pilot study was to investigate Australian veterinarians regarding their attitudes toward the ways in which they use disposable plastic in their work and personal lives

Not Alone: Tracing the Origins of Very Low Mass Stars and Brown Dwarfs Through Multiplicity Studies

The properties of multiple stellar systems have long provided important empirical constraints for star formation theories, enabling (along with several other lines of evidence) a concrete, qualitative picture of the birth and early evolution of normal stars. At very low masses (VLM; M <~ 0.1 M_sun), down to and below the hydrogen burning minimum mass, our understanding of formation processes is not as clear, with several competing theories now under consideration. One means of testing these theories is through the empirical characterization of VLM multiple systems. Here, we review the results of various VLM multiplicity studies to date. These systems can be generally characterized as closely separated (93% have projected separations Delta < 20 AU) and near equal-mass (77% have M_2/M_1 >= 0.8) occurring infrequently (perhaps 10-30%). Both the frequency and maximum separation of stellar and brown dwarf binaries steadily decrease for lower system masses, suggesting that VLM binary formation and/or evolution may be a mass-dependent process. There is evidence for a fairly rapid decline in the number of loosely-bound systems below ~0.3 M_sun, corresponding to a factor of 10-20 increase in the minimum binding energy of VLM binaries as compared to more massive stellar binaries. This wide-separation ``desert'' is present among both field (~1-5 Gyr) and older (> 100 Myr) cluster systems, while the youngest (<~10 Myr) VLM binaries, particularly those in nearby, low-density star forming regions, appear to have somewhat different systemic properties. We compare these empirical trends to predictions laid out by current formation theories, and outline future observational studies needed to probe the full parameter space of the lowest mass multiple systems.Comment: 16 pages, 7 figures, contributed chapter for Planets and Protostars V meeting (October 2005); full table of VLM binaries can be obtained at http://paperclip.as.arizona.edu/~nsiegler/VLM_binarie

Discovery of a 66 mas Ultracool Binary with Laser Guide Star Adaptive Optics

We present the discovery of 2MASS J21321145+1341584AB as a closely separated (0.066") very low-mass field dwarf binary resolved in the near-infrared by the Keck II Telescope using laser guide star adaptive optics. Physical association is deduced from the angular proximity of the components and constraints on their common proper motion. We have obtained a near-infrared spectrum of the binary and find that it is best described by an L5+/-0.5 primary and an L7.5+/-0.5 secondary. Model-dependent masses predict that the two components straddle the hydrogen burning limit threshold with the primary likely stellar and the secondary likely substellar. The properties of this sytem - close projected separation (1.8+/-0.3 AU) and near unity mass ratio - are consistent with previous results for very low-mass field binaries. The relatively short estimated orbital period of this system (~7-12 yr) makes it a good target for dynamical mass measurements. Interestingly, the system's angular separation is the tightest yet for any very low-mass binary published from a ground-based telescope and is the tightest binary discovered with laser guide star adaptive optics to date.Comment: 10 pages, 3 figures; accepted for publication to A

Further evidence for increased macrophage migration inhibitory factor expression in prostate cancer

BACKGROUND: Macrophage migration inhibitory factor (MIF) is a cytokine associated with prostate cancer, based on histologic evidence and circulating (serum) levels. Recent studies from another laboratory failed to document these results. This study's aims were to extend and confirm our previous data, as well as to define possible mechanisms for the discrepant results. Additional aims were to examine MIF expression, as well as the location of MIF's receptor, CD74, in human prostatic adenocarcinoma compared to matched benign prostate. METHODS: MIF amounts were determined in random serum samples remaining following routine PSA screening by ELISA. Native, denaturing and reducing polyacrylamide gels and Western blot analyses determined the MIF form in serum. Prostate tissue arrays were processed for MIF in situ hybridization and immunohistochemistry for MIF and CD74. MIF released into culture medium from normal epithelial, LNCaP and PC-3 cells was detected by Western blot analysis. RESULTS: Median serum MIF amounts were significantly elevated in prostate cancer patients (5.87 ± 3.91 ng/ml; ± interquartile range; n = 115) compared with patients with no documented diagnosis of prostate cancer (2.19 ± 2.65 ng/ml; n = 158). ELISA diluent reagents that included bovine serum albumin (BSA) significantly reduced MIF serum detection (p < 0.01). MIF mRNA was localized to prostatic epithelium in all samples, but cancer showed statistically greater MIF expression. MIF and its receptor (CD74) were localized to prostatic epithelium. Increased secreted MIF was detected in culture medium from prostate cancer cell lines (LNCaP and PC-3). CONCLUSION: Increased serum MIF was associated with prostate cancer. Diluent reagents that included BSA resulted in MIF serum immunoassay interference. In addition, significant amounts of complexed MIF (180 kDa under denaturing conditions by Western blot) found in the serum do not bind to the MIF capture antibody. Increased MIF mRNA expression was observed in prostatic adenocarcinoma compared to benign tissue from matched samples, supporting our earlier finding of increased MIF gene expression in prostate cancer

Protoplanetary and Transitional Disks in the Open Stellar Cluster IC 2395

We present new deep UBVRI images and high-resolution multi-object optical spectroscopy of the young (~ 6 - 10 Myr old), relatively nearby (800 pc) open cluster IC 2395. We identify nearly 300 cluster members and use the photometry to estimate their spectral types, which extend from early B to middle M. We also present an infrared imaging survey of the central region using the IRAC and MIPS instruments on board the Spitzer Space Telescope, covering the wavelength range from 3.6 to 24 microns. Our infrared observations allow us to detect dust in circumstellar disks originating over a typical range of radii ~ 0.1 to ~ 10AU from the central star. We identify 18 Class II, 8 transitional disk, and 23 debris disk candidates, respectively 6.5%, 2.9%, and 8.3% of the cluster members with appropriate data. We apply the same criteria for transitional disk identification to 19 other stellar clusters and associations spanning ages from ~ 1 to ~ 18 Myr. We find that the number of disks in the transitional phase as a fraction of the total with strong 24 micron excesses ([8] - [24] > 1.5) increases from 8.4 +\- 1.3% at ~ 3 Myr to 46 +\- 5% at ~ 10 Myr. Alternative definitions of transitional disks will yield different percentages but should show the same trend.Comment: accepted by the Astrophysical Journa

The physiological stress response to anaerobic exercise is altered following sodium bicarbonate supplementation

Sodium bicarbonate (NaHCO3) is a nutritional aid that is proposed to enhance performance by reducing the state of exercise induced acidosis, however research is currently equivocal. Despite this, most research still focuses on its effects upon performance, and not whether the reduced acidosis impacts upon any other factors related to exercise. There is some research to suggest that such a reduction in [H+] can attenuate a number of physiological stress pathways such as stress hormones (1, 4), heat shock protein 72 (HSP72) and oxidative stress (3), suggesting a potential role in exercise recovery. However there are some limitations with this previous research as work intensities were not controlled for, hence making comparisons between treatments difficult. Also limited markers of stress were measured despite the physiological stress response being multi-faceted. The aim of this study was to examine whether the ingestion of NaHCO3 would influence the expression of several markers of stress measured simultaneously, following a work controlled anaerobic exercise

Identifying Primordial Substructure in NGC 2264

We present new Spitzer Space Telescope observations of the young cluster NGC2264. Observations at 24 micron with the Multiband Imaging Photometer has enabled us to identify the most highly embedded and youngest objects in NGC2264. This letter reports on one particular region of NGC2264 where bright 24 micron sources are spatially configured in curious linear structures with quasi-uniform separations. The majority of these sources (~60% are found to be protostellar in nature with Class I spectral energy distributions. Comparison of their spatial distribution with sub-millimeter data from Wolf-Chase (2003) and millimeter data from Peretto et al. (2005) shows a close correlation between the dust filaments and the linear spatial configurations of the protostars, indicating that star formation is occurring primarily within dense dusty filaments. Finally, the quasi-uniform separations of the protostars are found to be comparable in magnitude to the expected Jeans length suggesting thermal fragmentation of the dense filamentary material.Comment: Accepted for publication in ApJL, 5 pages, 4 figures. Color version available from the following webpages: http://cfa-www.harvard.edu/~pteixeir/ and http://cfa-www.harvard.edu/~clada