Plasticization and Morphology Development in Dynamically Vulcanized Thermoplastic Elastomers

Dynamically vulcanized thermoplastic elastomers constitute one of the main categories among various types of thermoplastic elastomers (TPEs). Due to the commercial importance of this particular group of TPEs, tremendous efforts have been dedicated to improve the understanding and control the phase morphology development. The ultimate goal is to obtain materials with improved physical and mechanical properties. As in other polymeric compounds, the parameters during the mixing stage have a significant influence on the final morphology of dynamically vulcanized blends. Furthermore, the phase morphology and, therefore, the distribution of elastomeric domains in the thermoplastic phase are also strongly dependent on the formulation. This chapter discusses the main important processing factors and, more specifically, highlights the effects of plasticization and curing on the morphology development of dynamically vulcanized thermoplastic elastomer blends. The following text provides fundamental information on how one should take into consideration each parameter affecting the morphology of nonreactive and reactive elastomer/thermoplastic blends

A Partial Taxonomy of Substitutability and Interchangeability

Substitutability, interchangeability and related concepts in Constraint Programming were introduced approximately twenty years ago and have given rise to considerable subsequent research. We survey this work, classify, and relate the different concepts, and indicate directions for future work, in particular with respect to making connections with research into symmetry breaking. This paper is a condensed version of a larger work in progress.Comment: 18 pages, The 10th International Workshop on Symmetry in Constraint Satisfaction Problems (SymCon'10

Cultural Preservation of Ethnomedicine in Peru

In conjunction with the Minority Health & Health Disparities International Research Training program at San Diego State University, three Linfield students contributed to the ongoing Peru Ethnomedical Project in Trujillo, Peru by: Conducting surveys in two neighborhoods on the edge of the city; Creating a medicinal plant garden in the Chan Chan archaeological site museum. Surveys conducted in Moche, Trujillo were part of a larger study supervised by anthropologists Douglas Sharon and Thomas Love. The research aims to evaluate the usage of medicinal plants in rural and urban Peruvian communities. Linfield’s contribution focused on the creation of the medicinal garden to serve as a community model and educational program. The overall purpose of the 2015 summer faculty collaborative project was to: Preserve the knowledge of these practices; Analyze the plant properties; Publish the information; Provide the community with a garden that reflects the commonly used plants; Educate new generations; Bring back and apply this knowledge in the Linfield community

Consistency of f(R)=R2−R02f(R)=\sqrt{R^{2}-R_{0}^2} Gravity with the Cosmological Observations in Palatini Formalism

In this work we study the dynamics of universe in $f(R)=\sqrt{R^2-R_{0}^2}$ modified gravity with Palatini formalism. We use data from recent observations as Supernova Type Ia (SNIa) Gold sample and Supernova Legacy Survey (SNLS) data, size of baryonic acoustic peak from Sloan Digital Sky Survey (SDSS), the position of the acoustic peak from the CMB observations and large scale structure formation (LSS) from the 2dFGRS survey to put constraint on the parameters of the model. To check the consistency of this action, we compare the age of old cosmological objects with the age of universe. In the combined analysis with the all the observations, we find the parameters of model as $R_0=6.192_{-0.177}^{+0.167}\times H_0^2$ and $\Omega_m=0.278_{-0.278}^{+0.273}$.Comment: 12 pages, 7 figure

Platelet release of Vascular Endothelial Growth Factor (VEGF) in patients undergoing chemotherapy for breast cancer

<p>Abstract</p> <p>Background</p> <p>Venous thromboembolism (VTE) following breast cancer chemotherapy is common. Chemotherapy-induced alterations in markers of haemostasis occur during chemotherapy. In this study we investigated the changes in serum and plasma VEGF, together with platelet release of VEGF and related these to the development of VTE at 3 months.</p> <p>Methods</p> <p>Serum and plasma VEGF, together with platelet release of VEGF were measured prior to chemotherapy and at 24 hours; four-, eight days and three months following commencement of chemotherapy in early and advanced breast cancer patients and in age and sex matched controls. Duplex ultrasound imaging was performed after one month or if symptomatic.</p> <p>Results</p> <p>Of 123 patients 9.8% developed VTE within three months. Serum and plasma VEGF were increased in advanced breast cancer as was platelet release of VEGF. Prior to chemotherapy a 100 μg/ml increase in serum VEGF was associated with a 40% increased risk of VTE, while a 10 μg/ml increase in plasma VEGF was associated with a 20% increased risk of VTE. Serum VEGF showed a different response to chemotherapy in those who developed VTE.</p> <p>Conclusion</p> <p>A group of patients at risk of VTE could be identified, allowing targeted thrombopropylaxis. Whether or not the response in VEGF during chemotherapy has any angiogenic significance remains to be elucidated.</p

Antegrade common femoral artery closure device use is associated with decreased complications.

ObjectiveAntegrade femoral artery access is often used for ipsilateral infrainguinal peripheral vascular intervention. However, the use of closure devices (CD) for antegrade access (AA) is still considered outside the instructions for use for most devices. We hypothesized that CD use for antegrade femoral access would not be associated with an increased odds of access site complications.MethodsThe Vascular Quality Initiative was queried from 2010 to 2019 for infrainguinal peripheral vascular interventions performed via femoral AA. Patients who had a cutdown or multiple access sites were excluded. Cases were then stratified into whether a CD was used or not. Hierarchical multivariable logistic regressions controlling for hospital-level variation were used to examine the independent association between CD use and access site complications. A sensitivity analysis using coarsened exact matching was performed using factors different between treatment groups to reduce imbalance between the groups.ResultsOverall, 11,562 cases were identified and 5693 (49.2%) used a CD. Patients treated with a CD were less likely to be white (74.1% vs 75.2%), have coronary artery disease (29.7% vs 33.4%), use aspirin (68.7% vs 72.4%), and have heparin reversal with protamine (15.5% vs 25.6%; all P&nbsp;&lt; .05). CD patients were more likely to be obese (31.6% vs 27.0%), have an elective operation (82.6% vs 80.1%), ultrasound-guided access (75.5% vs 60.6%), and a larger access sheath (6.0&nbsp;± 1.0&nbsp;F vs 5.5&nbsp;± 1.0&nbsp;F; P&nbsp;&lt; .05 for all). CD cases were less likely to develop any access site hematoma (2.55% vs 3.53%; P&nbsp;&lt; .01) or a hematoma requiring reintervention (0.63% vs 1.26%; P&nbsp;&lt; .01) and had no difference in access site stenosis or occlusion (0.30% vs 0.22%; P&nbsp;= .47) compared with no CD. On multivariable analysis, CD cases had significantly decreased odds of developing any access site hematoma (odds ratio, 0.75; 95% confidence interval, 0.59-0.95) and a hematoma requiring intervention (odds ratio, 0.56; 95% confidence interval, 0.38-0.81). A sensitivity analysis after coarsened exact matching confirmed these findings.ConclusionsIn this nationally representative sample, CD use for AA was associated with a lower odds of hematoma in selected patients. Extending the instructions for use indications for CDs to include femoral AA may decrease the incidence of access site complications, patient exposure to reintervention, and costs to the health care system

Prospects for Detecting Dark Matter Halo Substructure with Pulsar Timing

One of the open questions of modern cosmology is the nature and properties of the Dark Matter halo and its substructures. In this work we study the gravitational effect of dark matter substructures on pulsar timing observations. Since millisecond pulsars are stable and accurate emitters, they have been proposed as plausible astrophysical tools to probe the gravitational effects of dark matter structures. We study this effect on pulsar timing through Shapiro time delay (or Integrated Sachs-Wolfe (ISW) effect) and Doppler effects statistically, showing that the latter dominates the signal. For this task, we relate the power spectrum of pulsar frequency change to the matter power spectrum on small scales, which we compute using the stable clustering hypothesis. We compare this power spectrum with the reach of current and future observations of pulsar timing designed for gravitational wave (GW) detection. Our results show that while current observations are unable to detect these signals, the sensitivity of the upcoming Square Kilometer Array (SKA) is only a factor of few weaker than our optimistic predictions.Comment: 12 pages, 10 figures. Final Versio

Impact of diastolic dysfunction severity on global left ventricular volumetric filling - assessment by automated segmentation of routine cine cardiovascular magnetic resonance

<p>Abstract</p> <p>Objectives</p> <p>To examine relationships between severity of echocardiography (echo) -evidenced diastolic dysfunction (DD) and volumetric filling by automated processing of routine cine cardiovascular magnetic resonance (CMR).</p> <p>Background</p> <p>Cine-CMR provides high-resolution assessment of left ventricular (LV) chamber volumes. Automated segmentation (LV-METRIC) yields LV filling curves by segmenting all short-axis images across all temporal phases. This study used cine-CMR to assess filling changes that occur with progressive DD.</p> <p>Methods</p> <p>115 post-MI patients underwent CMR and echo within 1 day. LV-METRIC yielded multiple diastolic indices - E:A ratio, peak filling rate (PFR), time to peak filling rate (TPFR), and diastolic volume recovery (DVR₈₀- proportion of diastole required to recover 80% stroke volume). Echo was the reference for DD.</p> <p>Results</p> <p>LV-METRIC successfully generated LV filling curves in all patients. CMR indices were reproducible (≤ 1% inter-reader differences) and required minimal processing time (175 ± 34 images/exam, 2:09 ± 0:51 minutes). CMR E:A ratio decreased with grade 1 and increased with grades 2-3 DD. Diastolic filling intervals, measured by DVR₈₀or TPFR, prolonged with grade 1 and shortened with grade 3 DD, paralleling echo deceleration time (p < 0.001). PFR by CMR increased with DD grade, similar to E/e' (p < 0.001). Prolonged DVR₈₀identified 71% of patients with echo-evidenced grade 1 but no patients with grade 3 DD, and stroke-volume adjusted PFR identified 67% with grade 3 but none with grade 1 DD (matched specificity = 83%). The combination of DVR₈₀and PFR identified 53% of patients with grade 2 DD. Prolonged DVR₈₀was associated with grade 1 (OR 2.79, CI 1.65-4.05, p = 0.001) with a similar trend for grade 2 (OR 1.35, CI 0.98-1.74, p = 0.06), whereas high PFR was associated with grade 3 (OR 1.14, CI 1.02-1.25, p = 0.02) DD.</p> <p>Conclusions</p> <p>Automated cine-CMR segmentation can discern LV filling changes that occur with increasing severity of echo-evidenced DD. Impaired relaxation is associated with prolonged filling intervals whereas restrictive filling is characterized by increased filling rates.</p