Human Processing of Behaviorally Relevant and Irrelevant Absence of Expected Rewards: A High-Resolution ERP Study

Acute lesions of the posterior medial orbitofrontal cortex (OFC) in humans may induce a state of reality confusion marked by confabulation, disorientation, and currently inappropriate actions. This clinical state is strongly associated with an inability to abandon previously valid anticipations, that is, extinction capacity. In healthy subjects, the filtering of memories according to their relation with ongoing reality is associated with activity in posterior medial OFC (area 13) and electrophysiologically expressed at 220–300 ms. These observations indicate that the human OFC also functions as a generic reality monitoring system. For this function, it is presumably more important for the OFC to evaluate the current behavioral appropriateness of anticipations rather than their hedonic value. In the present study, we put this hypothesis to the test. Participants performed a reversal learning task with intermittent absence of reward delivery. High-density evoked potential analysis showed that the omission of expected reward induced a specific electrocortical response in trials signaling the necessity to abandon the hitherto reward predicting choice, but not when omission of reward had no such connotation. This processing difference occurred at 200–300 ms. Source estimation using inverse solution analysis indicated that it emanated from the posterior medial OFC. We suggest that the human brain uses this signal from the OFC to keep thought and behavior in phase with reality

Spatio-Temporal Pattern of Saturn's Equatorial Oscillation

Recent ground-based and Cassini CIRS thermal-infrared data have characterized the spatial and temporal characteristics of an equatorial oscillation in the middle atmosphere of Saturn above the 100-mbar level. The CIRS data [I] indicated a pattern of warm and cold anomalies near the equator, stacked vertically in alternating fashion. The ground-based observations s2, although not having the altitude range or vertical resolution of the CIRS observations, covered several years and indicated an oscillation cycle of approx.15 years, roughly half of Saturn's year. In Earth's middle atmosphere, both the quasi-biennial (approx.26 months) and semi-annual equatorial oscillations have been extensively observed and studied (see e.g., [3]), These exhibit a pattern of alternating warmer and cooler zonal-mean temperatures with altitude, relative to those at subtropical latitudes. Consistent with the thermal wind equation, this is also associated with an alternating pattern of westerly and easterly zonal winds. Moreover, the pattern of winds and temperatures descends with time. Momentum deposition by damped vertically propagating waves is thought to play a key role m forcing both types of oscillation, and it can plausibly account for the descent. Here we report the direct observation of this descent in Saturn's equatorial atmosphere from Cassini radio occultation soundings in 2005 and 2009. The retrieved temperatures are consistent with a descent of 0.7 x the pressure scale height. The descent rate is related to the magnitude of the wave forcing, radiative damping, and induced meridional circulations. We discuss possible implications

Time of exposure to social defeat stress during childhood and adolescence and redox dysregulation on long-lasting behavioral changes, a translational study.

Traumatic events during childhood/early adolescence can cause long-lasting physiological and behavioral changes with increasing risk for psychiatric conditions including psychosis. Genetic factors and trauma (and their type, degree of repetition, time of occurrence) are believed to influence how traumatic experiences affect an individual. Here, we compared long-lasting behavioral effects of repeated social defeat stress (SD) applied during either peripuberty or late adolescence in adult male WT and Gclm-KO mice, a model of redox dysregulation relevant to schizophrenia. As SD disrupts redox homeostasis and causes oxidative stress, we hypothesized that KO mice would be particularly vulnerable to such stress. We first found that peripubertal and late adolescent SD led to different behavioral outcomes. Peripubertal SD induced anxiety-like behavior in anxiogenic environments, potentiated startle reflex, and increased sensitivity to the NMDA-receptor antagonist, MK-801. In contrast, late adolescent SD led to increased exploration in novel environments. Second, the long-lasting impact of peripubertal but not late adolescent SD differed in KO and WT mice. Peripubertal SD increased anxiety-like behavior in anxiogenic environments and MK-801-sensitivity mostly in KO mice, while it increased startle reflex in WT mice. These suggest that a redox dysregulation during peripuberty interacts with SD to remodel the trajectory of brain maturation, but does not play a significant role during later SD. As peripubertal SD induced persisting anxiety- and fear-related behaviors in male mice, we then investigated anxiety in a cohort of 89 early psychosis male patients for whom we had information about past abuse and clinical assessment during the first year of psychosis. We found that a first exposure to physical/sexual abuse (analogous to SD) before age 12, but not after, was associated with higher anxiety at 6-12 months after psychosis onset. This supports that childhood/peripuberty is a vulnerable period during which physical/sexual abuse in males has wide and long-lasting consequences

Saturn's Equatorial Oscillation: Evidence of Descending Thermal Structure from Cassini Radio Occultations

Ground-based and Cassini CIRS thermal-infrared data have characterized the spatial and temporal characteristics of an equatorial oscillation in Saturn's middle atmosphere above the 100-mbar level. The CIRS data indicate a vertical pattern of alternating warm and cold anomalies at the equator. From the thermal wind equation this implies a concomitant reversal of zonal winds with attitude, relative to the cloud-top winds, with peak-to-peak amplitude approximately 200 meters per second. The ground-based observations do not having the altitude range or vertical resolution of the CIRS observations, but they cover several years and indicate an oscillation cycle of 1 years, roughly half of Saturn's year. Equatorial oscillations in Earth's middle atmosphere have primarily exhibited either quasi-biennial or semi-annual "periodicities," and both types have been extensively observed and modeled. They exhibit a vertical pattern of alternating warmer and cooler zonal-mean temperatures and zonal winds analogous to that described above for Saturn. Moreover, the pattern of winds and temperatures descends with time. Momentum deposition by damped vertically propagating easterly and westerly waves is thought to play a key role in forcing both types of oscillation, and it can plausibly account for the descent. Here we report the direct observation of this descent in Saturn's equatorial atmosphere from Cassini radio occultation soundings in 2005 and 2009. The retrieved temperatures are consistent with a descent of 0.6 x the pressure scale height over this time period. The descent rate is related to the magnitude of the wave forcing, radiative damping, and induced meridional circulations. A simple calculation implies that vertical wave fluxes of zonal momentum approximately 0.05 square meters per square second could account for the observed vertical descent on Saturn, which is comparable to the magnitude of the wave fluxes associated with the terrestrial quasi-biennial oscillation

From Quantum Universal Enveloping Algebras to Quantum Algebras

The ``local'' structure of a quantum group G_q is currently considered to be an infinite-dimensional object: the corresponding quantum universal enveloping algebra U_q(g), which is a Hopf algebra deformation of the universal enveloping algebra of a n-dimensional Lie algebra g=Lie(G). However, we show how, by starting from the generators of the underlying Lie bialgebra (g,\delta), the analyticity in the deformation parameter(s) allows us to determine in a unique way a set of n ``almost primitive'' basic objects in U_q(g), that could be properly called the ``quantum algebra generators''. So, the analytical prolongation (g_q,\Delta) of the Lie bialgebra (g,\delta) is proposed as the appropriate local structure of G_q. Besides, as in this way (g,\delta) and U_q(g) are shown to be in one-to-one correspondence, the classification of quantum groups is reduced to the classification of Lie bialgebras. The su_q(2) and su_q(3) cases are explicitly elaborated.Comment: 16 pages, 0 figures, LaTeX fil

Three dimensional quantum algebras: a Cartan-like point of view

A perturbative quantization procedure for Lie bialgebras is introduced and used to classify all three dimensional complex quantum algebras compatible with a given coproduct. The role of elements of the quantum universal enveloping algebra that, analogously to generators in Lie algebras, have a distinguished type of coproduct is discussed, and the relevance of a symmetrical basis in the universal enveloping algebra stressed. New quantizations of three dimensional solvable algebras, relevant for possible physical applications for their simplicity, are obtained and all already known related results recovered. Our results give a quantization of all existing three dimensional Lie algebras and reproduce, in the classical limit, the most relevant sector of the complete classification for real three dimensional Lie bialgebra structures given by X. Gomez in J. Math. Phys. Vol. 41. (2000) 4939.Comment: LaTeX, 15 page

Multicenter phase II trial of preoperative induction chemotherapy followed by chemoradiation with docetaxel and cisplatin for locally advanced esophageal carcinoma (SAKK 75/02)

Background: This multicenter phase II study investigated the efficacy and feasibility of preoperative induction chemotherapy followed by chemoradiation and surgery in patients with esophageal carcinoma. Patients and methods: Patients with locally advanced resectable squamous cell carcinoma or adenocarcinoma of the esophagus received induction chemotherapy with cisplatin 75 mg/m2 and docetaxel (Taxotere) 75 mg/m2 on days 1 and 22, followed by radiotherapy of 45 Gy (25 × 1.8 Gy) and concurrent chemotherapy comprising cisplatin 25 mg/m2 and docetaxel 20 mg/m2 weekly for 5 weeks, followed by surgery. Results: Sixty-six patients were enrolled at eleven centers and 57 underwent surgery. R0 resection was achieved in 52 patients. Fifteen patients showed complete, 16 patients nearly complete and 26 patients poor pathological remission. Median overall survival was 36.5 months and median event-free survival was 22.8 months. Squamous cell carcinoma and good pathologically documented response were associated with longer survival. Eighty-two percent of all included patients completed neoadjuvant therapy and survived for 30 days after surgery. Dysphagia and mucositis grade 3/4 were infrequent (<9%) during chemoradiation. Five patients (9%) died due to surgical complications. Conclusions: This neoadjuvant, taxane-containing regimen was efficacious and feasible in patients with locally advanced esophageal cancer in a multicenter, community-based setting and represents a suitable backbone for further investigatio

Transcriptional Activation of Pyoluteorin Operon Mediated by the LysR-Type Regulator PltR Bound at a 22 bp lys Box in Pseudomonas aeruginosa M18

Pseudomonas aeruginosa M18, a rhizosphere-isolated bacterial strain showing strong antifungal activity, can produce secondary metabolites such as phenazine-1-carboxylic acid and pyoluteorin (Plt). The LysR-type transcriptional regulator PltR activates the Plt biosynthesis operon pltLABCDEFG, the expression of which is induced by Plt. Here, we identified and characterized the non-conserved pltL promoter (pltLp) specifically activated by PltR and its upstream neighboring lys box from the complicated pltR–pltL intergenic sequence. The 22 bp palindromic lys box, which consists of two 9 bp complementary inverted repeats interrupted by 4 bp, was found to contain the conserved, GC-rich LysR-binding motif (T-N11-A). Evidence obtained in vivo from mutational and lacZ report analyses and in vitro from electrophoretic mobility shift assays reveals that the PltR protein directly bound to the pltLp region as the indispensable binding motif “lys box”, thereby transcriptionally activating the pltLp-driven plt operon expression. Plt, as a potential non-essential coinducer of PltR, specifically induced the pltLp expression and thus strengthened its biosynthetic plt operon expression