Triumphal Transposals

Recent developments in logology compel me to come out of retirement, setting the record straight. Articles and/or Colloquy items in the February 1976, May 1976, and February 1981 issues of Word Ways have presented numerous transposals of 15 or more letters. Most of these transposals have been of the trivial variety, involving interchanges of individual letters or of blocks of letters. Such transposals have the same standing in the realm of transposals that tautonymic 10x10 word squares have in the domain of geometric forms

Puddle Jumping: How do young children manage their grief following the death of their sibling and how do mothers use continuing bonds to maintain their children's relationship in the living world?

This thesis examines the narratives of four mothers who are bereaved of one of their children and are parenting living children. The study used an Interpretative Phenomenological Analysis to explore the lived experiences of bereaved siblings through the stories told by their mothers. Previous research exploring the impact on children following the death of a sibling, indicates the potential long-lasting impact on their emotional wellbeing, but there is a scarcity of research which focuses on the younger child and the practice of continuing bonds by their mother. A review of the literature focuses on the traditions, rituals and practices enacted by mothers as they endeavour to create or to maintain relationships between all their children; those who have died and those in the living world. A case study approach has been adopted across four case studies and includes semistructured interviews with each child’s mother using Interpretative Phenomenological Analysis (IPA) to demonstrate their lived experiences. Rich narratives allow an insight into how young siblings can manage their grief and maintain a relationship with their sibling. Analysis of the data revealed the importance of this sibling relationship and the ways in which the children’s mothers incorporated the memories of their dead children into their lives of their living children. The data revealed that grief is felt even when a sibling was not known in the living world and that living siblings share stories and memories and are an important part of continuing bonds. Mothers spoke with love, hope, and confidence about all their children and of their determination to ensure their siblings remained in each other's lives. The thesis also demonstrates the tensions felt amongst educational professionals and western society in talking to young children about death and how their voice can become silenced, contributing to their grief. Mothers play a key role in forging and maintaining the bond between their living and dead children, but further research in this area is needed

Forest Restoration in a Mixed-Ownership Landscape under Climate Change

The article presents a study regarding forest management associated with climate change. It mentions that preservation endeavors and restoration schemes should diminish current threats like unsuited forest management and development while integrating possible effects of climate change. It also stresses that an adaptive approach to management can be the most efficient strategy of forest restoration given the doubts of climate change impacts

Deep Learning Design for Social Innovation: Participatory Radio for Developing 21C Skills with Disenfranchised Learners

Deep Learning Design has been proposed as an approach to Technology Enhanced Learning (TEL) that foregrounds principles of learning and con-text over simply extrapolating the affordances of new technologies. An original application of this approach has been within contexts necessitating social innovation to promote the inclusion, non-formal learning and employability of disenfranchised learners across Europe – RadioActive101. This approach has actively developed, implemented and evaluated five radio hubs with at-risk young people and other disenfranchised groups to develop digital competencies and employability skills for the 21st Century. This Learning Design and associated competencies are mapped to a progression and accreditation model linking EU key competencies to RadioActive101 activities and performances that are recognised through open electronic 'badges'. Evaluation findings showed particularly positive results, and impact and value beyond the non-formal learning of technical and employability skills, such as improvements in confidence, self-esteem and general self-efficacy of individuals and organisational learning and development. We conclude this article by asking how and whether current approaches to learning design can accommodate such essential psychosocial dimensions of learning

RadioActive101-Learning through radio, learning for life: an international approach to the inclusion and non-formal learning of socially excluded young people

This article describes an original international approach to inclusion and non-formal learning of socially excluded young people, through participatory internet radio - RadioActive101. First, we critically discuss the social and digital exclusion of young people. We then describe our approach - that includes participatory action research methods that are influenced by the work of Dewey and Freire, and operate as a process of complex intervention. This supports the inclusive co-production of radio content in ways that support non-formal learning in two EU contexts–the UK and Portugal. We then summarise and compare a qualitative investigation of RadioActive101. This showed positive results, with important similarities and differences between the two contexts. Participants reported that RadioActive101 was motivating and contributed to the development of contemporary skills, and also stimulated improvements in psychosocial dimensions such as confidence (self-efficacy) and self-esteem. This investigation informed the development of an original recognition system for non-formal learning that maps EU Key Competences for Lifelong Learning to radio practices and activities that are recognised through electronic badges. Our reflections emphasise that in order to support the non-formal learning of socially excluded young people we must foreground our attention to fostering psychosocial dimensions alongside developing contemporary competences.info:eu-repo/semantics/acceptedVersio

Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues

The immature phenotype of stem cell derived cardiomyocytes is a significant barrier to their use in translational medicine and pre-clinical in vitro drug toxicity and pharmacological analysis. Here we have assessed the contribution of non-myocyte cells on the contractile function of co-cultured human embryonic stem cell derived cardiomyocytes (hESC-CMs) in spheroid microtissue format. Microtissues were formed using a scaffold free 96-well cell suspension method from hESC-CM cultured alone (CM microtissues) or in combination with human primary cardiac microvascular endothelial cells and cardiac fibroblasts (CMEF microtissues). Contractility was characterized with fluorescence and video-based edge detection. CMEF microtissues displayed greater Ca(2+ )transient amplitudes, enhanced spontaneous contraction rate and remarkably enhanced contractile function in response to both positive and negative inotropic drugs, suggesting a more mature contractile phenotype than CM microtissues. In addition, for several drugs the enhanced contractile response was not apparent when endothelial cell or fibroblasts from a non-cardiac tissue were used as the ancillary cells. Further evidence of maturity for CMEF microtissues was shown with increased expression of genes that encode proteins critical in cardiac Ca(2+ )handling (S100A1), sarcomere assembly (telethonin/TCAP) and β-adrenergic receptor signalling. Our data shows that compared with single cell-type cardiomyocyte in vitro models, CMEF microtissues are superior at predicting the inotropic effects of drugs, demonstrating the critical contribution of cardiac non-myocyte cells in mediating functional cardiotoxicity

Clinical assessment, investigation, diagnosis and initial management of cerebral visual impairment: a consensus practice guide

Cerebral Visual Impairment (CVI) is a common condition in the UK. Patients with conditions associated with CVI are frequently seen in paediatric ophthalmology clinics offering eye care professionals an opportunity to identify children proactively. In most cases CVI occurs as part of a neurodevelopmental condition or as a feature of multiple and complex disabilities. However, CVI can also be seen in children with apparently typical development. In some cases, high contrast visual acuity is normal and in other cases severely impaired. As such, identification of CVI requires evaluation of aspects of visual performance beyond high contrast acuity and consideration that visual function of those with CVI may fluctuate. Few paediatric ophthalmologists have received formal training in CVI. The detection and diagnosis of CVI varies across the UK and patients report hugely different experiences. A diagnosis of CVI is made based on professional clinical judgement and it is recognised that individual perspectives and local practice in the specific methodologies of assessment will vary. A systematic review and survey of professionals is underway to attempt to reach agreement on diagnostic criteria. Nonetheless, established pathways and published protocols can offer guidance on how a paediatric ophthalmology service can approach assessment of the child with suspected CVI. The purpose of this paper is to present a summary of research and clinical practice methods for detecting and diagnosing CVI in a paediatric ophthalmology outpatient setting. It represents current understanding of the topic and acknowledges the evolving nature of both practice and the evidence-base. A rapid literature review was undertaken to identify articles relating to clinical investigation of children with CVI. A focus group of QTVI and subject matter experts from sight loss charities was undertaken to address areas which were not covered by the literature review