Synchronization of interconnected networks: the role of connector nodes

In this Letter we identify the general rules that determine the synchronization properties of interconnected networks. We study analytically, numerically and experimentally how the degree of the nodes through which two networks are connected influences the ability of the whole system to synchronize. We show that connecting the high-degree (low-degree) nodes of each network turns out to be the most (least) effective strategy to achieve synchronization. We find the functional relation between synchronizability and size for a given network-of-networks, and report the existence of the optimal connector link weights for the different interconnection strategies. Finally, we perform an electronic experiment with two coupled star networks and conclude that the analytical results are indeed valid in the presence of noise and parameter mismatches.Comment: Accepted for publication in Physical Review Letters. Main text: 5 pages, 4 figures. Supplemental material: 8 pages, 3 figure

Valuing condition specific health states using simulation contact lenses

OBJECTIVE: This paper reports on a study that used contact lenses to simulate the effects of a visual impairment caused by Age Related Macular Degeneration (ARMD). The aim was to examine the feasibility of using this method of simulation and to compare the results from this experiment with those obtained from ARMD patients (n=209) using generic preference-based measures (HUI3 and EQ-5D) and patient time trade-off TTO. METHODS: Utility values were elicited from healthy participants (n=108) by TTO for three ARMD states simulated using contact lenses. RESULTS: A significant relationship was found between visual acuity and TTO values elicited from members of the general population (n=108). It was stronger than that found for HUI3, EQ-5D and own TTO values from patients (n=209). General population values informed by the experience of simulation were found to be significantly different to values from patient TTO and generic preference-based measures for the same level of visual impairment. Socio-demographic characteristics did not significantly affect results, although baseline TTO utility values were positively associated with TTO values for simulated states. CONCLUSIONS: ARMD has a major impact on general population TTO health state values. Differences across four visual health states appear larger than those found for a generic preference-based measures and patient TTO values. For conditions that are difficult to describe and imagine, simulation methods may offer an important method for obtaining better informed general population preferences

Topological Measure Locating the Effective Crossover between Segregation and Integration in a Modular Network

We introduce an easily computable topological measure which locates the effective crossover between segregation and integration in a modular network. Segregation corresponds to the degree of network modularity, while integration is expressed in terms of the algebraic connectivity of an associated hyper-graph. The rigorous treatment of the simplified case of cliques of equal size that are gradually rewired until they become completely merged, allows us to show that this topological crossover can be made to coincide with a dynamical crossover from cluster to global synchronization of a system of coupled phase oscillators. The dynamical crossover is signaled by a peak in the product of the measures of intra-cluster and global synchronization, which we propose as a dynamical measure of complexity. This quantity is much easier to compute than the entropy (of the average frequencies of the oscillators), and displays a behavior which closely mimics that of the dynamical complexity index based on the latter. The proposed toplogical measure simultaneously provides information on the dynamical behavior, sheds light on the interplay between modularity vs total integration and shows how this affects the capability of the network to perform both local and distributed dynamical tasks

Experimental implementation of maximally synchronizable networks

Maximally synchronizable networks (MSNs) are acyclic directed networks that maximize synchronizability. In this paper, we investigate the feasibility of transforming networks of coupled oscillators into their corresponding MSNs. By tuning the weights of any given network so as to reach the lowest possible eigenratio lambdaN/lambda2, the synchronized state is guaranteed to be maintained across the longest possible range of coupling strengths. We check the robustness of the resulting MSNs with an experimental implementation of a network of nonlinear electronic oscillators and study the propagation of the synchronization errors through the network. Importantly, a method to study the effects of topological uncertainties on the synchronizability is proposed and explored both theoretically and experimentally.The authors acknowledge J.L. Echenausía-Monroy, V.P. Vera-Ávila, J. Moreno de León, C. Hapo and P.L. del Barrio for assistance in the laboratory, and the support of MINECO (FIS2012-38949-C03-01 and FIS2013-41057-P). One anonymous referee is acknowledged for having provided valuable advice that has influenced our understanding of the origin of the propagation of the synchronization error, and helped us improve the manuscript in several ways. The authors also acknowledge the computational resources, facilities and assistance provided by the Centro computazionale di RicErca sui Sistemi COmplessi (CRESCO) of the Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA). R.S.E. acknowledges Universidad de Guadalajara, CULagos (Mexico) for financial support (PRO-SNI-2015/228069, PROINPEP/005/2014, UDG-CONACyT/I010/163/2014) and CONACyT (Becas Mixtas MZO2015/290842). D.-U. Hwang acknowledges National Institute for Mathematical Sciences (NIMS) funded by the Ministry of Science, ICT & Future Planning (A21501-3)

A general review and discussion on geodetic control of the moon

Prepared for National Aeronautics and Space Administration, Manned Spacecraft Center, Houston, Texas: Contract No. NAS 9-9695, OSURF Project No. 284

Diverse strategic identities induce dynamical states in evolutionary games

Evolutionary games provide the theoretical backbone for many aspects of our social life: from cooperation to crime, from climate inaction to imperfect vaccination and epidemic spreading, from antibiotics overuse to biodiversity preservation. An important, and so far overlooked, aspect of reality is the diverse strategic identities of individuals. While applying the same strategy to all interaction partners may be an acceptable assumption for simpler forms of life, this fails to account} for the behavior of more complex living beings. For instance, we humans act differently around different people. Here we show that allowing individuals to adopt different strategies with different partners yields a very rich evolutionary dynamics, including time-dependent coexistence of cooperation and defection, system-wide shifts in the dominant strategy, and maturation in individual choices. Our results are robust to variations in network type and size, and strategy updating rules. Accounting for diverse strategic identities thus has far-reaching implications in the mathematical modeling of social games.Comment: 9 pages, 4 figure

Antimicrobial peptides of the Cecropin-family show potent antitumor activity against bladder cancer cells

<p>Abstract</p> <p>Background</p> <p>This study evaluated the cytotoxic and antiproliferative efficacy of two well-characterized members of the Cecropin-family of antimicrobial peptides against bladder tumor cells and benign fibroblasts.</p> <p>Methods</p> <p>The antiproliferative and cytotoxic potential of the Cecropins A and B was quantified by colorimetric WST-1-, BrdU- and LDH-assays in four bladder cancer cell lines as well as in murine and human fibroblast cell lines. IC₅₀values were assessed by logarithmic extrapolation, representing the concentration at which cell viability was reduced by 50%. Scanning electron microscopy (SEM) was performed to visualize the morphological changes induced by Cecropin A and B in bladder tumor cells and fibroblasts.</p> <p>Results</p> <p>Cecropin A and B inhibit bladder cancer cell proliferation and viability in a dose-dependent fashion. The average IC₅₀values of Cecropin A and B against all bladder cancer cell lines ranged between 73.29 μg/ml and 220.05 μg/ml. In contrast, benign fibroblasts were significantly less or not at all susceptible to Cecropin A and B. Both Cecropins induced an increase in LDH release from bladder tumor cells whereas benign fibroblasts were not affected. SEM demonstrated lethal membrane disruption in bladder cancer cells as opposed to fibroblasts.</p> <p>Conclusion</p> <p>Cecropin A and B exert selective cytotoxic and antiproliferative efficacy in bladder cancer cells while sparing targets of benign murine or human fibroblast origin. Both peptides may offer novel therapeutic strategies for the treatment of bladder cancer with limited cytotoxic effects on benign cells.</p