Library 2.0 or Library III : returning to leadership

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Just how difficult can it be counting up R&D funding for emerging technologies (and is tech mining with proxy measures going to be any better?)

Decision makers considering policy or strategy related to the development of emerging technologies expect high quality data on the support for different technological options. A natural starting point would be R&D funding statistics. This paper explores the limitations of such aggregated data in relation to the substance and quantification of funding for emerging technologies. Using biotechnology as an illustrative case, we test the utility of a novel taxonomy to demonstrate the endemic weaknesses in the availability and quality of data from public and private sources. Using the same taxonomy, we consider the extent to which tech-mining presents an alternative, or potentially complementary, way to determine support for emerging technologies using proxy measures such as patents and scientific publications

What is the role of public feeder markets in developing technology-based small firms? An exploration of the motivations for listing on AIM since the GFC

In the aftermath of the 2007 global financial crisis (GFC) stock markets experienced sharp decline in listings and marked reduction in Initial Public Offerings (IPOs). This paper explores the factors determining UK technology based small firm (TBSF) listings on the UK Alternative Investment Market (AIM) and whether this market has a role to play in their future development. A case study approach is used to contrast the experiences of five recent AIM listed TBSFs with five TBSFs approaching private equity investment exit that are considering an IPO. The paper concludes that macro market conditions, rather than managerial resource base or AIM market structural factors were most influential in TBSF pecking order preferences to undertake IPOs. From a resource based management perspective lifelong entrepreneurs were more likely than serial entrepreneurs to favour an IPO exit, as it supported their aims to continue to manage and grow UK-based companies. Additionally, with a more buoyant and sustainable AIM market TBSF investors are more likely to choose IPOs. To conclude, AIM played an important role in listed UK TBSF development. A more buoyant AIM could ease the UK finance escalator’s flow, facilitating more rapid UK TBSF growth

Proteomics Characterization of Outer Membrane Vesicles from the Extraintestinal Pathogenic Escherichia coli ΔtolR IHE3034 Mutant

Extraintestinal pathogenic Escherichia coli are the cause of a diverse spectrum of invasive infections in humans and animals, leading to urinary tract infections, meningitis, or septicemia. In this study, we focused our attention on the identification of the outer membrane proteins of the pathogen in consideration of their important biological role and of their use as potential targets for prophylactic and therapeutic interventions. To this aim, we generated a DeltatolR mutant of the pathogenic IHE3034 strain that spontaneously released a large quantity of outer membrane vesicles in the culture supernatant. The vesicles were analyzed by two-dimensional electrophoresis coupled to mass spectrometry. The analysis led to the identification of 100 proteins, most of which are localized to the outer membrane and periplasmic compartments. Interestingly based on the genome sequences available in the current public database, seven of the identified proteins appear to be specific for pathogenic E. coli and enteric bacteria and therefore are potential targets for vaccine and drug development. Finally we demonstrated that the cytolethal distending toxin, a toxin exclusively produced by pathogenic bacteria, is released in association with the vesicles, supporting the recently proposed role of bacterial vesicles in toxin delivery to host cells. Overall, our data demonstrated that outer membrane vesicles represent an ideal tool to study Gram-negative periplasm and outer membrane compartments and to shed light on new mechanisms of bacterial pathogenesis

The Rise of the Resilient Local Authority?

The term resilience is increasingly being utilised within the study of public policy to depict how individuals, communities and organisations can adapt, cope, and ‘bounce back’ when faced with external shocks such as climate change, economic recession and cuts in public expenditure. In focussing on the local dimensions of the resilience debate, this article argues that the term can provide useful insights into how the challenges facing local authorities in the UK can be reformulated and reinterpreted. The article also distinguishes between resilience as ‘recovery’ and resilience as ‘transformation’, with the latter's focus on ‘bouncing forward’ from external shocks seen as offering a more radical framework within which the opportunities for local innovation and creativity can be assessed and explained. While also acknowledging some of the weaknesses of the resilience debate, the dangers of conceptual ‘stretching’, and the extent of local vulnerabilities, the article highlights a range of examples where local authorities – and crucially, local communities – have enhanced their adaptive capacity, within existing powers and responsibilities. From this viewpoint, some of the barriers to the development of resilient local government are not insurmountable, and can be overcome by ‘digging deep’ to draw upon existing resources and capabilities, promoting a strategic approach to risk, exhibiting greater ambition and imagination, and creating space for local communities to develop their own resilience

The spatial footprint of the knowledge economy: the role of intangible investment in shaping regional inequalities in Great Britain

Since the advent of the knowledge economy it has become evident that the territorial footprint of investment in intangible assets is largely asymmetrical. First, these types of assets tend to be distributed unevenly across space. Second, intangible assets are an important source of productivity growth and competitiveness. Although significant advances have been made in measuring intangible assets and accounting for their effects in economic outcomes, their exact nature remains vague. Within the National Accounts framework the majority of intangibles are, even now, still treated as intermediate expenditure. Consequently, intangibles are largely excluded from conventional measures of output and investment, making it difficult to account for their spatial effects. The present paper adjusts Gross Value Added (GVA) data for NUTS3 regions in Great Britain for intangibles. The adjusted series are then used to investigate trends in regional inequalities in GVA per employee in this country during the pre-recession period 1995-2007

Governing software: networks, databases and algorithmic power in the digital governance of public education

This article examines the emergence of ‘digital governance’ in public education in England. Drawing on and combining concepts from software studies, policy and political studies, it identifies some specific approaches to digital governance facilitated by network-based communications and database-driven information processing software that are being discursively promoted in education by cross-sectoral intermediary organizations. Such intermediaries, including National Endowment for Science, Technology and the Arts, Demos, the Innovation Unit, the Education Foundation and the Nominet Trust, are increasingly seeking to participate in new digitally mediated forms of educational governance. Through their promotion of network-based pedagogies and database-driven analytics software, these organizations are seeking to delegate educational decision-making to socio-algorithmic forms of power that have the capacity to predict, govern and activate learners' capacities and subjectivities

A "novel" reading therapy programme for reading difficulties after a subarachnoid haemorrhage

Background: Although several treatments for acquired reading difficulties exist, few studies have explored the effectiveness of treatment for mild reading difficulties and treatment for reading difficulties associated with cognitive impairment. Aims: This study explored the effectiveness of an individual strategy-based reading treatment of 11 sessions given to a female participant (IW) who had mild reading difficulties following a subarachnoid haemorrhage (SAH). The impact of treatment on reading ability, confidence and emotions associated with reading were investigated. Methods & Procedures: Treatment focussed on the use of strategies to support IW’s memory when reading books, the use of a checklist to select appropriate reading materials, and increasing IW’s confidence in discussing the book she was reading with others. A person-centred approach and personally relevant materials were used throughout the treatment. Reading ability was assessed using the Gray Oral Reading Tests (GORT-4; Lee Wiederholt & Bryant, 2001), and IW’s perspective was obtained using the Reading Confidence and Emotions Questionnaire (RCEQ; see Cocks et al., 2010. Pre-treatment, post-treatment and maintenance (7 weeks post) assessments were undertaken, with an additional exit interview at the final time point. Outcomes & Results: Gains were noted in reading rate, accuracy, comprehension, and confidence, with parallel increased pleasure gained from reading and reduced negative emotions and frustration. Self-reported gains included conversing with others about material read, verbal communication, and re-engagement with the identity of being a reader. Conclusions: Strategy-based treatment resulted in positive gains in reading for pleasure, conversation, and identity, for an individual with mild chronic reading difficulties. Participant self-report and interview reveal the true value of this treatment for the individual. The positive results suggest that further research is warranted that investigates the effectiveness of strategy-based reading therapy approaches for others with acquired reading difficulties