363 research outputs found
Semi-device-independent bounds on entanglement
Detection and quantification of entanglement in quantum resources are two key
steps in the implementation of various quantum-information processing tasks.
Here, we show that Bell-type inequalities are not only useful in verifying the
presence of entanglement but can also be used to bound the entanglement of the
underlying physical system. Our main tool consists of a family of
Clauser-Horne-like Bell inequalities that cannot be violated maximally by any
finite-dimensional maximally entangled state. Using these inequalities, we
demonstrate the explicit construction of both lower and upper bounds on the
concurrence for two-qubit states. The fact that these bounds arise from
Bell-type inequalities also allows them to be obtained in a
semi-device-independent manner, that is, with assumption of the dimension of
the Hilbert space but without resorting to any knowledge of the actual
measurements being performed on the individual subsystems.Comment: 8 pages, 2 figures (published version). Note 1: Title changed to
distinguish our approach from the standard device-independent scenario where
no assumption on the Hilbert space dimension is made. Note 2: This paper
contains explicit examples of more nonlocality with less entanglement in the
simplest CH-like scenario (see also arXiv:1011.5206 by Vidick and Wehner for
related results
17.4 Efficient in vivo gene delivery using chitosan/DNA nanoparticles for applications in cartilage repair
P32 Interspecies comparison of meniscus properties in human, sheep and rabbit and development of animal models for meniscus repair
Dynamic Interpretation of Hedgehog Signaling in the Drosophila Wing Disc
Morphogens are classically defined as molecules that control patterning by acting at a distance to regulate gene expression in a concentration-dependent manner. In the Drosophila wing imaginal disc, secreted Hedgehog (Hh) forms an extracellular gradient that organizes patterning along the anterior–posterior axis and specifies at least three different domains of gene expression. Although the prevailing view is that Hh functions in the Drosophila wing disc as a classical morphogen, a direct correspondence between the borders of these patterns and Hh concentration thresholds has not been demonstrated. Here, we provide evidence that the interpretation of Hh signaling depends on the history of exposure to Hh and propose that a single concentration threshold is sufficient to support multiple outputs. Using mathematical modeling, we predict that at steady state, only two domains can be defined in response to Hh, suggesting that the boundaries of two or more gene expression patterns cannot be specified by a static Hh gradient. Computer simulations suggest that a spatial “overshoot” of the Hh gradient occurs, i.e., a transient state in which the Hh profile is expanded compared to the Hh steady-state gradient. Through a temporal examination of Hh target gene expression, we observe that the patterns initially expand anteriorly and then refine, providing in vivo evidence for the overshoot. The Hh gene network architecture suggests this overshoot results from the Hh-dependent up-regulation of the receptor, Patched (Ptc). In fact, when the network structure was altered such that the ptc gene is no longer up-regulated in response to Hh-signaling activation, we found that the patterns of gene expression, which have distinct borders in wild-type discs, now overlap. Our results support a model in which Hh gradient dynamics, resulting from Ptc up-regulation, play an instructional role in the establishment of patterns of gene expression
Quantum networks reveal quantum nonlocality
The results of local measurements on some composite quantum systems cannot be
reproduced classically. This impossibility, known as quantum nonlocality,
represents a milestone in the foundations of quantum theory. Quantum
nonlocality is also a valuable resource for information processing tasks, e.g.
quantum communication, quantum key distribution, quantum state estimation, or
randomness extraction. Still, deciding if a quantum state is nonlocal remains a
challenging problem. Here we introduce a novel approach to this question: we
study the nonlocal properties of quantum states when distributed and measured
in networks. Using our framework, we show how any one-way entanglement
distillable state leads to nonlocal correlations. Then, we prove that
nonlocality is a non-additive resource, which can be activated. There exist
states, local at the single-copy level, that become nonlocal when taking
several copies of it. Our results imply that the nonlocality of quantum states
strongly depends on the measurement context.Comment: 4 + 3 pages, 4 figure
SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron
We address whether T cell responses induced by different vaccine platforms (mRNA-1273, BNT162b2, Ad26.COV2.S, and NVX-CoV2373) cross-recognize early SARS-CoV-2 variants. T cell responses to early variants were preserved across vaccine platforms. By contrast, significant overall decreases were observed for memory B cells and neutralizing antibodies. In subjects 3c6 months post-vaccination, 90% (CD4+) and 87% (CD8+) of memory T cell responses were preserved against variants on average by AIM assay, and 84% (CD4+) and 85% (CD8+) preserved against Omicron. Omicron RBD memory B cell recognition was substantially reduced to 42% compared with other variants. T cell epitope repertoire analysis revealed a median of 11 and 10 spike epitopes recognized by CD4+ and CD8+ T cells, with average preservation > 80% for Omicron. Functional preservation of the majority of T cell responses may play an important role as a second-level defense against diverse variants
Entanglement in Many-Body Systems
The recent interest in aspects common to quantum information and condensed
matter has prompted a prosperous activity at the border of these disciplines
that were far distant until few years ago. Numerous interesting questions have
been addressed so far. Here we review an important part of this field, the
properties of the entanglement in many-body systems. We discuss the zero and
finite temperature properties of entanglement in interacting spin, fermionic
and bosonic model systems. Both bipartite and multipartite entanglement will be
considered. At equilibrium we emphasize on how entanglement is connected to the
phase diagram of the underlying model. The behavior of entanglement can be
related, via certain witnesses, to thermodynamic quantities thus offering
interesting possibilities for an experimental test. Out of equilibrium we
discuss how to generate and manipulate entangled states by means of many-body
Hamiltonians.Comment: 61 pages, 29 figure
Phosphine-Catalyzed Formation of Carbon-Sulfur Bonds: Catalytic Asymmetric Synthesis of gamma-Thioesters
Supporting Information Available: Experimental procedures and compound characterization data. This material is available free of charge via the Internet at http://pubs.acs.org.A method for catalytic asymmetric γ sulfenylation of carbonyl compounds has been developed. In the presence of an appropriate catalyst, thiols not only add to the γ position of allenoates, overcoming their propensity to add to the β position in the absence of a catalyst, but do so with very good enantioselectivity. Sulfur nucleophiles are now added to the three families of nucleophiles (carbon, nitrogen, and oxygen) that had earlier been shown to participate in catalyzed γ additions. The phosphine catalyst of choice, TangPhos, had previously only been employed as a chiral ligand for transition metals, not as an efficient enantioselective nucleophilic catalyst.National Institutes of Health (U.S.)National Institute of General Medical Sciences (U.S.) (R01-GM57034)Merck & Co.Novartis (Firm
CSN-mediated deneddylation differentially modulates Ci155 proteolysis to promote Hedgehog signalling responses
The Hedgehog (Hh) morphogen directs distinct cell responses according to its distinct signalling levels. Hh signalling stabilizes transcription factor cubitus interruptus (Ci) by prohibiting SCFSlimb-dependent ubiquitylation and proteolysis of Ci. How graded Hh signalling confers differential SCFSlimb-mediated Ci proteolysis in responding cells remains unclear. Here, we show that in COP9 signalosome (CSN) mutants, in which deneddylation of SCFSlimb is inactivated, Ci is destabilized in low-to-intermediate Hh signalling cells. As a consequence, expression of the low-threshold Hh target gene dpp is disrupted, highlighting the critical role of CSN deneddylation on low-to-intermediate Hh signalling response. The status of Ci phosphorylation and the level of E1 ubiquitin-activating enzyme are tightly coupled to this CSN regulation. We propose that the affinity of substrate–E3 interaction, ligase activity and E1 activity are three major determinants for substrate ubiquitylation and thereby substrate degradation in vivo
Characterization of Fluorescent Eye Markers for Mammalian Transgenic Studies
Genotyping mice by DNA based methods is both laborious and costly. As an alternative, we systematically examined fluorescent proteins expressed in the lens as transgenic markers for mice. A set of eye markers has been selected such that double and triple transgenic animals can be visually identified and that fluorescence intensity in the eyes can be used to distinguish heterozygous from homozygous mice. Taken together, these eye markers dramatically reduce the time and cost of genotyping transgenics and empower analysis of genetic interaction
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