Development and piloting of a treatment foster care program for older youth with psychiatric problems

BACKGROUND: Older youth in out-of-home care often live in restrictive settings and face psychiatric issues without sufficient family support. This paper reports on the development and piloting of a manualized treatment foster care program designed to step down older youth with high psychiatric needs from residential programs to treatment foster care homes. METHODS: A team of researchers and agency partners set out to develop a treatment foster care model for older youth based on Multi-dimensional Treatment Foster Care (MTFC). After matching youth by mental health condition and determining for whom randomization would be allowed, 14 youth were randomized to treatment as usual or a treatment foster home intervention. Stakeholders were interviewed qualitatively at multiple time points. Quantitative measures assessed mental health symptoms, days in locked facilities, employment and educational outcomes. RESULTS: Development efforts led to substantial variations from the MTFC model and a new model, Treatment Foster Care for Older Youth was piloted. Feasibility monitoring suggested that it was difficult, but possible to recruit and randomize youth from and out of residential homes and that foster parents could be recruited to serve them. Qualitative data pointed to some qualified clinical successes. Stakeholders viewed two team roles – that of psychiatric nurse and skills coaches – very highly. However, results also suggested that foster parents and some staff did not tolerate the intervention well and struggled to address the emotion dysregulation issues of the young people they served. Quantitative data demonstrated that the intervention was not keeping youth out of locked facilities. CONCLUSIONS: The intervention needed further refinement prior to a broader trial. Intervention development work continued until components were developed to help address emotion regulation problems among fostered youth. Psychiatric nurses and skills coaches who work with youth in community settings hold promise as important supports for older youth with psychiatric needs

Quantum incompressibility of a falling Rydberg atom, and a gravitationally-induced charge separation effect in superconducting systems

Freely falling point-like objects converge towards the center of the Earth. Hence the gravitational field of the Earth is inhomogeneous, and possesses a tidal component. The free fall of an extended quantum object such as a hydrogen atom prepared in a high principal-quantum-number stretch state, i.e., a circular Rydberg atom, is predicted to fall more slowly that a classical point-like object, when both objects are dropped from the same height from above the Earth. This indicates that, apart from "quantum jumps," the atom exhibits a kind of "quantum incompressibility" during free fall in inhomogeneous, tidal gravitational fields like those of the Earth. A superconducting ring-like system with a persistent current circulating around it behaves like the circular Rydberg atom during free fall. Like the electronic wavefunction of the freely falling atom, the Cooper-pair wavefunction is "quantum incompressible." The ions of the ionic lattice of the superconductor, however, are not "quantum incompressible," since they do not possess a globally coherent quantum phase. The resulting difference during free fall in the response of the nonlocalizable Cooper pairs of electrons and the localizable ions to inhomogeneous gravitational fields is predicted to lead to a charge separation effect, which in turn leads to a large repulsive Coulomb force that opposes the convergence caused by the tidal, attractive gravitational force on the superconducting system. A "Cavendish-like" experiment is proposed for observing the charge separation effect induced by inhomogeneous gravitational fields in a superconducting circuit. This experiment would demonstrate the existence of a novel coupling between gravity and electricity via macroscopically coherent quantum matter.Comment: `2nd Vienna Symposium for the Foundations of Modern Physics' Festschrift MS for Foundations of Physic

The effect of increasing physical activity and/or omega-3 supplementation on fatigue in inflammatory bowel disease

Objective: Fatigue is frequently reported by patients with inflammatory bowel disease (IBD), irrespective of disease activity; however, evidence regarding fatigue management is limited. This study tested the effect of individualised advice to increase physical activity and/or omega-3 fatty acids supplementation, on IBD-related fatigue. Methods: A pilot study in patients with inactive IBD, utilising a randomised controlled 2x2 factorial design (four groups) compared baseline and post-intervention fatigque scores. Study interventions: individualised exercise advice (15 minute consultation) and/or supplementation (omega-3 fatty acids, 2970mg/day) for 12 weeks. Control interventions: general health discussion and/or placebo supplement. All patients received follow-up support. Primary outcome was fatigue measured by Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale score; secondary outcomes included change in Inflammatory Bowel Disease-Fatigue (IBD-F) scale score. Results: From n=656 screened patients, n=74 who met the selection criteria were randomised, n=60 commenced, and n=52 completed the study. Fatigue as tThe primary outcome fatigque, measured with FACIT-F, showed slight worsening in the omega-3 supplementation group (95%CI:-8.6-(-0.7);p=0.02), and no change in the exercise advice group (p=0.38). Reduced fatigue, measured by IBD-F score, was identified in the exercise group (95%CI:-3.8-(-0.2);p=0.03). One treatment-related adverse event (musculoskeletal pain) was reported with exercise. Conclusions: Advice to increase physical activity and omega-3 supplementation, singly or in combination, were shown to be safe and generally well-tolerated. There was no evidence of exercise-related adverse effects on gut-related symptoms, and some evidence of improvement in fatigue. The slight worsening of fatigue with omega-3 supplementation is unexplained. Regular moderate to -vigorous exercise may be a self-management option in IBD-related fatigue

The role of religion in the longer-range future, April 6, 7, and 8, 2006

This repository item contains a single issue of the Pardee Conference Series, a publication series that began publishing in 2006 by the Boston University Frederick S. Pardee Center for the Study of the Longer-Range Future. This conference that took place during April 6, 7, and 8, 2006. Co-organized by David Fromkin, Director, Frederick S. Pardee Center for the Study of the Longer-Range Future, and Ray L. Hart, Dean ad interim Boston University School of TheologyThe conference brought together some 40 experts from various disciplines to ponder upon the “great dilemma” of how science, religion, and the human future interact. In particular, different panels looked at trends in what is happening to religion around the world, questions about how religion is impacting the current political and economic order, and how the social dynamics unleashed by science and by religion can be reconciled.Carnegie Council on Ethics and International Affair

A thermal-optical analysis of a compound parabolic concentrator for single and multiphase flows, including superheat

A thermal and optical analysis of the performance of a refrigerant charged Compound Parabolic Concentrator (CPC) for solar applications operating in non-boiling, boiling and super-heated regimes is presented. The performance of the CPC working under these single and multiphase conditions is governed by the axial fractional channel lengths of the non-boiling and the superheating regions. The overall thermal loss coefficient, the dimensionless capacitance rate and collector efficiency factors for various CPC operating regions are defined. A new “Generalized Heat Removal Factor“, ℱ s for solar collectors under any operation mode is developed. The thermal efficiency of a CPC and flat-plate collector, whether under non-boiling, boiling or superheated conditions, is evaluated using ℱ s which enables the selection of a suitable collector design and concentration ratio at some specified operational temperature. It is shown that, in general, a CPC has a greater thermal conversion efficiency than a flat-plate for a given operating condition. Es wird eine thermische und optische Analyse des Verhaltens eines Verbund-Parabol-Kollektors für die Anwendung der Sonnenenergie vorgestellt, der mit Kältemittel im nichtsiedenden, und übehitzten Bereich arbeitet. Das Verhalten dieses unter ein- und mehrphasigen Bedingungen arbeitenden Kollektors wird bestimmt durch den axialen Anteil der Kühl-kanallängen im nichtsiedenden und im überhitzten Zustand. Es werden der mittlere thermische Verlustkoeffizient, die dimensionslose Wärmekapazität sowie die Kollektorwirkungsgrade für verschiedene Zustandsbereiche dieses Parabolspiegels definiert. Ein neuer „verallgemeinerter Wärmeabflußfaktor“, ℱ s , für Sonnenkollektoren, die unter beliebigen Betriebsbedingungen arbeiten, wurde entwickelt. Mit diesem ℱ s Faktor werden der thermische Wirkungsgrad des Parabolkollektors und eines Platten-kollektors bei einphasiger flüssiger Strömung beim Sieden und für überhitzten Dampf berechnet, wodurch es möglich wird, eine geeignete Kollektorauslegung und das dazugehörige Konzentrationsverhältnis bei vorgegebenen Betriebstemperaturen zu wählen. Es wird gezeigt, daß im allgemeinen der parabolische Kollektor einen höheren thermischen Wirkungsgrad besitzt als der Platten-kollektor bei identischen Betriebsbedingungen.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46656/1/231_2005_Article_BF01377577.pd

Prostate response to prolactin in sexually active male rats

BACKGROUND: The prostate is a key gland in the sexual physiology of male mammals. Its sensitivity to steroid hormones is widely known, but its response to prolactin is still poorly known. Previous studies have shown a correlation between sexual behaviour, prolactin release and prostate physiology. Thus, here we used the sexual behaviour of male rats as a model for studying this correlation. Hence, we developed experimental paradigms to determine the influence of prolactin on sexual behaviour and prostate organization of male rats. METHODS: In addition to sexual behaviour recordings, we developed the ELISA procedure to quantify the serum level of prolactin, and the hematoxilin-eosin technique for analysis of the histological organization of the prostate. Also, different experimental manipulations were carried out; they included pituitary grafts, and haloperidol and ovine prolactin treatments. Data were analyzed with a One way ANOVA followed by post hoc Dunnet test if required. RESULTS: Data showed that male prolactin has a basal level with two peaks at the light-dark-light transitions. Consecutive ejaculations increased serum prolactin after the first ejaculation, which reached the highest level after the second, and started to decrease after the third ejaculation. These normal levels of prolactin did not induce any change at the prostate tissue. However, treatments for constant elevations of serum prolactin decreased sexual potency and increased the weight of the gland, the alveoli area and the epithelial cell height. Treatments for transient elevation of serum prolactin did not affect the sexual behaviour of males, but triggered these significant effects mainly at the ventral prostate. CONCLUSION: The prostate is a sexual gland that responds to prolactin. Mating-induced prolactin release is required during sexual encounters to activate the epithelial cells in the gland. Here we saw a precise mechanism controlling the release of prolactin during ejaculations that avoid the detrimental effects produced by constant levels. However, we showed that minor elevations of prolactin which do not affect the sexual behaviour of males, produced significant changes at the prostate epithelium that could account for triggering the development of hyperplasia or cancer. Thus, it is suggested that minute elevations of serum prolactin in healthy subjects are at the etiology of prostate abnormal growth

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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