The autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism

Autism spectrum disorders (ASDs) represent a formidable challenge for psychiatry and neuroscience because of their high prevalence, lifelong nature, complexity and substantial heterogeneity. Facing these obstacles requires large-scale multidisciplinary efforts. Although the field of genetics has pioneered data sharing for these reasons, neuroimaging had not kept pace. In response, we introduce the Autism Brain Imaging Data Exchange (ABIDE)—a grassroots consortium aggregating and openly sharing 1112 existing resting-state functional magnetic resonance imaging (R-fMRI) data sets with corresponding structural MRI and phenotypic information from 539 individuals with ASDs and 573 age-matched typical controls (TCs; 7–64 years) (http://fcon_1000.projects.nitrc.org/indi/abide/). Here, we present this resource and demonstrate its suitability for advancing knowledge of ASD neurobiology based on analyses of 360 male subjects with ASDs and 403 male age-matched TCs. We focused on whole-brain intrinsic functional connectivity and also survey a range of voxel-wise measures of intrinsic functional brain architecture. Whole-brain analyses reconciled seemingly disparate themes of both hypo- and hyperconnectivity in the ASD literature; both were detected, although hypoconnectivity dominated, particularly for corticocortical and interhemispheric functional connectivity. Exploratory analyses using an array of regional metrics of intrinsic brain function converged on common loci of dysfunction in ASDs (mid- and posterior insula and posterior cingulate cortex), and highlighted less commonly explored regions such as the thalamus. The survey of the ABIDE R-fMRI data sets provides unprecedented demonstrations of both replication and novel discovery. By pooling multiple international data sets, ABIDE is expected to accelerate the pace of discovery setting the stage for the next generation of ASD studies

Vision Transformers with Natural Language Semantics

Tokens or patches within Vision Transformers (ViT) lack essential semantic information, unlike their counterparts in natural language processing (NLP). Typically, ViT tokens are associated with rectangular image patches that lack specific semantic context, making interpretation difficult and failing to effectively encapsulate information. We introduce a novel transformer model, Semantic Vision Transformers (sViT), which leverages recent progress on segmentation models to design novel tokenizer strategies. sViT effectively harnesses semantic information, creating an inductive bias reminiscent of convolutional neural networks while capturing global dependencies and contextual information within images that are characteristic of transformers. Through validation using real datasets, sViT demonstrates superiority over ViT, requiring less training data while maintaining similar or superior performance. Furthermore, sViT demonstrates significant superiority in out-of-distribution generalization and robustness to natural distribution shifts, attributed to its scale invariance semantic characteristic. Notably, the use of semantic tokens significantly enhances the model's interpretability. Lastly, the proposed paradigm facilitates the introduction of new and powerful augmentation techniques at the token (or segment) level, increasing training data diversity and generalization capabilities. Just as sentences are made of words, images are formed by semantic objects; our proposed methodology leverages recent progress in object segmentation and takes an important and natural step toward interpretable and robust vision transformers.Comment: 22 pages, 9 figure

What works to boost social relations and community wellbeing? A scoping review of the evidence

Background: Social relations are recognized as an important determinant of individual & community wellbeing. The UK What Works Wellbeing Centre chose “boosting social relations” as a priority topic for systematic review. First, a scoping review was undertaken to identify evidence gaps. Methods: We searched: Cochrane database of systematic reviews, DARE, Campbell Library, DoPHER (EPPI-Centre), Joanne Briggs Institute, MEDLINE, IDOX, CINAHL, PsycINFO, Social Policy & Practice, Social Care Online; relevant websites. Inclusion criteria: Population – communities in OECD countries; Intervention - Any community-based intervention, change in policy, organisation or environment that were designed to boost social relations within the community; Outcomes – social relations, community wellbeing or related synonyms; Study design – systematic & non-systematic reviews published between 2005 and 2016. Studies were selected & data extracted by 3 reviewers, and summarised narratively. Results: 11,257 titles and abstracts were screened, 182 obtained in full & 29 included. Existing evidence tells us: Targeted group interventions that foster social networks & provide meaningful roles can reduce social isolation and/ or loneliness in older people; Volunteering can improve physical & mental health & wellbeing in older people; Effective community engagement produces sustainable improvements in community health & individual wellbeing. Evidence gaps: Interventions for social isolation &/ or loneliness in adults aged up to 65 years; Volunteering in people aged up to 65 years; Social network analyses; Community infrastructure (places & spaces). Stakeholder consultations identified community infrastructure (places & spaces) as the most useful topic for systematic review. Conclusions: A systematic scoping review of reviews, with stakeholder consultation, identified community infrastructure (places & spaces) as an evidence gap. Early findings from the resulting systematic review will be presented

Epiphytic lichens of the sacred natural site "Bosco di Sant'Antonio" (Majella National Park - Abruzzo)

Sacred Natural Sites are relevant for biodiversity conservation, as in the case of forest sites that, across centuries, developed old growth structures and are now crucial for the conservation of epiphytic lichens and other specialized forest organisms. In this study, we investigated the epiphytic lichen flora of a small forest patch included in the Majella National Park (Abruzzo), whose old growth features and naturalness reflect its long lasting spiritual role that perfectly fits with the concept of Sacred Natural Site. Results revealed that the "Bosco di Sant'Antonio" hosts a rich and interesting epiphytic lichen flora, thus indicating the potential of this Sacred Natural Site for lichen conservation. Fifty-six species were found including two species newly recorded in Abruzzo, two red-listed species, and the sensitive species Lobaria pulmonaria. This study corroborates the hypothesis that sacred forest sites are relevant for the conservation of specialized epiphytic lichens. In particular, in the Italian forest landscape where old-growth stands are practically absent, sacred forest sites may provide unique old-growth structures and buffer anthropogenic disturbance

Structure-Based Mechanism for Early PLP-Mediated Steps of Rabbit Cytosolic Serine Hydroxymethyltransferase Reaction

Serine hydroxymethyltransferase catalyzes the reversible interconversion of L-serine and glycine with transfer of one-carbon groups to and from tetrahydrofolate. Active site residue Thr254 is known to be involved in the transaldimination reaction, a crucial step in the catalytic mechanism of all pyridoxal 5′-phosphate- (PLP-) dependent enzymes, which determines binding of substrates and release of products. In order to better understand the role of Thr254, we have expressed, characterized, and determined the crystal structures of rabbit cytosolic serine hydroxymethyltransferase T254A and T254C mutant forms, in the absence and presence of substrates. These mutants accumulate a kinetically stable gem-diamine intermediate, and their crystal structures show differences in the active site with respect to wild type. The kinetic and crystallographic data acquired with mutant enzymes permit us to infer that conversion of gem-diamine to external aldimine is significantly slowed because intermediates are trapped into an anomalous position by a misorientation of the PLP ring, and a new energy barrier hampers the transaldimination reaction. This barrier likely arises from the loss of the stabilizing hydrogen bond between the hydroxymethyl group of Thr254 and the ε-amino group of active site Lys257, which stabilizes the external aldimine intermediate in wild type SHMTs

Maternal Smoking Evaluation Report

One You Leeds provides the maternal stop smoking service across the city of Leeds. Staff from the Centre for Health Promotion Research were commissioned to evaluate the service, between March 2018-June 2019

A systematic review of interventions to boost social relations through improvements in community infrastructure (places and spaces)

The aim of this systematic review is to synthesise the available evidence, and describe the quality of that evidence, in relation to interventions that improve or create the community infrastructure that impacts on social relations and/ or community wellbeing. For this review, we are defining community infrastructure as the physical places and spaces where people can come together, formally or informally, to interact and participate in the social life of the community. We intend to produce a synthesis which is accessible and will inform practice and future research in the area