Prevalence of sleep apnoea in patients with chronic kidney disease (CKD) receiving renal replacement therapy by haemodialysis

Background. Sleep disorders in kidney disease patients occur more frequently than in the general population. Chronic renal disease patients are commonly diagnosed with sleep apnoea syndrome. It occurs in the obstructive, central and mixed form and is of multicausal nature. The aim of the present paper was to assess the frequency of individual types of sleep-related breathing disorders in chronically haemodialysed patients using polysomnography. Material and methods. The study involved stage 5 CKD patients receiving continuous renal replacement therapy by haemodialysis. Results. The obtained results suggest that weight gain between consecutive haemodialysis sessions correlates with more frequent occurrences of disordered breathing events (apnoeas and hypopnoeas) in patients on the night preceding haemodialysis session. Conclusions. Positive linear correlations are observed of systolic and diastolic BP measured before PSG performed on the day before a haemodialysis session with the number of snoring episodes, which might suggest that breathing disorders affect the complex pathogenesis of hypertension in haemodialysed patients

Profilaktyczny program wczesnego rozpoznawania przewlekłej choroby nerek- akcja „Uwaga Nerki”- Bydgoszcz 2010.

Chronic kidney disease (CKD) is a significant health problem in Poland and all over the world. It is estimated that in Poland CKD affects more than 4 million people (it is about 10-13% of the Polish population). Early detection of CKD is of great importance because of the possibility of an effective therapy to protect kidney function especially in patients with high risk of developing CKD. The aim of the study was to analyze the results of the program for early detection of kidney disease conducted in Bydgoszcz in 2010. 347 subjects took part in preventive action of early detection of kidney disease. They underwent free laboratory tests:urinalysis, serum creatinine level, eGFR calculation. Moreover, in each patient’s blood pressure was measured. Besides laboratory tests results, all patients were given comprehensive information concerning further nephrological management. 347 people were evaluated in this local Preventive Program of  Early CKD detection. There were two fold more women than       men. The largest group among the respondents were people aged between 50 and 70 years of age, in stage 2 (63.1%, GFR> 60 ml/min) and 3-stage kidney disease (31.4%, eGFR <60 ml /min).      Przewlekła choroba nerek (PChN) stanowi znaczący problem zdrowotny w Polsce i na świecie. Szacuje się, że w  Polsce na choroby nerek choruje ponad 4 mln osób co stanowi ok. 10-13% społeczeństwa. Wczesne wykrywanie PChN  ma ogromne znaczenie dla możliwości podjęcia skutecznej  terapii, mającej na celu ochronę funkcji nerek zwłaszcza w  grupach wysokiego ryzyka rozwoju PChN.  Celem przedstawionej pracy jest analiza wyników programu wczesnego wykrywania chorób nerek przeprowadzonego na terenie Bydgoszczy w roku 2010. W programie profilaktycznym udział wzięło 347 osób, którym wykonano badanie ogólne moczu, oznaczono stężenie kreatyniny, wyliczono eGFR oraz zmierzono ciśnienie tętnicze. Pacjentom wydano ulotki informacyjne na temat dalszego postępowania po uzyskaniu wyników badań laboratoryjnych. Na badania profilaktyczne zgłosiło się 347 osób, dwukrotnie więcej kobiet niż mężczyzn, najliczniejszą grupę stanowiły osoby w wieku pomiędzy 50 a 70 rokiem życia. Najliczniejszą  grupę stanowili badani w stadium 2 (63,1%, GFR> 60 ml/min)   i w stadium 3 PChN (31.4%, eGFR <60 ml / min).      

The Impact of Fructose on Renal Function and Blood Pressure

Fructose is a sugar present in sucrose, high-fructose corn syrup, honey, and fruits. Fructose intake has increased markedly in the last two centuries, primarily due to increased intake of added sugars. Increasing evidence suggests that the excessive intake of fructose may induce fatty liver, insulin resistance, dyslipidemia, hypertension, and kidney disease. These studies suggest that excessive intake of fructose might have an etiologic role in the epidemic of obesity, diabetes, and cardiorenal disease

Preventive program of early detection of chronic kidney disease. Action “Warning Kidney”- Bydgoszcz 2010.

Chronic kidney disease (CKD) is a significant health problem in Poland and all over the world. It is estimated that in Poland CKD affects more than 4 million people (it is about 10-13% of the Polish population). Early detection of CKD is of great importance because of the possibility of an effective therapy to protect kidney function especially in patients with high risk of developing CKD. The aim of the study was to analyze the results of the program for early detection of kidney disease conducted in Bydgoszcz in 2010. 347 subjects took part in preventive action of early detection of kidney disease. They underwent free laboratory tests:urinalysis, serum creatinine level, eGFR calculation. Moreover, in each patient’s blood pressure was measured. Besides laboratory tests results, all patients were given comprehensive information concerning further nephrological management. 347 people were evaluated in this local Preventive Program of Early CKD detection. There were two fold more women than men. The largest group among the respondents were people aged between 50 and 70 years of age, in stage 2 (63.1%, GFR> 60 ml/min) and 3-stage kidney disease (31.4%, eGFR 60 ml/min) i w stadium 3 PChN (31.4%, eGFR <60 ml / min)

New Perspectives in Sinographic Language Processing Through the Use of Character Structure

Chinese characters have a complex and hierarchical graphical structure carrying both semantic and phonetic information. We use this structure to enhance the text model and obtain better results in standard NLP operations. First of all, to tackle the problem of graphical variation we define allographic classes of characters. Next, the relation of inclusion of a subcharacter in a characters, provides us with a directed graph of allographic classes. We provide this graph with two weights: semanticity (semantic relation between subcharacter and character) and phoneticity (phonetic relation) and calculate "most semantic subcharacter paths" for each character. Finally, adding the information contained in these paths to unigrams we claim to increase the efficiency of text mining methods. We evaluate our method on a text classification task on two corpora (Chinese and Japanese) of a total of 18 million characters and get an improvement of 3% on an already high baseline of 89.6% precision, obtained by a linear SVM classifier. Other possible applications and perspectives of the system are discussed.Comment: 17 pages, 5 figures, presented at CICLing 201

Częstość występowania bezdechu sennego u pacjentów z przewlekłą chorobą nerek (PChN) leczonych nerkozastępczo hemodializami

Wstęp: Zaburzenia snu występują częściej u pacjentów z chorobami nerek niż w ogólnej populacji. Zespół bezdechu sennego jest częściej diagnozowany u pacjentów z przewlekłą chorobą nerek (PChN). Przybiera on formę obturacyjną, ośrodkową lub mieszaną i ma złożoną etiologię. Celem niniejszej pracy była ocena częstości występowania poszczególnych typów zaburzeń oddychania w trakcie snu przy użyciu polisomnografii u pacjentów długotrwale hemodializowanych. Materiały i metody: Badaniem objęto pacjentów w V stopniu PChN długotrwale leczonych nerkozastępczo metodą hemodializ. Wyniki: Uzyskane wyniki sugerują, że wzrost wagi pacjentów pomiędzy kolejnymi hemodializami koreluje z większą częstością występowania incydentów zaburzeń oddychania w czasie snu (bezdech lub spłycenie oddechu) u pacjentów poddawanych hemodializom. Wnioski: W oparciu o wyniki uzyskane na podstawie przedstawionego badania można wnioskować, że przyrost masy ciała pomiędzy zabiegami hemodializy wiąże się z większą liczbą obserwowanych nieprawidłowych zjawisk oddechowych (bezdechow i spłyceń oddechów) u pacjentów w trakcie nocy poprzedzającej zabieg HD. Ponadto obserwuje się dodatnie korelacje liniowe pomiędzy wartościami RR skurczowego i rozkurczowego zmierzonymi przed badaniem PSG wykonanym w dniu poprzedzającym kolejną hemodializę a liczbą epizodów chrapania, co może sugerować wpływ zaburzeń oddechowych na złożoną patogenezę nadciśnienia tętniczego u chorych hemodializowanych

On exact controllability of linear time delay systems of neutral type

The problem of exact null controllability is considered for linear neutral type systems with distributed delay. A characterization of this problem is given. The minimal time of controllability is precised. The results are based on the analysis of the Riesz basis property of eigenspaces in Hilbert space. Recent results on the moment problem and properties of exponential families are used

Prediction-Based Control of Linear Systems by Compensating Input-Dependent Input Delay of Integral-Type

International audienceThis study addresses the problem of delay compensation via a predictor-based output feedback for a class of linear systems subject to input delay which itself depends on the input. The equation defining the delay is implicit and involves past values of the input through an integral relation, the kernel of which is a polynomial function of the input. This modeling represents systems where transport phenomena take place at the inlet of a system involving a nonlinearity, which frequently occurs in the processing industry. The conditions of asymptotic stabilization require the magnitude of the feedback gain to comply with the initial conditions. Arguments for the proof of this novel result include general Halanay inequalities for delay differential equations and take advantage of recent advances in backstepping techniques for uncertain or varying delay systems