Shear induced breaking of large internal solitary waves

The stability properties of 24 experimentally generated internal solitary waves (ISWs) of extremely large amplitude, all with minimum Richardson number less than 1/4, are investigated. The study is supplemented by fully nonlinear calculations in a three-layer fluid. The waves move along a linearly stratified pycnocline (depth h2) sandwiched between a thin upper layer (depth h1) and a deep lower layer (depth h3), both homogeneous. In particular, the wave-induced velocity profile through the pycnocline is measured by particle image velocimetry (PIV) and obtained in computation. Breaking ISWs were found to have amplitudes (a1) in the range a1>2.24 √h1h2(1+h2/h1), while stable waves were on or below this limit. Breaking ISWs were investigated for 0.27 0.86 and stable waves for Lx/λ < 0.86. The results show a sort of threshold-like behaviour in terms of Lx/λ. The results demonstrate that the breaking threshold of Lx/λ = 0.86 was sharper than one based on a minimum Richardson number and reveal that the Richardson number was found to become almost antisymmetric across relatively thick pycnoclines, with the minimum occurring towards the top part of the pycnoclinePostprintPeer reviewe

A panoramic VISTA of the stellar halo of NGC 253

Outskirts of large galaxies contain important information about the galaxy formation and assembly process, and resolved star count studies can probe the extremely low surface brightness of the outer halos. We use images obtained with the VISTA telescope to construct spatially resolved J vs Z-J colour-magnitude diagrams (CMDs) of NGC 253, a nearly edge-on disk galaxy in the Sculptor group. The very deep photometry, down to J ~ 23.5, and the wide area covered allows us to trace the red giant branch (RGB) and asymptotic giant branch (AGB) stars that belong to the outer disk and the halo of NGC 253, out to 50 kpc along the galaxy minor axis. We confirm the existence of an extra planar stellar component of the disk, with a very prominent southern shelf and a symmetrical feature on the north side. The only additional visible sub-structure is an overdensity in the north-west part of the halo at about 28 kpc from the plane and extending over ~ 20 kpc parallel with the disk of the galaxy. From the stellar count profile along the major axis we measure the transition from the disk to the halo at a radial distance of about 25 kpc, where a clear break appears in the number density profile. The isodensity contours show that the inner halo is a flattened structure that blends with a more extended, diffuse, rounder outer halo. Such external structure can be traced to the very edge of our image out to 50 kpc from the disk plane. The number density profile of the stars in the stellar halo follows a power law with index -1.6, as function of radius. The CMD shows a very homogeneous stellar population across the whole field; by comparison with theoretical isochrones we conclude that the RGB stars are ~ 8 Gyr old or more, while the AGB stars trace a population of about 2 x 10^8 Mo, formed from ~ 0.5 to a few Gyr ago. Surprisingly, part of this latter population appears scattered over a wide area.Comment: To appear on Astronomy and Astrophysic

Self-directed learning in problem-based learning and its relationships with self-regulated learning

This study investigated the role of self-directed learning (SDL) in problem-based learning (PBL) and examined how SDL relates to self-regulated learning (SRL). First, it is explained how SDL is implemented in PBL environments. Similarities between SDL and SRL are highlighted. However, both concepts differ on important aspects. SDL includes an additional premise of giving students a broader role in the selection and evaluation of learning materials. SDL can encompass SRL, but the opposite does not hold. Further, a review of empirical studies on SDL and SRL in PBL was conducted. Results suggested that SDL and SRL are developmental processes, that the "self" aspect is crucial, and that PBL can foster SDL. It is concluded that conceptual clarity of what SDL entails and guidance for both teachers and students can help PBL to bring forth self-directed learners

Structural and dielectric studies of the phase behaviour of the topological ferroelectric La1-xNdxTaO4

We thank the University of St Andrews and EPSRC (via DTG studentships to CALD and JG) for funding,The layered perovskite LaTaO4 has been prepared in its polar orthorhombic polymorphic form at ambient temperature. Although no structural phase transition is observed in the temperature interval 25° C < T < 500 °C, a very large axial thermal contraction effect is seen, which can be ascribed to an anomalous buckling of the perovskite octahedral layer. The non-polar monoclinic polymorph can be stabilised at ambient temperature by Nd-doping. A composition La0.90Nd0.10TaO4 shows a first-order monoclinic-orthorhombic (non-polar to polar) transition in the region 250° C < T < 350 °C. Dielectric responses are observed at both the above structural events but, despite the ‘topological ferroelectric’ nature of orthorhombic LaTaO4, we have not succeeded in obtaining ferroelectric P–E hysteresis behaviour. Structural relationships in the wider family of AnBnX3n+2 layered perovskites are discussed.Publisher PDFPeer reviewe

The edge of the M87 halo and the kinematics of the diffuse light in the Virgo cluster core

We present high resolution FLAMES/VLT spectroscopy of intracluster planetary nebula (ICPN) candidates, targeting three new fields in the Virgo cluster core with surface brightness down to mu_B = 28.5. Based on the projected phase space information we separate the old and 12 newly-confirmed PNs into galaxy and intracluster components. The M87 PNs are confined to the extended stellar envelope of M87, within a projected radius of ~ 160 kpc, while the ICPNs are scattered across the whole surveyed region between M87 and M86. The velocity dispersions determined from the M87 PNs at projected radii of 60 kpc and 144 kpc show that the galaxy's velocity dispersion profile decreases in the outer halo, down to 78 +/- 25 km/s. A Jeans model for the M87 halo stars in the gravitational potential traced by the X-ray emission fits the observed velocity dispersion profile only if the stellar orbits are strongly radially anisotropic (beta ~= 0.4 at r ~= 10 kpc increasing to 0.8 at the outer edge), and if additionally the stellar halo is truncated at ~= 150 kpc average elliptical radius. From the spatial and velocity distribution of the ICPNs we infer that M87 and M86 are falling towards each other and that we may be observing them just before the first close pass. The inferred luminosity-specific PN numbers for the M87 halo and the ICL are in the range of values observed for old (> 10 Gyr) stellar populations (abridged).Comment: Accepted for publication in Astronomy and Astrophysics. 16 pages, 14 figures and 4 table

Routine Activities and Adolescent Deviance across 28 Cultures

Purpose The current study tested the links between routine activities and deviance across twenty-eight countries, thus, the potential generalizability of the routine activities framework. Methods Data were collected as part of the Second International Self-Report Delinquency Study (ISRD-2) from 28 cultures, from seventh, eighth, and ninth grade adolescents (N = 66,859). Routine activities were operationalized as family, peer, solitary, and community activities. Country-level predictors included unemployment rate, prison population, life expectancy, and educational attainment. Results Three-level, hierarchical linear modeling (individual, school, and country) was used to test both individual and country-level effects on deviance. Findings supported predictions by the routine activities framework, where routine activities explained 3.1% unique variance in deviance, above and beyond effects by background variables as well as low self-control. Models showed that the effects of family activities, solitary activities, and peer activities were stronger in countries with higher life expectancies. In addition, mean educational attainment increased the effect of solitary activities on deviance, while the effect of family activities on deviance was lower in countries with higher levels of unemployment. Conclusions The routine activities framework generalized across these 28 countries in how it explains deviance; some unique country-level effects were found that conditioned person-context links

Vascular Smooth Muscle-Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson-Gilford Progeria Syndrome

Background: Progerin, an aberrant protein that accumulates with age, causes the rare genetic disease Hutchinson-Gilford progeria syndrome (HGPS). Patients who have HGPS exhibit ubiquitous progerin expression, accelerated aging and atherosclerosis, and die in their early teens, mainly of myocardial infarction or stroke. The mechanisms underlying progerin-induced atherosclerosis remain unexplored, in part, because of the lack of appropriate animal models. Methods: We generated an atherosclerosis-prone model of HGPS by crossing apolipoprotein E-deficient (Apoe(-/-)) mice with Lmna(G609G/G609G) mice ubiquitously expressing progerin. To induce progerin expression specifically in macrophages or vascular smooth muscle cells (VSMCs), we crossed Apoe(-/-)Lmna(LCS/LCS) mice with LysMCre and SM22Cre mice, respectively. Progerin expression was evaluated by polymerase chain reaction and immunofluorescence. Cardiovascular alterations were determined by immunofluorescence and histology in male mice fed normal chow or a high-fat diet. In vivo low-density lipoprotein retention was assessed by intravenous injection of fluorescently labeled human low-density lipoprotein. Cardiac electric defects were evaluated by electrocardiography. Results:Apoe(-/-)Lmna(G609G/G609G) mice with ubiquitous progerin expression exhibited a premature aging phenotype that included failure to thrive and shortened survival. In addition, high-fat diet-fed Apoe(-/-)Lmna(G609G/G609G) mice developed a severe vascular pathology, including medial VSMC loss and lipid retention, adventitial fibrosis, and accelerated atherosclerosis, thus resembling most aspects of cardiovascular disease observed in patients with HGPS. The same vascular alterations were also observed in Apoe(-/-)Lmna(LCS/LCS)SM22Cre mice expressing progerin specifically in VSMCs, but not in Apoe(-/-)Lmna(LCS/LCS)LysMCre mice with macrophage-specific progerin expression. Moreover, Apoe(-/-)Lmna(LCS/LCS)SM22Cre mice had a shortened lifespan despite the lack of any overt aging phenotype. Aortas of ubiquitously and VSMC-specific progerin-expressing mice exhibited increased retention of fluorescently labeled human low-density lipoprotein, and atheromata in both models showed vulnerable plaque features. Immunohistopathological examination indicated that Apoe(-/-)Lmna(LCS/LCS)SM22Cre mice, unlike Apoe(-/-)Lmna(G609G/G609G) mice, die of atherosclerosis-related causes. Conclusions: We have generated the first mouse model of progerin-induced atherosclerosis acceleration, and demonstrate that restricting progerin expression to VSMCs is sufficient to accelerate atherosclerosis, trigger plaque vulnerability, and reduce lifespan. Our results identify progerin-induced VSMC death as a major factor triggering atherosclerosis and premature death in HGPS.Work in Dr Andres' laboratory is supported by grants from the Spanish Ministerio de Economia, Industria y Competitividad (MEIC) (SAF2016-79490-R) and the Instituto de Salud Carlos III (AC16/00091, AC17/00067) with co-funding from the Fondo Europeo de Desarrollo Regional (FEDER, ``Una manera de hacer Europa´´), the Progeria Research Foundation (Established Investigator Award 2014-52), and the Fundacio Marato TV3 (122/C/2015). The MEIC supported Dr Hamczyk (´´Formacion de Personal Investigador´´ predoctoral contract BES-2011-043938) and Dr Villa-Bellosta (´´Juan de la Cierva´´ JCI-2011-09663 postdoctoral contract). The Instituto Universitario de Oncologia is supported by Obra Social Cajastur. The Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) is supported by the MEIC and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (award SEV-2015-0505).S